Disease of orbital part of eye adnexa

This study tested a new drug called VRDN-003 in 87 people with thyroid eye disease (TED). The drug is given as a shot under the skin and targets a protein linked to the disease. The main goal was to check safety and how the drug moves through the body, not yet to measure how well…

This study looked at whether tocilizumab, a drug that calms the immune system, can help people with active moderate-to-severe thyroid eye disease that did not get better with steroids. Thirty-two adults received the drug every four weeks. Researchers measured improvements in eye …

This study tested whether using 3D-printed, custom models to plan and guide orbital decompression surgery leads to fewer complications and better outcomes for people with thyroid eye disease. Twelve adults with inactive, moderate-to-severe disease were randomly assigned to receiv…

This study tested a drug called IBI311 in 91 adults with thyroid eye disease, a condition that can cause bulging eyes and discomfort. Participants received an initial high dose followed by several maintenance doses every three weeks. The main goal was to see if the drug could red…

This study tested an investigational drug called VRDN-001 in 143 people with thyroid eye disease who did not improve in earlier studies. The drug aims to reduce inflammation and eye bulging by blocking a specific receptor. Researchers measured how many participants had at least a…

This completed Phase 3 trial tested a drug called VRDN-001 in 231 people with thyroid eye disease (TED). The drug works by blocking a receptor involved in inflammation and swelling. The main goal was to check safety and tolerability, with secondary goals including measuring chang…

This Phase 3 trial tested whether batoclimab, an injected antibody, can reduce eye bulging (proptosis) in people with active, moderate-to-severe thyroid eye disease. 86 participants received weekly injections of batoclimab or a placebo for 24 weeks. The main goal was to see how m…

This study tested a drug called IBI311 in 53 people with thyroid eye disease that did not get better with steroids. The drug is a modified antibody that blocks a specific receptor. The main goal was to see if it could reduce eye bulging. The trial was completed and compared IBI31…

This study tested a new medicine called LASN01 in 41 adults with thyroid eye disease, a condition that causes eye bulging and discomfort. The goal was to see if LASN01 could safely reduce eye bulging compared to a placebo. Participants received either LASN01 or a dummy treatment …

This study looked at how safe and tolerable different lengths of treatment with teprotumumab are for adults with thyroid eye disease (TED). About 313 participants received the drug for varying durations to see if shorter treatment works as well and reduces side effects. The goal …

This Phase 2 trial tested whether injections of aflibercept, a drug that blocks abnormal blood vessel growth, are safe for people with active thyroid eye disease. Eleven adults received three injections over a month, with or without hyaluronidase to help spread the drug. The main…

This Phase 3 trial tested a drug called batoclimab in 114 adults with active, moderate-to-severe thyroid eye disease (TED). Participants received weekly injections of batoclimab or a placebo for 24 weeks. The main goal was to see if the drug could reduce eye bulging (proptosis) b…

This Phase 3 trial tested an investigational drug called veligrotug (VRDN-001) in 188 people with chronic thyroid eye disease. The drug is an antibody that blocks a protein involved in the disease. The main goal was to see if it could reduce eye bulging (proptosis) compared to a …

This Phase II study tested a new biologic drug called IBI311 in 38 people with thyroid eye disease, a condition that causes eye bulging and discomfort. Participants received different doses of the drug to see if it could safely reduce eye protrusion. The trial is completed, and r…

This completed study looked at how well teprotumumab (TEPEZZA) works in real-world use for 5 Chinese patients with thyroid eye disease. The main goal was to see how many patients had a reduction in eye bulging (proptosis) after their last IV infusion. The study also collected bas…

This study tested whether injecting triamcinolone acetonide into the eyelid could help people with thyroid eye disease who have a retracted upper eyelid. Fifteen adults received a combination of two injections and were measured one month later. The goal was to see if the eyelid p…

This completed study from Thomas Jefferson University involved 20 adults with thyroid eye disease and their caregivers. Researchers conducted focus groups and interviews to understand how the condition affects mood, relationships, work, and daily life. Participants also completed…

This study looked at how a surgery called balanced orbital decompression affects blood flow in the eyes of people with inactive thyroid-associated orbitopathy (thyroid eye disease). Researchers measured blood vessel changes in the eye before and after surgery using special imagin…

This completed study looked at 68 adults with thyroid-associated orbitopathy (thyroid eye disease) to see how changes in the eye socket affect blood vessels in the retina. Using a special imaging technique called OCTA, researchers measured vessel density in different layers of th…