Epilepsy
MONDO:0005027A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.
Also known as: epilepsy, seizure disorder
645 clinical trials for this condition and its sub-types, 461 tagged with Epilepsy itself.
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Sub-types of Epilepsy
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Epilepsy syndrome 2 trials · 181 incl. sub-types
8 sub-types
- Childhood-onset epilepsy syndrome 18 trials · 106 incl. sub-types Sub-types →
- Neonatal/infantile epilepsy syndrome 1 trial · 55 incl. sub-types Sub-types →
- Variable age epilepsy syndrome 0 trials · 31 incl. sub-types Sub-types →
- Myoclonic epilepsy 1 trial · 16 incl. sub-types Sub-types →
- Infantile epilepsy syndrome 2 trials · 10 incl. sub-types Sub-types →
- Neonatal epilepsy syndrome 1 trial · 7 incl. sub-types Sub-types →
- Adolescence-adult electroclinical syndrome 0 trials
- Benign focal seizures of adolescence 0 trials
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Reflex epilepsy 1 trial · 155 incl. sub-types
10 sub-types
- Visual epilepsy 152 trials Sub-types →
- Inherited reflex epilepsy 0 trials · 3 incl. sub-types Sub-types →
- Audiogenic seizures 0 trials
- Eating seizures 0 trials
- Micturation-induced seizures 0 trials
- Orgasm-induced seizures 0 trials
- Reading seizures 0 trials
- Startle epilepsy 0 trials
- Tactile epilepsy 0 trials
- Thinking seizures 0 trials
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Focal epilepsy 101 trials · 135 incl. sub-types
9 sub-types
- Familial partial epilepsy 0 trials · 39 incl. sub-types Sub-types →
- Frontal lobe epilepsy 5 trials Sub-types →
- Childhood-onset self-limited focal epilepsy syndrome 0 trials · 3 incl. sub-types Sub-types →
- Partial motor epilepsy 1 trial
- Combined generalized and focal epilepsy 0 trials Sub-types →
- Complex partial epilepsy 0 trials
- Partial sensory epilepsy 0 trials
- Simple partial epilepsy 0 trials
- Variable-age onset focal epilepsy syndrome 0 trials Sub-types →
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Developmental and epileptic encephalopathy 29 trials · 98 incl. sub-types
3 sub-types
- Genetic developmental and epileptic encephalopathy 2 trials · 83 incl. sub-types Sub-types →
- Early-infantile DEE 2 trials Sub-types →
- Acquired developmental and epileptic encephalopathy 0 trials
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Generalized epilepsy 9 trials · 39 incl. sub-types
2 sub-types
- Genetic generalized epilepsy 2 trials · 34 incl. sub-types Sub-types →
- Combined generalized and focal epilepsy 0 trials Sub-types →
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Monogenic epilepsy 0 trials · 12 incl. sub-types
18 sub-types
- Developmental and epileptic encephalopathy, 2 10 trials
- Mowat-Wilson syndrome 2 trials Sub-types →
- Neuronal ceroid lipofuscinosis 8 northern epilepsy variant 1 trial
- X-linked intellectual disability-epilepsy syndrome 0 trials Sub-types →
- Autosomal recessive cerebellar ataxia - epilepsy - intellectual disability syndrome 0 trials Sub-types →
- Developmental and epileptic encephalopathy, 23 0 trials
- Developmental and epileptic encephalopathy, 73 0 trials
- Epilepsy, X-linked, with or without impaired intellectual development and dysmorphic features 0 trials Sub-types →
- Familial infantile myoclonic epilepsy 0 trials
- Focal epilepsy-intellectual disability-cerebro-cerebellar malformation 0 trials
- Infantile-onset mesial temporal lobe epilepsy with severe cognitive regression 0 trials
- Intellectual developmental disorder with dysmorphic facies, seizures, and distal limb anomalies 0 trials
- Neonatal-onset encephalopathy with rigidity and seizures 0 trials
- Neurodevelopmental disorder with epilepsy, cataracts, feeding difficulties, and delayed brain myelination 0 trials
- Neurodevelopmental disorder with motor abnormalities, seizures, and facial dysmorphism 0 trials
- Polyhydramnios, megalencephaly, and symptomatic epilepsy 0 trials
- Severe neonatal-onset encephalopathy with microcephaly 0 trials
- Spastic paraplegia-severe developmental delay-epilepsy syndrome 0 trials
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Metabolic epilepsy 0 trials · 8 incl. sub-types
4 sub-types
- GLUT1 deficiency syndrome 4 trials · 5 incl. sub-types Sub-types →
- Pyridoxine-dependent epilepsy 3 trials Sub-types →
- Pyridoxal phosphate-responsive seizures 2 trials
- Folinic acid-responsive seizures 0 trials
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Post-traumatic epilepsy 6 trials
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Structural epilepsy 5 trials
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Infantile-onset epilepsy 1 trial
2 sub-types
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Immune epilepsy 0 trials · 1 incl. sub-types
2 sub-types
- Autoimmune epilepsy 1 trial
- Antibody mediated epilepsy 0 trials
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Extratemporal epilepsy 0 trials
Most studied deeper sub-types
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Can stem cells boost brain surgery for epilepsy?
Disease control Stopped earlyThis early study tests whether delivering stem cells directly into the brain during deep brain stimulation (DBS) surgery is safe and feasible for people with drug-resistant epilepsy. One adult participant will receive a single dose of stem cells in the thalamus, a brain region in…
Early phase 1 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Sep 10, 2026 00:00 UTC
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New drug shows promise for Tough-to-Treat seizures in kids
Disease control Stopped earlyThis study looked at the long-term safety of soticlestat, an experimental drug, in children and adults with severe forms of epilepsy like Dravet syndrome and Lennox-Gastaut syndrome. Participants took soticlestat twice a day along with their usual seizure medicines. The study was…
Phase 2 • Sponsor: Takeda • Aim: Disease control
Last updated Sep 06, 2026 00:00 UTC
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Promising seizure drug study halted early
Disease control Stopped earlyThis study looked at the long-term safety of the drug NBI-921352 for people with a rare genetic seizure disorder called SCN8A-DEE. It was an extension of an earlier study, and participants took the drug alongside their usual seizure medications. The study was stopped early and on…
Phase 2 • Sponsor: Neurocrine Biosciences • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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Brain implant study aims to cut seizures in epilepsy patients
Disease control Stopped earlyThis study tested a brain implant (deep brain stimulation) to reduce seizures in 29 adults with epilepsy whose seizures were not controlled by medication. Participants kept diaries to track seizure frequency over three years. The goal was to see if the device safely and effective…
Sponsor: MedtronicNeuro • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Epilepsy drug study halted early: BHV-7000 shows limited promise
Disease control Stopped earlyThis study tested whether BHV-7000, taken alongside other medications, could reduce generalized tonic-clonic seizures in people with idiopathic generalized epilepsy. The trial was terminated early and enrolled only 27 adults aged 18-75. The main goal was to see how long it took f…
Phase 2/3 • Sponsor: Biohaven Therapeutics Ltd. • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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Epilepsy drug study for kids halted early: what we know
Disease control Stopped earlyThis study looked at the long-term safety of a drug called NBI-827104 in children with a rare epilepsy that causes seizures during sleep. The trial was stopped early and only enrolled 19 children, so the results are limited. The main goal was to see how many children had serious …
Phase 2 • Sponsor: Neurocrine Biosciences • Aim: Disease control
Last updated Jun 27, 2026 09:05 UTC
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Seizure drug study ends early – safety results awaited
Disease control Stopped earlyThis study looked at the long-term safety of an experimental drug called CVL-865 in adults whose focal seizures were not controlled by other medications. About 105 people who completed a previous trial took CVL-865 alongside their usual seizure drugs for up to 57 weeks. The study…
Phase 2 • Sponsor: AbbVie • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC
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Promising epilepsy drug trial halted early – what we know
Disease control Stopped earlyThis study tested an experimental drug called NBI-921352 in people aged 2 to 21 with a rare, severe form of epilepsy caused by a change in the SCN8A gene. The goal was to see if adding this drug to their current seizure medicines could reduce how often they had seizures. The tria…
Phase 2 • Sponsor: Neurocrine Biosciences • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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Seizure drug study halted after just one patient
Disease control Stopped earlyThis study tested the drug perampanel in adults whose seizures did not stop with standard treatments. The goal was to see if it could safely stop seizures and reduce time in the hospital. Only one person enrolled before the study was ended early, so no clear conclusions can be dr…
Phase 4 • Sponsor: Wayne State University • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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Dravet syndrome drug trial halted early: did lorcaserin help?
Disease control Stopped earlyThis study tested whether lorcaserin, when added to current medications, could reduce convulsive seizures in people with Dravet syndrome, a severe form of epilepsy. The trial planned to enroll about 22 participants aged 2 and older, but it was terminated early. The main goal was …
Phase 3 • Sponsor: Eisai Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:53 UTC
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New drug tested for newborn seizures – but trial halted early
Disease control Stopped earlyThis study tested the drug lacosamide in newborns with repeated seizures that were not controlled by standard medicines. The trial was small (29 babies) and was stopped early. Researchers compared lacosamide to usual care to see if it could reduce seizure time on brain monitoring…
Phase 2 • Sponsor: UCB Biopharma SRL • Aim: Disease control
Last updated Jun 27, 2026 07:53 UTC
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Brain tumor drug trial fizzles: only 3 patients enrolled
Symptom relief Stopped earlyThis early-phase trial tested whether brivaracetam, a seizure medication, is safe for people with diffuse gliomas (a type of brain tumor). Only 3 participants were enrolled before the study was terminated. The main goal was to track side effects, not to measure tumor shrinkage or…
Early phase 1 • Sponsor: University of Rochester • Aim: Symptom relief
Last updated Jun 27, 2026 13:00 UTC
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Cooling the brain through the nose: new device tested for ICU fever
Symptom relief Stopped earlyThis study tested a device called CoolStat that is placed in the nose to cool down brain-injured patients with fever in the ICU. The goal was to see if it could safely and quickly bring their temperature to normal. Only 9 patients were enrolled before the study was stopped early,…
Sponsor: CoolTech LLC • Aim: Symptom relief
Last updated Jun 27, 2026 08:14 UTC
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CBD study for baby seizures halted early
Symptom relief Stopped earlyThis study tested a cannabidiol (CBD) oral solution in children under 2 years old with tuberous sclerosis complex, Dravet syndrome, or Lennox-Gastaut syndrome who had uncontrolled seizures. The goal was to see if CBD is safe and can reduce seizures. However, the study was termina…
Phase 3 • Sponsor: Jazz Pharmaceuticals • Aim: Symptom relief
Last updated Jun 27, 2026 07:56 UTC
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UK study tracks Real-World impact of nerve stimulation on epilepsy
Knowledge-focused Stopped earlyThis study followed 97 people with drug-resistant epilepsy in the UK who had a vagus nerve stimulation (VNS) device implanted. Researchers looked at medical records and patient surveys to see how the therapy affected hospital visits and seizures over time. The goal was to underst…
Sponsor: LivaNova • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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Blood protein may predict seizure return, study halted early
Knowledge-focused Stopped earlyThis study looked at whether measuring a protein called S100B in the blood right after a first seizure could help predict if someone will have more seizures within a year. The researchers planned to follow 37 adults for one year, but the study was stopped early. The goal was to f…
Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC
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New Dry-Electrode EEG lets epilepsy patients record brain waves at home
Knowledge-focused Stopped earlyThis study tested a new dry-electrode EEG headset that people with epilepsy can use at home to record their brain activity. Five adults with epilepsy first had a standard EEG in the clinic, then used the dry-electrode headset at home for 14 days. The goal was to see if the home r…
Sponsor: Karl Landsteiner Institute for Clinical Epilepsy Research and Cognitive Neurology • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:08 UTC
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Brain surgery scanner tested – but study halted early
Knowledge-focused Stopped earlyThis study tested a new 3D scanner to measure how the brain shifts during surgery for epilepsy or tumor removal. Only one person took part before the study was stopped. The goal was to see if the scanner could accurately track brain surface changes over time, which could help sur…
Sponsor: Advanced Scanners Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC
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New implant could track seizures for months
Knowledge-focused Stopped earlyThis study tested a small device implanted under the scalp to record brain waves (EEG) continuously for up to 12 weeks in people with epilepsy. The goal was to see if it could detect seizures better than standard short-term hospital monitoring and patient diaries. The trial invol…
Sponsor: UNEEG Medical A/S • Aim: Knowledge-focused
Last updated Jun 26, 2026 13:35 UTC