Eye infectious disorder

This study tests whether a light-activated dye called rose Bengal, combined with antibiotics and steroids, can improve vision in people with severe bacterial eye infections. About 60 adults with corneal ulcers and vision loss will receive either the dye treatment or a sham proced…

This study offers kidney transplant patients with antibody-mediated rejection (AMR) the chance to receive felzartamab for up to 4 more years. AMR occurs when the immune system attacks the new kidney. The main goal is to check long-term safety and monitor kidney health through bio…

This trial tests whether implanting a thin disc of donor cornea tissue — called a stromal lenticule — can improve corneal transparency and vision in people with herpetic stromal keratitis, a herpes infection that scars the cornea. The lenticule contains stem cells and other livin…

This trial tests a two-part approach for people with corneal scarring caused by adenoviral keratitis. Surgeons first remove the scarred tissue using a laser technique called SMILE, then implant a fresh, clear corneal lenticule of the same size into the pocket. Patients also recei…

This study tests four different drug combinations in 300 adults with onchocerciasis (river blindness), a parasitic disease. Participants first receive ivermectin to clear skin and eye parasites, then get one of the new combos. The goal is to see which combo is safest and most eff…

This study aimed to see if a soft membrane placed on the eye could diagnose microbial keratitis (a serious eye infection) better and more comfortably than the standard scrape test. Researchers planned to compare the two methods in adults with new corneal infections. However, the …

This study tests whether analyzing fluid from the eye can predict which immunosuppressive drug will work best for people with non-infectious uveitis, an eye inflammation condition. About 220 participants who haven't responded well to steroids will provide eye fluid and blood samp…

This study reviews medical records of 200 people in Singapore with inflammatory eye diseases like uveitis and scleritis. Researchers want to understand who gets these conditions, what treatments they receive, and how they do over time. No new treatments are being tested—this is p…

This study follows 2,500 people who visit freshwater beaches in Ontario, Manitoba, and Nova Scotia to see if contact with water containing blue-green algae (cyanobacteria) leads to stomach bugs, respiratory issues, or skin/eye infections. Researchers will also track illness in pe…