New drug shows promise for bulging eyes in thyroid disease
NCT ID NCT06126783
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a drug called IBI311 in 91 adults with thyroid eye disease, a condition that can cause bulging eyes and discomfort. Participants received an initial high dose followed by several maintenance doses every three weeks. The main goal was to see if the drug could reduce eye bulging by at least 2 mm without worsening the other eye. The study also looked at overall response, including reduced inflammation. Because this was an open-label extension, everyone knew they were getting the drug, which can affect results.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
IBI311 (a drug given as an infusion, first dose 10 mg/kg then 20 mg/kg every 3 weeks)
What this could lead to
If it works, this could provide a treatment option to reduce eye bulging and inflammation in people with thyroid eye disease.
What could go wrong
This is an extension study, so it builds on earlier results. It is still relatively small (91 people) and open-label, meaning no placebo group, so results may be less reliable. Possible side effects from the drug are not detailed here.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, 200000, China