Endometrial endometrioid adenocarcinoma

This phase 3 trial tests whether adding targeted drugs (trastuzumab and pertuzumab) to standard chemotherapy can better shrink tumors in people with HER2-positive endometrial cancer. The study plans to enroll 360 participants with various stages of the disease. However, the trial…

This phase II trial is testing whether combining two immunotherapy drugs, nivolumab and ipilimumab, works better than nivolumab alone for women with recurrent endometrial cancer that has a specific DNA repair defect (dMMR). About 81 participants will receive either the combinatio…

This study tests whether a 24-week digital wellness platform, combined with one-on-one online sessions with a dietitian, exercise pro, and therapist, can help endometrial cancer survivors lose inches around their waist and improve their health. About 148 survivors who are overwei…

This study tests whether two drugs, abemaciclib and letrozole, can help keep advanced or recurrent endometrial cancer from getting worse. About 32 people with a specific type of estrogen-sensitive cancer will take these pills daily after initial treatment. The goal is to see if t…

Researchers are testing a combination of a gonadotropin-releasing hormone agonist injection and the drug letrozole in obese women with early-stage endometrial cancer that has not responded to progestin. The goal is to see if this hormone-blocking approach can shrink tumors and al…

Researchers test whether a combination of GnRHa and letrozole can shrink early endometrial cancer or atypical hyperplasia in non-obese patients who have not responded to progestin therapy. The trial compares this regimen with Diane-35 plus metformin. About 80 participants receive…

This early-phase trial is testing the safety and best dose of two drugs, M1774 and ZEN-3694, given together to patients with recurrent ovarian or endometrial cancer. The drugs work by blocking enzymes that cancer cells need to grow. The study aims to find a dose that is safe and …

This early-phase study tests a new drug called JNJ-87890387 in people with advanced solid tumors that have spread or cannot be removed. The drug is designed to help the immune system attack cancer cells. The main goals are to find a safe dose and to check for side effects. About …

This early-phase study tests an experimental drug called JNJ-89862175 in people with advanced solid tumors (lung, kidney, ovarian, or uterine cancers that have spread). The drug is designed to deliver a toxic payload directly to cancer cells. The main goals are to find a safe dos…

This trial is testing two hormone-based approaches to treat early-stage, grade 2 endometrial cancer in women under 45 who wish to preserve their fertility. One approach uses a daily oral progesterone pill, while the other combines the pill with a hormone-releasing intrauterine de…

This study is testing whether adding the immunotherapy drug camrelizumab to standard chemotherapy before surgery can help shrink advanced endometrial cancer. About 39 women with stage III or IV disease will receive the combination, then undergo surgery. The main goal is to see ho…

This study tests a new drug called mocertatug rezetecan (Mo-Rez) in 450 people with ovarian cancer that has stopped responding to platinum chemotherapy. The goal is to see if Mo-Rez helps people live longer without their cancer growing compared to standard treatments. Researchers…

This study compares two hormone drugs (megestrol acetate and micronized progesterone) in 140 women with endometrial cancer or precancer. Participants take one of the drugs for a short time before their scheduled surgery. Researchers will measure how well each drug slows cancer ce…

This phase 2 trial tests whether combining hormone therapy (letrozole) with a targeted drug (abemaciclib), and possibly adding metformin or gedatolisib, can control estrogen-receptor-positive endometrial cancer that has returned or spread. The study enrolls adults with this cance…

This pilot study is testing whether combining a GLP-1 weight-loss drug (like semaglutide or tirzepatide) with a hormonal IUD can help obese patients with early-stage endometrial cancer avoid surgery or preserve fertility. Twenty participants will receive the drug and IUD, and res…

This early-stage trial tests the safety of combining two drugs, ONC201 and atezolizumab, in 58 women with advanced or recurrent endometrial cancer. The study includes both obese and non-obese participants to see if body weight affects treatment. The goal is to find the best dose …

This study tests a new combination of drugs (sapanisertib and serabelisib, together called PIKTOR) plus standard chemotherapy (paclitaxel) in people with advanced or recurrent endometrial cancer that has not been cured by prior treatments. The goal is to see if this combo can shr…

This study tests a combination of two drugs, nab-sirolimus and letrozole, in 29 people with advanced or recurrent endometrioid endometrial cancer that cannot be removed by surgery. The goal is to see if the combination shrinks tumors or slows cancer growth. Participants take both…

This study compares a shorter course of vaginal cuff brachytherapy (internal radiation) to the standard longer course for people with stage I-II endometrial cancer. The main goal is to see if the shorter treatment improves quality of life and reduces financial burden, while still…

This study looks at the genetics of high-risk endometrial cancer to find out why it sometimes returns after treatment. About 100 adults having surgery at Mayo Clinic will provide tissue and blood samples. Researchers will analyze these samples to build a databank for future studi…

This study is for people with a low-risk type of uterine cancer (endometrial cancer). Researchers want to see if finding very small groups of cancer cells (called isolated tumor cells) in the first lymph nodes near the tumor changes the chance of the cancer coming back. About 212…

This study is testing whether tumor tissue from endometrial cancer patients can be successfully turned into organoids (tiny lab-grown models) after being transported from other hospitals. About 20 adults with endometrial cancer will provide a sample during their standard surgery.…