New pill could help when steroids fail for bulging eyes
NCT ID NCT07547930
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests an oral medication called tofacitinib in 8 people with moderate-to-severe thyroid eye disease who did not improve with or could not take steroids. The drug works by blocking inflammation pathways. Researchers will check if it reduces eye bulging and other symptoms over 24 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Tofacitinib (a JAK inhibitor pill)
- What this could lead to
- If successful, this could offer a new oral treatment option for people with thyroid eye disease who don't respond to or can't tolerate steroids.
- What could go wrong
- This is a very small, early-phase study with only 8 participants. It may not show clear benefit, and side effects of tofacitinib include infection risk.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
The First Affiliated Hospital of Xiamen University
RECRUITINGXiamen, Fujian, 361003, China
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