Dialysis disequilibrium syndrome

This study tests whether a drug called lanadelumab can prevent sudden drops in blood pressure that often happen during hemodialysis. The trial involves 28 adults on long-term dialysis who are prone to these episodes. Participants receive either the drug or a placebo injection, an…

This study tested whether using a special scale (bioimpedance) to measure body fluid levels each month could help doctors set the right dry weight for hemodialysis patients. The goal was to reduce serious complications like heart attacks, strokes, and low blood pressure during di…

This small completed study looked at a blood filtering procedure called double-filtration plasmapheresis (DFPP) in 5 kidney dialysis patients with very high levels of lipoprotein(a), a fatty substance linked to heart disease and blood clots. The goal was to see if DFPP could lowe…

This study tested a new way to prevent blood clots in the dialysis machine without using heparin, a blood thinner that can cause dangerous bleeding. The method uses a special fluid with citrate and no calcium, and adds calcium back into the body as needed. The study included 97 c…

This study tested a special collagen implant coated with sirolimus (rapamycin) placed around a new dialysis fistula during surgery. The goal was to see if it helps the fistula become usable for dialysis sooner and stay working longer. About 269 people with advanced kidney disease…

This phase 3 trial tests a sirolimus-releasing collagen implant placed around a new dialysis fistula during surgery. The goal is to help the fistula mature faster so it can be used for dialysis. The study involves 136 people aged 65+ with kidney failure who are new to hemodialysi…

This study tested a new device called 'Pure Water Eye' that continuously checks the quality of water used in dialysis machines. Current methods only test water at set times, which can miss sudden dangerous changes like chlorine spikes. The device monitors five key measures (pH, c…

This study tested whether massage and progressive muscle relaxation exercises can reduce the frequency and severity of muscle cramps in people undergoing hemodialysis. 79 patients participated, and the goal was to see if these non-drug approaches offer relief. The findings could …

This study tested whether lowering the temperature of the dialysis fluid from 36.5°C to 36°C could reduce the tiredness patients often feel after dialysis. Fifty-seven adults on maintenance hemodialysis received three sessions of 'cold dialysis' over one week. Researchers measure…

This study tested whether giving mannitol during hemodialysis can prevent blood pressure drops and reduce symptoms like dizziness. Thirty-one adults prone to low blood pressure during dialysis received either mannitol or a saline placebo. The goal was to see if mannitol improves …

This study looked at 40 ICU patients to see if a heart ultrasound before dialysis could predict dangerous drops in blood pressure. Doctors measured heart function using several ultrasound markers. The goal is to help plan safer dialysis for critically ill patients.

This study looked at whether using dialysis less often helps people recover from acute kidney injury that requires dialysis. 220 hospitalized adults were assigned to either a conservative (less frequent) dialysis plan or the usual thrice-weekly schedule. The goal was to see if th…

This study tested whether a simple lung ultrasound can accurately detect fluid overload in people on hemodialysis. 46 patients had an ultrasound before their regular dialysis session, and the results were compared to other standard tests. The goal is to help doctors better determ…