Esophageal varices with bleeding

This study looks at whether adding L-carnitine, a natural substance, to standard care can improve outcomes for critically ill adults with liver disease in the ICU. About 58 participants with conditions like liver failure or severe infections will be enrolled. Researchers will tra…

This study compares two ways of placing a stent in the liver to prevent repeat bleeding from swollen veins in the throat or stomach in people with cirrhosis. The standard method fully expands the stent, while the new method uses a smaller balloon to keep it slightly narrower. The…

This study tests a newer, ultrasound-guided endoscopic technique to prevent repeat bleeding from enlarged veins in the stomach or esophagus of liver cancer patients. About 84 adults who recently had such bleeding controlled by standard endoscopy will be randomly assigned to recei…

This study tests whether a Botox injection into the stomach valve works as well as a surgical cut to prevent food from emptying too slowly after esophagus removal. About 170 adults having elective esophagectomy will be randomly assigned to one of the two procedures. Researchers w…

This study looks at a two-part procedure to prevent repeat bleeding in people with cavernous transformation of the portal vein, a rare condition where the main vein to the liver is blocked. The procedure involves blocking the bleeding veins and partially blocking the splenic arte…

This study tests a special stent called LIVERTY TIPS, placed in the liver to create a new pathway for blood flow in people with cirrhosis and high blood pressure in the liver. The goal is to see if it can keep the new channel open and reduce problems like bleeding or fluid buildu…

This study tests a new MRI contrast agent called ferumoxytol, made from iron nanoparticles, to see if it can safely and effectively image veins in people with vein diseases. Current dyes can be risky for patients with kidney problems, but ferumoxytol may be safer and last longer …

This study tests a magnetically controlled capsule endoscope—a tiny camera you swallow—to painlessly screen the esophagus and stomach. Researchers will compare different swallowing protocols to see which gives the best view of the Z-line and other areas. 300 patients already sche…

This trial asks whether single-use gastroscopes work as well as standard reusable ones for elective and subacute upper GI procedures. About 300 adults will be examined with either a disposable or a reusable scope, and endoscopists will rate performance on a questionnaire. The stu…

This study compares two techniques—esophageal manometry and EndoFLIP balloon measurements—to evaluate how well they assess swallowing difficulties (dysphagia). Researchers will enroll up to 1,000 patients with known esophageal conditions to see how these measurements relate to sy…

This study looks at whether giving proton pump inhibitors (like omeprazole) to people with cirrhosis who have bleeding in the esophagus causes more complications in the hospital. Researchers will randomly assign 60 adults to receive either the drug or no drug after an endoscopic …

This study is creating a large collection of medical data and biological samples from 1000 people with portal hypertension, a condition that can cause dangerous bleeding in the esophagus or stomach. The goal is to use advanced technologies like genetics and imaging to better unde…

This study follows 10,000 people with advanced chronic liver disease at Vienna General Hospital. Researchers will track their health over time, collect blood, urine, and tissue samples, and record complications like bleeding or liver failure. The goal is to better understand how …