Diabetic macular edema

This study looks at whether switching to a higher-dose eye injection called aflibercept 8 mg can allow people with neovascular age-related macular degeneration (nAMD) or diabetic macular oedema (DME) to go longer between treatments. It follows adults in Portugal who have already …

This trial tests whether faricimab, an eye injection, can improve vision and reduce swelling in South Asian patients with diabetic macular edema (DMO), a complication of diabetes that can lead to blindness. Previous studies mostly included Caucasian or East Asian participants, le…

This phase 3 trial compares an experimental drug, tabirafusp tedromer, against the standard treatment aflibercept for people with diabetic macular edema (DME), a leading cause of vision loss in diabetes. About 910 adults with DME will receive injections into the eye and be follow…

This phase 3 trial tests whether an experimental drug called MK-8748 can treat diabetic macular edema (DME), a condition where fluid builds up in the retina and blurs vision. About 960 adults with DME will receive either MK-8748 or the standard treatment aflibercept via eye injec…

This phase 3 trial compares an experimental drug, MK-8748, to the standard treatment aflibercept for diabetic macular edema (DME), a condition where fluid buildup in the retina blurs vision. About 1,100 adults with diabetes and vision loss from DME receive either MK-8748 or aflib…

This study tests whether two dietary supplements—tauroursodeoxycholate (a bile acid) and a traditional Chinese medicine formula—can help people with diabetic macular edema, a vision-threatening complication of diabetes. The 69 participants will take the supplements or a placebo f…

This study tests whether a treat-and-extend schedule for aflibercept eye injections works better than the standard as-needed approach for people with diabetic macular edema who have not had prior treatment. About 186 participants will receive three monthly injections, then either…

This pilot study tests whether a daily probiotic supplement (Lactobacillus plantarum 299v) can reduce retinal swelling and improve vision in people with diabetic macular edema. Thirty-six participants will take the probiotic twice daily for four months. Researchers will measure c…

This Phase 1 trial will test the safety of PRO-169, a form of bevacizumab injected into the eye, in 60 adults with diabetic macular edema. The study checks for immune reactions and side effects. It is not yet recruiting and focuses on safety, not whether it improves vision.

This study tests an oral medication, CU06-1004, for people with diabetic macular edema (DME), a condition that causes vision loss. About 156 participants will take either a low dose, high dose, or placebo pill daily for 24 weeks. The goal is to see if the drug improves vision and…

This study compares a combination of a steroid implant (dexamethasone) plus an anti-VEGF injection (aflibercept) against aflibercept alone for diabetic macular edema. Researchers will enroll 114 people with diabetes who have not had prior treatment. The goal is to see if the comb…

This study looks at whether a single injection of the drug Aflibercept given during cataract surgery works as well as three injections (one during surgery and two more over the next two months) to stop diabetic retinopathy from getting worse. The trial will include 166 diabetic p…

This study tests two different laser pulse settings (5% vs 15% duty cycle) in 50 adults with diabetic macular edema, a common cause of vision loss in diabetes. The goal is to see which setting is safer and more effective at reducing retinal swelling. Participants must have mild t…

This early-stage study tests a new nose spray version of the drug octreotide for people with diabetic macular edema, a condition that causes vision loss from fluid buildup in the eye. The trial will include 60 adults whose eye swelling has not improved with standard treatments. R…

This study tests an experimental drug called SNP318 in 60 people with diabetic macular edema, a condition that causes vision loss due to swelling in the retina. Participants will receive either the drug or a placebo, and researchers will monitor safety, eye thickness, and vision …

This trial tests an artificial intelligence system called QiLin that helps doctors decide when to give anti-VEGF injections for retinal diseases like wet AMD, DME, and RVO. About 200 patients who have completed initial treatment will be randomly assigned to have their doctor use …

This study will test a new, non-invasive eye scanner called wide field OCTA in 200 people with various eye diseases, including age-related macular degeneration, diabetic retinopathy, and dry eye. The goal is to see if this device can provide better images of blood vessels in the …

This study tests if using a cotton-tipped applicator to hold the eyelid open during eye injections is less painful and faster than the standard metal speculum. About 120 adults with certain eye conditions will take part. The goal is to improve comfort and satisfaction without com…

This study will test a new, noninvasive camera called XyCAM CRE that measures blood flow in the back of the eye. Researchers will compare its images with standard eye tests in 350 adults with retinal disorders. The goal is to see if this camera can provide extra information to he…

This study will use artificial intelligence (AI) to analyze eye scans from 554 adults with diabetic macular edema (DME). The goal is to see if AI can predict when a person's eye treatment needs to change. Participants will not receive any new treatment; instead, researchers will …

This study tests whether a personalized care approach helps patients with chronic macular diseases (like wet age-related macular degeneration and diabetic macular edema) attend their regular eye injection appointments. Many patients skip these vital treatments, risking further vi…

This study follows 100 adults with diabetic eye disease who are already receiving standard anti-VEGF injections for swelling in the center of the retina. Researchers will use advanced vision tests and imaging to track changes over time. The goal is not to test a new drug, but to …

This study will analyze eye and brain scans from over 200,000 people to see if eye images can predict brain diseases like small vessel disease and other health problems. Researchers will build computer models to map eye features to brain structure and disease diagnoses. No treatm…

This study aims to understand how dry eye disease and diabetic macular edema (a swelling in the back of the eye) are related in people with diabetes. About 50 adults with diabetes for over 8 years will have their eyes tested using questionnaires, tear measurements, and imaging. T…

This study will use a special eye scan called OCT to look for early signs of retinal damage in people with diabetes who have no vision problems. Researchers want to see if these scans can detect changes before symptoms appear. About 112 participants will get a detailed eye exam, …