Congenital heart malformation

This study follows people with moderate to severe pulmonary regurgitation or stenosis who receive the PULSTA transcatheter pulmonary valve, a less invasive option for replacing a faulty heart valve. Researchers will track how well the valve works over time, measuring improvements…

This trial tests a new type of stent that dissolves over time for children under 9 with narrowed arteries in or near the heart. The stent opens the vessel and then gradually disappears, allowing the artery to grow naturally. The study will enroll 45 children and follow them for 5…

This study looks at a device called the Occlutech Atrial Flow Regulator (AFR) in 25 people whose Fontan circulation (a surgery for a heart defect) is failing. The goal is to see if the device is safe and works well to create a small hole between heart chambers to improve blood fl…

This phase 2 trial tests whether secukinumab, a drug that blocks IL-17A, can help people with active severe Takayasu arteritis achieve remission and stop taking steroids. About 52 participants will receive either secukinumab injections or standard care (like TNF inhibitors). The …

This study tests two new drugs, vunakizumab and ivarmacitinib, for people with active Takayasu arteritis (TAK), a rare disease that causes inflammation in large blood vessels. The trial will enroll 180 adults aged 18-70 whose disease is still active despite standard treatments. R…

This study will test a special balloon coated with the drug paclitaxel to treat long blockages in the leg arteries. About 300 people with severe leg pain or wounds will receive the balloon treatment during a standard angioplasty procedure. Researchers will track how well the arte…

This study tests whether adding pirfenidone, a drug used for lung and liver scarring, to standard treatment can improve blood vessel damage in people with Takayasu arteritis. About 92 adults aged 18-60 will receive either pirfenidone or a placebo for 6 months. The goal is to see …

This study will test whether adding a special breathing exercise (inspiratory muscle training) to standard cardiac rehab helps heart patients recover better. About 80 adults who have been hospitalized for a heart condition will take part. The main goal is to see if the training i…

This study will test a new type of PET/CT scanner, called Long-Axial Field-of-View (LAFOV), to see if it can provide clearer images of blood vessel inflammation in people with large vessel vasculitis (LVV). The scanner is more sensitive and can image the whole body faster, potent…

This study looks at how CT scans can help doctors identify heart and blood vessel problems in children with Tetralogy of Fallot, a serious heart condition present at birth. About 37 children up to 12 years old will get a CT scan to find hidden issues and help plan surgery. The go…

This study looks at whether adding special breathing exercises to aerobic training can improve lung function, exercise ability, and quality of life in adults who had surgery for Tetralogy of Fallot, a heart condition. Sixty participants will be split into two groups: one does bre…

This study investigates how often muscle relaxants used during general anesthesia remain in the body after surgery, a condition called residual neuromuscular blockade. It will follow 160 adults aged 18-90 who are scheduled for post-anesthesia care unit admission after elective su…

This study is building a biobank of blood samples and imaging data from 300 people with suspected inflammatory heart or autoimmune rheumatic diseases. Researchers aim to identify immune biomarkers that could predict major heart events like heart failure, stroke, or atrial fibrill…

This study looks at heart function and rhythm in children and young adults up to age 25 who have had surgery to repair Tetralogy of Fallot, a congenital heart defect. Researchers will use echocardiography, a 12-lead ECG, and Holter monitoring to detect changes such as arrhythmias…

This study checks whether three common ECG-based methods can accurately locate where abnormal heart rhythms start in adults who had Tetralogy of Fallot repair. Researchers will pace the heart from known spots during a scheduled procedure and compare the predicted location to the …

This study will test whether a special ultrasound score, called OTUS, can accurately track disease activity in people with Takayasu arteritis, a rare condition that causes inflammation of the large arteries. Researchers will follow 100 patients with active disease, performing ult…