Focal epilepsy

This trial is testing whether an experimental medication called PRAX-628 can reduce the frequency of focal seizures in adults with epilepsy who are already taking one to three other seizure medications. Participants will receive either PRAX-628 or a placebo for 12 weeks, with the…

This study tests a non-invasive brain stimulation technique called slow-oscillatory transcranial direct current stimulation (so-tDCS) in people with focal epilepsy that doesn't respond to medication. Ten participants received 14 days of twice-daily sessions, with the stimulation …

This study tested a drug called cenobamate in 519 adults with partial onset seizures (focal seizures). Participants took cenobamate or a placebo alongside their usual seizure medications. The goal was to see if cenobamate could safely reduce seizure frequency. Results showed a si…

This Phase 3 trial tested a drug called XEN1101 (azetukalner) in 380 adults with focal-onset seizures that were not well-controlled by other medications. Participants took either XEN1101 or a placebo alongside their usual seizure drugs. The study measured whether XEN1101 reduced …

This pilot study tested a non-invasive brain stimulation technique called tDCS in 17 people with drug-resistant epilepsy. The stimulation was personalized using prior brain recordings to target the exact area causing seizures. The goal was to see if this approach could safely red…

This study looked at the long-term safety of brivaracetam, a drug added to existing epilepsy treatments for people with uncontrolled focal seizures. 141 Chinese adults who completed a prior trial took brivaracetam for up to a year or more. Researchers tracked side effects and sei…

This study tested an investigational drug called RAP-219 in 30 adults with refractory focal epilepsy—seizures that don't respond well to current treatments. Participants took RAP-219 tablets to see if it safely reduces seizure frequency. The trial is now complete, and results wil…

This study looked at the long-term safety of brivaracetam, a seizure medication, when added to existing treatment in 257 children with epilepsy. The main goal was to track side effects over time. Researchers also measured how well the drug controlled seizures. The results help do…

This Phase 3 trial tested whether adding brivaracetam (Briviact) to existing epilepsy medications could safely reduce partial seizures in adults aged 16 to 80. About 449 participants who still had frequent seizures despite taking 1 or 2 other drugs were randomly assigned to recei…

This study tested whether a single dose of naloxone, given right after a generalized tonic-clonic seizure, can help people with epilepsy breathe better and avoid sudden death. Researchers enrolled 485 adults with drug-resistant epilepsy who were already in the hospital for monito…

This study tested whether a special type of MRI that measures sodium levels in the brain can help locate the exact area causing seizures in people with drug-resistant epilepsy. 78 patients who were already scheduled for epilepsy surgery received a sodium MRI scan. Researchers com…

This study looked at using a heat-based technique called thermocoagulation in 100 children aged 1.5 to 17 years with focal epilepsy that doesn't respond to medication. During a brain monitoring procedure, doctors applied small heat lesions to the area where seizures start, aiming…

This study tested a device that sends a very mild electrical current to the brain (tDCS) to see if it can safely reduce seizures in people with epilepsy that doesn't respond to medication. 127 participants aged 9 and older received either real or fake (sham) stimulation for 10 se…

This study looked at brain activity in 37 children with epilepsy using two devices: EEG (which records electrical brain signals) and NIRS (which measures blood oxygen levels in the brain). The goal was to better understand what happens in the brain during seizures and between sei…

This study looked at how weak electric currents applied to the scalp can change brain activity in people with drug-resistant focal epilepsy. Researchers used special brain recordings to measure spikes and connections between brain regions during and right after stimulation. The g…

This study tested whether special microelectrodes can record 'fast ripples'—tiny brain signals that may help locate where seizures start. 54 adults with drug-resistant epilepsy who needed brain monitoring for surgery planning took part. The goal was to see if these electrodes cou…

This study tested a new type of brain sensor that is cheaper and easier to use than current ones. Researchers compared it to standard sensors in 4 people with epilepsy to see if it could detect abnormal brain activity. The goal is to make advanced brain imaging more widely availa…

This study tested a medicine called cenobamate in 26 children with partial-onset seizures. The goal was to see how the drug moves through the body and if it is safe. The study did not aim to cure or control seizures long-term, but to gather important information for future use.

This completed study enrolled over 1,000 people with drug-resistant partial epilepsy to see if severe drops in oxygen levels during seizures can predict later sudden unexpected death (SUDEP). Participants had their seizures recorded with video-EEG monitoring. The goal is to bette…

This study looked at whether combining EEG and fMRI scans can better pinpoint the exact brain area causing seizures in people with drug-resistant focal epilepsy. 102 participants who were already being evaluated for surgery had this extra scan. The goal was to see if the combined…

This study looked at whether tiny molecules in the blood, called microRNAs, can identify epilepsy patients who have dangerous drops in oxygen during seizures. Researchers compared 50 drug-resistant epilepsy patients undergoing video-EEG monitoring, splitting them into those who h…

This study involved 47 people with drug-resistant epilepsy and healthy volunteers. Researchers recorded brain activity simultaneously using implanted electrodes (intracranial EEG) and non-invasive scans (MEG or fMRI). The goal was to better identify seizure-causing brain areas an…