Enterocolitis

This phase 2 study tests a drug called MAS825 in 17 people with rare genetic conditions that cause severe inflammation. The goal is to see if the drug can prevent disease flares better than a placebo. Participants will be monitored for safety and effectiveness over several period…

This study tests whether giving the steroid hydrocortisone early, right when shock is diagnosed, helps very small preterm babies (under 1500 grams) recover faster. Researchers will compare babies who get standard shock treatment plus hydrocortisone to those who get standard treat…

This study was designed to test whether a supplement called chondroitin sulfate is safe for newborns with necrotizing enterocolitis (NEC), a severe gut infection. The plan was to give the supplement to very low birth weight babies for two days and compare their outcomes to those …

This study tests whether giving probiotics to preterm babies (born before 35 weeks) can prevent necrotizing enterocolitis (NEC), a severe gut infection. About 196 infants will receive either probiotics or a placebo within 24 hours of birth. The main goal is to see if fewer babies…

This study looks for early signs of necrotizing enterocolitis (NEC), a severe gut infection in premature babies. Researchers will use non-invasive measures and blood markers to identify at-risk infants before symptoms start. The goal is to eventually prevent the disease from prog…

This study follows 300 premature babies born before 33 weeks to see if the bacteria in their stool can predict life-threatening conditions like necrotizing enterocolitis, a severe gut infection. Researchers will also analyze the babies' DNA from saliva and look at small molecules…

This study follows 200 premature babies who had a serious gut infection called necrotizing enterocolitis (NEC) to see how it affects their nutrition and growth by age 5. Researchers will check for problems like food allergies, poor growth, feeding difficulties, and other digestiv…

This study looks at a procedure called remote ischemic conditioning (RIC) for newborns with necrotizing enterocolitis (NEC), a serious gut disease. RIC involves briefly inflating a blood pressure cuff on the baby's arm to protect the gut from damage. The main goal is to see if a …

This research study aims to understand why some people develop food allergies and others outgrow them. Researchers at Children's Hospital of Philadelphia will collect blood samples from 5,300 people (ages 1 month to 65 years) with and without food allergies to study immune cells …