Enthesitis-related juvenile idiopathic arthritis
MONDO:0019437Enthesitis-related juvenile idiopathic arthritis is a subtype of juvenile idiopathic arthritis that is characterized by both arthritis and inflammation of an enthesitis site (the point at which a ligament, tendon, or joint capsule attaches to the bone). Signs and symptoms generally develop in late childhood or early adolescence and include pain, tenderness, and swelling in joints and at the enthesis. The knee and the back of the ankle (at the Achilles tendon) are the most commonly affected parts of the body. The underlying cause of enthesitis-related juvenile idiopathic arthritis is currently unknown (idiopathic). It is very rare for more than one member of a family to have juvenile arthritis; however, research suggests that having a family member with juvenile arthritis or any autoimmune disease may increase the risk of having juvenile arthritis, in general. Treatment usually involves different types of medications to help manage symptoms and/or physical therapy.
Also known as: ERA, enthesitis-related JIA, era, enthesitis related arthritis, juvenile, enthesitis-related arthritis, juvenile enthesitis-related arthritis, juvenile spondylarthropathy
31 clinical trials for this condition and its sub-types.
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Could a simple pill boost knee replacement recovery?
Symptom relief Not yet recruitingThis study tests whether taking tranexamic acid pills for a week after knee replacement surgery helps people recover better. 350 adults having their first knee replacement will receive either the drug or a placebo. Researchers will track pain, stiffness, and function for up to 2 …
Phase: NA • Sponsor: NYU Langone Health • Aim: Symptom relief
Last updated Jun 27, 2026 12:00 UTC
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Can sound waves boost arthritis shots?
Symptom relief Not yet recruitingThis study tests whether using ultrasound therapy before a steroid injection into the joint can improve pain and swelling for people with arthritis. About 100 adults with arthritis in their arms or legs will receive the combined treatment. The goal is to see if the ultrasound hel…
Phase: NA • Sponsor: Taichung Veterans General Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 08:13 UTC
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New study eyes Tirzepatide's hidden impact on joints and heart
Knowledge-focused Not yet recruitingThis observational study in Mexico will follow 30 adults already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans of the knees, CT scans of the heart, and body composition tests to see how the drug affects cartilage, heart fat, and overal…
Sponsor: JULIO GRANADOS MONTIEL • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:31 UTC
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New study tracks how kids with arthritis fare on Long-Term secukinumab
Knowledge-focused Not yet recruitingThis study follows 100 children aged 6 to 17 with juvenile psoriatic or enthesitis-related arthritis who are taking secukinumab. Researchers will observe how doctors adjust treatment after the disease becomes inactive, and whether patients experience flares. The goal is to learn …
Sponsor: Novartis Pharmaceuticals • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC