Familial avascular necrosis of femoral head
MONDO:0012126Avascular necrosis of femoral head (ANFH) is a severely disabling disease characterized by progressive groin pain, a limping gait, leg length discrepancy, collapse of the subchondral bone, limitation of hip function and eventual degeneration of the hip joint requiring total hip arthroplasty.
Also known as: aseptic Necrosis of femoral head, aseptic Necrosis of head of femur, familial osteonecrosis of the femoral head, ANFH, ANFH1, avascular NECROSIS of femoral head, primary, avascular NECROSIS of femoral head, primary, 1, avascular Necrosis of femoral head, primary, 1
38 clinical trials for this condition and its sub-types.
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Stem cells and oxygen therapy may save hips from collapse
Disease control CompletedThis study tested a triple therapy—surgery, stem cells, and hyperbaric oxygen—in 24 patients with early-stage osteonecrosis (bone death) of the hip. After two years, patients reported better hip function and fewer needed a hip replacement. The approach aims to stop the bone from …
Sponsor: Ankara City Hospital Bilkent • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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Bone filler injection in hip shows promise for pain relief
Disease control CompletedThis study followed 77 people who had a procedure called Subchondroplasty for hip bone defects. Doctors injected a calcium phosphate bone filler into the damaged area. The goal was to see if it improved pain, movement, and daily activities over two years. Results were measured us…
Sponsor: Zimmer Biomet • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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New drug RAB001 takes first step: safety check in healthy volunteers
Knowledge-focused CompletedThis early-stage study tested the safety and tolerability of a new drug called RAB001 in 16 healthy adults. Researchers gave single and multiple injections at two dose levels to see how the body handles the drug and if it causes side effects. This is a first step before testing t…
Phase: PHASE1 • Sponsor: ZhongShan LaiBo RuiChen BioMedicine Co.,Ltd. • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Scientists examine bone tissue to uncover causes of hip joint decay
Knowledge-focused CompletedThis study looked at bone tissue from 34 men who had hip replacement surgery due to femoral head necrosis (bone death in the hip joint). Researchers used advanced imaging and spectroscopy to identify changes in bone structure and composition. The goal was to better understand wha…
Phase: NA • Sponsor: Lille Catholic University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:10 UTC