Can a single shot stop dialysis blood pressure crashes?

NCT ID NCT05297786

Completed Disease control Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 30, 2026 · Updated 3 times

Summary

This study tests whether a drug called lanadelumab can prevent sudden drops in blood pressure that often happen during hemodialysis. The trial involves 28 adults on long-term dialysis who are prone to these episodes. Participants receive either the drug or a placebo injection, and researchers monitor blood pressure changes and the number of hypotensive events.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Lanadelumab (Takhzyro)
What this could lead to: If it works, this could offer a new way to prevent blood pressure drops during dialysis, making treatment safer and more comfortable for kidney patients.
What could go wrong: This is a small, early-phase trial with only 28 participants, so results may not apply to everyone. The drug may not work better than placebo, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

dialysis disequilibrium syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEMODIALYSIS COMPLICATION HYPOTENSION OF HEMODIALYSIS

Contacts and locations

Locations

Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States

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