Cold urticaria
MONDO:0022799Cold urticaria is a condition that affects the skin. Signs and symptoms generally include reddish, itchy welts (hives) and/or swelling when skin is exposed to the cold (i.e. cold weather or swimming in cold water). This rash is usually apparent within 2-5 minutes after exposure and can last for 1-2 hours. The exact cause of cold urticaria is poorly understood in most cases. Rarely, it may be associated with an underlying blood condition or infectious disease. Treatment generally consists of patient education, avoiding exposures that may trigger a reaction, and/or medications.
Also known as: cold contact urticaria, primary idiopathic cold urticaria, urticaria idiopathic cold
10 clinical trials for this condition and its sub-types.
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New shot may stop hives from cold and scratching
Disease control Recruiting nowThis study tests an investigational drug called barzolvolimab in 240 adults who get hives from cold temperatures or from scratching their skin, and whose symptoms are not controlled by standard allergy pills. Participants receive either the drug or a placebo injection, and doctor…
Phase: PHASE3 • Sponsor: Celldex Therapeutics • Aim: Disease control
Last updated Jul 31, 2026 00:00 UTC
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New pill could tame stubborn hives
Disease control Recruiting nowThis study tests a new drug called remibrutinib (a tablet) against a placebo in 44 adults with chronic hives (either spontaneous or triggered by things like pressure or cold). The goal is to see if it reduces symptoms like itching and burning, and how it works in the body. Partic…
Phase: PHASE2 • Sponsor: Novartis Pharmaceuticals • Aim: Disease control
Last updated Jul 17, 2026 00:00 UTC
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New drug aims to calm stubborn hives triggered by cold or scratching
Symptom relief Recruiting nowThis early-stage study tests a single dose of an experimental drug called GTX-B001 in healthy people and those with chronic inducible urticaria—a condition where cold or scratching causes painful hives. The main goal is to check safety and how the body handles the drug. About 72 …
Phase: PHASE1 • Sponsor: Granular Therapeutics Limited • Aim: Symptom relief
Last updated Jun 27, 2026 09:00 UTC
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Scientists hunt for clues to better diagnose triggered hives
Knowledge-focused Recruiting nowThis study aims to find biological markers (biomarkers) that can help diagnose and monitor chronic induced urticaria (CIndU), a condition where specific triggers like cold or pressure cause itchy hives or swelling. Researchers will compare 40 participants—including people with CI…
Sponsor: Centre for Human Drug Research, Netherlands • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC