Could an eye injection ease thyroid eye disease? small trial tests safety
NCT ID NCT04311606
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This Phase 2 trial tested whether injections of aflibercept, a drug that blocks abnormal blood vessel growth, are safe for people with active thyroid eye disease. Eleven adults received three injections over a month, with or without hyaluronidase to help spread the drug. The main goal was to check for side effects, not to measure how well it works.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- aflibercept (a drug that blocks blood vessel growth), given with either saline or hyaluronidase
- What this could lead to
- If it works, this could point toward a new treatment option for thyroid eye disease that reduces inflammation and eye bulging.
- What could go wrong
- This is a very early, small Phase 2 trial with only 11 people, focused mainly on safety. It may not show clear benefit, and aflibercept injections near the eye carry risks like infection or vision changes.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
-
Mass Eye and Ear
Boston, Massachusetts, 02114, United States
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