Cold urticaria
MONDO:0022799Cold urticaria is a condition that affects the skin. Signs and symptoms generally include reddish, itchy welts (hives) and/or swelling when skin is exposed to the cold (i.e. cold weather or swimming in cold water). This rash is usually apparent within 2-5 minutes after exposure and can last for 1-2 hours. The exact cause of cold urticaria is poorly understood in most cases. Rarely, it may be associated with an underlying blood condition or infectious disease. Treatment generally consists of patient education, avoiding exposures that may trigger a reaction, and/or medications.
Also known as: cold contact urticaria, primary idiopathic cold urticaria, urticaria idiopathic cold
10 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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New pill could stop hives from scratching or cold
Disease control CompletedThis phase 2a trial tested an oral drug called EVO756 in 30 adults with chronic inducible urticaria, a condition where physical triggers like scratching or cold cause hives. The study aimed to see if the drug is safe and can reduce wheals. Results are not yet available.
Phase: PHASE2 • Sponsor: Evommune, Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:36 UTC
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New shot could tame stubborn hives that antihistamines Can't stop
Disease control CompletedThis Phase 2 study tested a drug called barzolvolimab (CDX-0159) in 196 adults with chronic inducible urticaria—hives triggered by cold or scratching—that persist despite antihistamines. Participants received either the drug or a placebo as a shot under the skin. The main goal wa…
Phase: PHASE2 • Sponsor: Celldex Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 07:56 UTC
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New shot could stop cold hives
Disease control CompletedThis study tested dupilumab, an injectable drug, in 82 people with cold urticaria (hives triggered by cold) who still had symptoms despite taking antihistamines. The goal was to see if dupilumab could prevent hives after an ice cube test and improve quality of life. Participants …
Phase: PHASE3 • Sponsor: Sanofi • Aim: Disease control
Last updated Jun 26, 2026 16:22 UTC