Enthesitis-related juvenile idiopathic arthritis
MONDO:0019437Enthesitis-related juvenile idiopathic arthritis is a subtype of juvenile idiopathic arthritis that is characterized by both arthritis and inflammation of an enthesitis site (the point at which a ligament, tendon, or joint capsule attaches to the bone). Signs and symptoms generally develop in late childhood or early adolescence and include pain, tenderness, and swelling in joints and at the enthesis. The knee and the back of the ankle (at the Achilles tendon) are the most commonly affected parts of the body. The underlying cause of enthesitis-related juvenile idiopathic arthritis is currently unknown (idiopathic). It is very rare for more than one member of a family to have juvenile arthritis; however, research suggests that having a family member with juvenile arthritis or any autoimmune disease may increase the risk of having juvenile arthritis, in general. Treatment usually involves different types of medications to help manage symptoms and/or physical therapy.
Also known as: ERA, enthesitis-related JIA, era, enthesitis related arthritis, juvenile, enthesitis-related arthritis, juvenile enthesitis-related arthritis, juvenile spondylarthropathy
31 clinical trials for this condition and its sub-types.
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New hope for kids with arthritis: drug trial shows promise
Disease control OngoingThis study tests whether the drug ixekizumab is safe and effective for children with certain types of juvenile arthritis (enthesitis-related arthritis and juvenile psoriatic arthritis). About 101 children aged 2 to 17 years will receive either ixekizumab or the standard drug adal…
Phase: PHASE3 • Sponsor: Eli Lilly and Company • Aim: Disease control
Last updated Aug 14, 2026 00:00 UTC
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Can a cheaper plastic knee implant match the metal one in older adults?
Disease control TerminatedThis trial compares two types of knee replacement implants in people aged 75 and older: a standard metal-backed component and a cheaper all-polyethylene (plastic) one. The goal is to see if the all-polyethylene implant performs as well in terms of pain relief, movement, and how l…
Phase: NA • Sponsor: Maidstone & Tunbridge Wells NHS Trust • Aim: Disease control
Last updated Jul 31, 2026 00:00 UTC
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New knee implant under watch: will it last?
Disease control OngoingThis study follows 200 people who receive a cementless knee replacement (GMK Sphere) to see how long the implant lasts and how well it works. Participants have severe knee damage from arthritis or other conditions. The goal is to monitor safety and performance in real-world use, …
Sponsor: Medacta International SA • Aim: Disease control
Last updated Jun 27, 2026 07:52 UTC
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New MRI technique aims to sharpen arthritis bone erosion detection
Diagnosis OngoingThis Mayo Clinic study tests a new 3D MRI sequence called oZTEo, enhanced with deep learning, to detect bone erosions in the hands of people with inflammatory arthritis. The goal is to see if this advanced scan finds erosions better than standard MRI or X-rays. The study will enr…
Phase: NA • Sponsor: Mayo Clinic • Aim: Diagnosis
Last updated Aug 16, 2026 00:00 UTC
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Can a biologic drug tame juvenile arthritis in kids?
Knowledge-focused TerminatedThis study follows children aged 6 to 17 with active juvenile enthesitis-related or psoriatic arthritis who are being treated with secukinumab. Researchers will track how long children stay on the drug, how much their symptoms improve, and whether they achieve remission. The goal…
Sponsor: Novartis Pharmaceuticals • Aim: Knowledge-focused
Last updated Aug 09, 2026 00:00 UTC
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Hip implant under the microscope: 5-Year safety study launched
Knowledge-focused OngoingThis study is tracking 120 people who received a HYPE SCS hip stem during total hip replacement. Researchers will monitor how long the implant lasts, how satisfied patients are, and any complications over 5 years. The goal is to confirm the device is safe and works as intended in…
Sponsor: Societe dEtude, de Recherche et de Fabrication • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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New study tests if help with housing, food, or transport can cut missed arthritis appointments
Knowledge-focused OngoingThis study looks at whether helping people with inflammatory arthritis address social needs—like food, housing, or transportation—can reduce missed doctor visits. About 100 adults with conditions like rheumatoid arthritis or lupus who have missed appointments in the past year wil…
Phase: NA • Sponsor: Brigham and Women's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC