Drug dependence
MONDO:0005303Drug dependence - replaced the term "drug addiction" and is defined as a state, psychic and sometimes also physical, resulting from the interaction between a living organism and a drug, characterized by behavioral and other responses that always include a compulsion to take the drug on a continuous or periodic basis in order to experience its psychic effects, and sometimes to avoid the discomfort of its absence. Tolerance may or may not be present. A person may be dependent on more than one drug.
Also known as: chemical dependence
1368 clinical trials for this condition and its sub-types, 14 tagged with Drug dependence itself.
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Sub-types of Drug dependence
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Opiate dependence 545 trials
2 sub-types
- Heroin dependence 2 trials
- Morphine dependence 2 trials
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Nicotine dependence 412 trials
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Cannabis dependence 218 trials
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Methamphetamine dependence 63 trials
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Cocaine dependence 52 trials
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Alcohol dependence 44 trials
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Hallucinogen dependence 1 trial
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Alcohol and nicotine codependence 0 trials
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Barbiturate dependence 0 trials
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Phencyclidine abuse 0 trials
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New hope for pregnant women battling opioid addiction: monthly shot vs daily pill
Disease control CompletedThis study tested whether a once-monthly injection of buprenorphine works as well as daily pills to treat opioid use disorder in 140 pregnant women. The goal was to see if the monthly shot could reduce illicit opioid use during pregnancy and after birth. Results help doctors choo…
Phase 3 • Sponsor: T. John Winhusen, PhD • Aim: Disease control
Last updated Jun 27, 2026 13:03 UTC
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Brain zaps may curb meth cravings in small pilot trial
Disease control CompletedThis small pilot study tested whether a type of brain stimulation called transcranial magnetic stimulation (TMS) could help people with methamphetamine use disorder. Nineteen participants received daily TMS sessions for two weeks, then three times a week for two more weeks, while…
Sponsor: Ryan M. Carnahan • Aim: Disease control
Last updated Jun 27, 2026 08:11 UTC
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Phone app and debit card help fight alcohol addiction in new study
Disease control CompletedThis study tested a smartphone-based program that uses rewards, coaching, and breathalyzer tests to help 236 adults with alcohol use disorder reduce drinking. Participants earned money for staying sober, tracked via breath tests and self-reports. The goal was to see if this digit…
Sponsor: DynamiCare Health • Aim: Disease control
Last updated Jun 27, 2026 07:52 UTC
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Mindfulness may help curb drug relapse, small study suggests
Disease control CompletedThis completed study tested a mindfulness-based program (MBS) against standard care in 130 adults recovering from polydrug addiction. The goal was to see if MBS could reduce cravings and relapse risk. Researchers also looked at improvements in emotional control, mood, and motivat…
Sponsor: Institute of Psychology, Chinese Academy of Sciences • Aim: Disease control
Last updated Jun 26, 2026 14:39 UTC
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Exercise program shows promise for drug recovery fitness
Symptom relief CompletedThis study looked at whether a 4-week circuit training program could improve heart and lung fitness in men recovering from drug addiction. Sixty men were split into two groups: one did circuit training (like push-ups, stair climbing, and high knees) three times a week, and the ot…
Sponsor: Riphah International University • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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Baltimore study investigates how neighborhoods shape drug habits
Knowledge-focused CompletedThis completed study looked at how a person's neighborhood environment might influence drug use, addiction, and whether they seek treatment. Over 1,600 adults from Baltimore took part, including people who never used drugs, past users, and current users. Researchers collected hea…
Sponsor: National Institute on Drug Abuse (NIDA) • Aim: Knowledge-focused
Last updated Sep 17, 2026 00:00 UTC
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New study looks inside the womb to see how opioid medications impact unborn babies
Knowledge-focused CompletedThis study looked at pregnant women being treated for opioid use disorder with two different forms of buprenorphine: a monthly shot and a daily tablet. Researchers measured drug levels in the mother's blood and checked the baby's heart rate to see how each treatment affected both…
Sponsor: T. John Winhusen, PhD • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC
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Opioid treatment in pregnancy: which form is safer for Baby's brain?
Knowledge-focused CompletedThis study looked at 71 babies born to mothers who took either a monthly injection or a daily tablet of buprenorphine for opioid use disorder during pregnancy. Researchers measured the babies' thinking, language, and motor skills using a standard child development test. The goal …
Sponsor: T. John Winhusen, PhD • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC