Familial avascular necrosis of femoral head
MONDO:0012126Avascular necrosis of femoral head (ANFH) is a severely disabling disease characterized by progressive groin pain, a limping gait, leg length discrepancy, collapse of the subchondral bone, limitation of hip function and eventual degeneration of the hip joint requiring total hip arthroplasty.
Also known as: aseptic Necrosis of femoral head, aseptic Necrosis of head of femur, familial osteonecrosis of the femoral head, ANFH, ANFH1, avascular NECROSIS of femoral head, primary, avascular NECROSIS of femoral head, primary, 1, avascular Necrosis of femoral head, primary, 1
70 clinical trials for this condition and its sub-types.
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Broader categories
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New hip implant aims to cut repeat surgeries
Disease control OngoingThis study is testing a new hip implant called the OR3O Dual Mobility System in 177 people who need hip replacement surgery. The goal is to see if the implant is safe and lasts longer without needing another surgery. Researchers will follow participants for up to 10 years to chec…
Sponsor: Smith & Nephew, Inc. • Aim: Disease control
Last updated Jul 04, 2026 00:00 UTC
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Hip replacement device study pulled before it started
Disease control TerminatedThis study planned to test a new hip replacement device (the HYPE stem) in people with hip arthritis or other hip damage. The goal was to see how well the device works and if it is safe. However, the study was withdrawn before any participants were enrolled, so no results are ava…
Sponsor: Societe dEtude, de Recherche et de Fabrication • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Can stem cells save dying hip bones? new study halted
Disease control TerminatedThis study tests a treatment using stem cells from donated umbilical cords for people with early-stage osteonecrosis (bone death) of the hip. The goal is to see if the cells are safe and can help control the disease, possibly avoiding the need for hip replacement. The study was s…
Phase: PHASE1, PHASE2 • Sponsor: Sclnow Biotechnology Co., Ltd. • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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New combo treatment aims to save hips from collapse
Disease control OngoingThis study tests a procedure for people with early-stage osteonecrosis (bone death) of the hip. Doctors drill into the hip bone, inject a concentrated sample of the patient's own bone marrow, and add a special bone graft material called Genex. The goal is to see if this helps bon…
Sponsor: The Cleveland Clinic • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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New drug aims to stop hip bone death from steroids
Disease control OngoingThis study tests a new drug called RAB001 in people with early-stage hip bone damage caused by long-term steroid use. About 160 participants will receive either a low, medium, or high dose of RAB001, or a standard bone drug (alendronate). The goal is to see if RAB001 can reduce t…
Phase: PHASE2 • Sponsor: ZhongShan LaiBo RuiChen BioMedicine Co.,Ltd. • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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Hip replacement stem under review: 5-Year safety and performance study
Disease control OngoingThis study looks at the safety and performance of a cemented hip stem (TrendHip®) in 119 people who had hip replacement surgery. It tracks pain, function, and quality of life for up to 5 years after surgery. The goal is to confirm the device works well in everyday use.
Phase: NA • Sponsor: Aesculap AG • Aim: Disease control
Last updated Jun 27, 2026 09:07 UTC
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Hip implant under the microscope: 2-Year safety check
Disease control OngoingThis study follows 102 people who received the aneXys hip replacement cup to see how safe and effective it is over 2 years. Researchers measure if the cup moves and track pain and function using standard scores. The goal is to confirm the device works well in everyday use.
Sponsor: Mathys Ltd Bettlach • Aim: Disease control
Last updated Jun 27, 2026 09:02 UTC
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New hip implant coating aims to cut infection risk and boost bone bonding
Disease control OngoingThis study tests a new coating on a hip replacement implant that may help prevent infections and help the implant bond better with the bone. About 340 adults needing a hip replacement will receive either the coated or standard implant. The goal is to see if the coated implant wor…
Phase: NA • Sponsor: Societe ACTIVBIOMAT • Aim: Disease control
Last updated Jun 27, 2026 08:06 UTC
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Hip implant Follow-Up study aims to confirm Long-Term safety
Disease control OngoingThis study tracks 100 adults who need a hip replacement to see how well the Avenir cemented hip stem works and holds up over time. Participants have conditions like arthritis, hip fractures, or hip damage from past surgeries. The main goal is to measure how long the implant lasts…
Sponsor: Zimmer Biomet • Aim: Disease control
Last updated Jun 27, 2026 07:59 UTC
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New hip stem tested for Long-Term stability
Disease control OngoingThis study is tracking 100 people who received a total hip replacement with a specific implant called AMIStem C. The main goal is to see how much the implant moves inside the bone over time, using special X-ray analysis. Researchers will also check how well patients recover and h…
Sponsor: Medacta International SA • Aim: Disease control
Last updated Jun 27, 2026 07:52 UTC
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New hip implant tracked for 10 years – will it last?
Disease control OngoingThis study follows 300 adults aged 18-75 who received a specific type of hip implant (Quadra-P stem) during hip replacement surgery. The goal is to see how well the implant works over 10 years, including how long it lasts and how it improves pain and movement. Participants have c…
Sponsor: Medacta International SA • Aim: Disease control
Last updated Jun 27, 2026 07:52 UTC
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New combo nerve block may ease hip surgery pain better
Symptom relief ENROLLING_BY_INVITATIONThis study tests if adding two extra nerve blocks to a standard one can improve pain control and recovery after hip replacement surgery. About 60 adults having hip surgery will be randomly assigned to receive either the standard block alone or the standard block plus the extra bl…
Phase: NA • Sponsor: Ataturk University • Aim: Symptom relief
Last updated Jun 27, 2026 08:02 UTC
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Weekly Check-Ins could boost patient satisfaction for chronic pain
Knowledge-focused TerminatedThis study looked at whether having more frequent contact with a clinician (at least once a week) improves satisfaction for people with long-lasting musculoskeletal conditions. Participants were split into two groups: one with standard contact and one with extra check-ins via tex…
Phase: NA • Sponsor: University of Texas at Austin • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:06 UTC
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Massive hip replacement study seeks best stem length
Knowledge-focused ENROLLING_BY_INVITATIONThis study looks at over 110,000 people who had hip replacement surgery to see if a longer or shorter hip stem works better. It compares death rates, how often the hip implant needs to be replaced, and patient-reported pain and function. The goal is to find out which stem length …
Sponsor: JointResearch • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:32 UTC
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Can a special clinic get workers back on the job faster? norway launches massive study.
Knowledge-focused OngoingThis study tests whether a Norwegian clinic (NSAC) helps people with common mental health issues or muscle pain return to work sooner. 2500 adults are split into three groups: one gets treatment quickly, one waits 10-14 weeks, and one gets a basic check-up. Researchers will track…
Phase: NA • Sponsor: Nordlandssykehuset HF • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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New hip cup under observation: will it last?
Knowledge-focused OngoingThis study is observing 60 people who received a special hip replacement cup (Plasmafit Revision Structan) during routine surgery. Researchers are checking how well the cup works and how long it lasts by tracking hip function and any need for repeat surgery. No new treatment is b…
Sponsor: Aesculap AG • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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500 patients revisited: how do childhood hip surgeries hold up decades later?
Knowledge-focused OngoingThis study looks at how well treatments for childhood hip conditions (like hip dysplasia and Perthes disease) work over the long term. Researchers at Mayo Clinic are following 500 adults who were treated for these conditions as children. They will check how many needed another su…
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:03 UTC
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New hip implant under observation: will it stand the test of time?
Knowledge-focused OngoingThis study follows 248 adults receiving a CoreHip hip replacement to see how their hip function, pain, and leg length change over time. Participants are treated as part of routine care, and no extra tests or treatments are given. The goal is to collect real-world data on the impl…
Sponsor: Aesculap AG • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:02 UTC
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Massive PT study mines 4 million records to find what works best
Knowledge-focused OngoingThis study looks back at the medical records of about 4 million people who had physical or occupational therapy for muscle and joint problems. Researchers want to see if different ways of giving therapy lead to different results. No new treatments are tested—the goal is to learn …
Sponsor: ATI Holdings, LLC • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:11 UTC
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Phone app vs. doctor: can a mobile tool catch infections after surgery?
Knowledge-focused TerminatedThis study aimed to see if a mobile monitoring tool could accurately identify surgical site infections (SSIs) in orthopedic surgery patients, compared to the usual manual review. The study was withdrawn before enrolling any participants, so no results are available. It was design…
Phase: NA • Sponsor: Stanford University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC