New shot could tame stubborn hives that antihistamines Can't stop
NCT ID NCT05405660
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 2 study tested a drug called barzolvolimab (CDX-0159) in 196 adults with chronic inducible urticaria—hives triggered by cold or scratching—that persist despite antihistamines. Participants received either the drug or a placebo as a shot under the skin. The main goal was to see if the drug could prevent hives from forming during a provocation test after 12 weeks. The trial is complete, and results may show whether this biologic offers a new option for people with hard-to-control hives.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
barzolvolimab (CDX-0159), a biologic drug given as a shot under the skin
What this could lead to
If it works, this could point toward a new treatment for people with chronic inducible urticaria who still have symptoms despite antihistamines.
What could go wrong
This is a Phase 2 trial, so it is still early. The drug may not prove effective or safe enough for larger studies or approval. Side effects are possible.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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"LOR" Clinic
Riga, LV-1004, Latvia
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"Medical Center Ekselsior" OOD
Sofia, Bulgaria
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"University Multiprofile Hospital for Active Treatment 'Aleksandrovska" EAD, Clinic of Clinical Allergology
Sofia, Bulgaria
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Allergo-Derm Bakos Kft
Szolnok, 5000, Hungary
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Allergy & Asthma Consultants
Redwood City, California, 94063, United States
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Allergy & Asthma Specialists, PSC
Owensboro, Kentucky, 42301, United States
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Allergy Associates of Utah
Murray, Utah, 84107, United States
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Allergy Partners of Kerrville
Kerrville, Texas, 78028, United States
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Allervie Clinical Research
Montgomery, Alabama, 36106, United States
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Balvi and Gulbene Hospital Union
Balvi, LV-4501, Latvia
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Center of Allergy Diagnosis and Treatment
Vilnius, LT-09109, Lithuania
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Center of Allergy and Immunology
Tbilisi, 0159, Georgia
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Centrum Medyczne PLEJADY
Krakow, 30-363, Poland
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Children Clinical University Hospital
Riga, LV-1004, Latvia
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Clinical Research Center of Alabama
Birmingham, Alabama, 35249, United States
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Consilium Medicum
Riga, LV-1010, Latvia
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Dawes Fretzin Dermatology Group, LLC
Indianapolis, Indiana, 46250, United States
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Debreceni Egyetem Klinikai Központ (DEKK), Bőrgyógyászati Klinika
Debrecen, H-4032, Hungary
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Dr PJ Sebastian
Durban, KwaZulu-Natal, 4092, South Africa
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East Tallin Central Hospital
Tallinn, 11312, Estonia
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Elbe Klinikum Buxtehude
Buxtehude, Lower Saxony, 21614, Germany
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FCRN Clinical Trial Centre Vaal Triangle
Vereeniging, Gauteng, 1935, South Africa
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HGU de Alicante
Alicante, 03010, Spain
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Hannover Medical University
Hanover, Lower Saxony, 30625, Germany
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Healthy Future
Tbilisi, 0119, Georgia
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High Technology Hospital Medcenter
Batumi, 6000, Georgia
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Hospital Arnau de Vilanova
Valencia, 46015, Spain
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Hospital Bellvitge
Barcelona, 8907, Spain
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Hospital Regional Universitario de Málaga
Málaga, 29009, Spain
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Hospital Vall d´ Hebron
Barcelona, 9035, Spain
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IMMUNOe Research Centers
Centennial, Colorado, 80112, United States
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Iatros International
Bloemfontein, Free State, 9324, South Africa
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Institute for Asthma and Allergy, PC/Department of Clinical Research
Chevy Chase, Maryland, 20815, United States
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Institute of Allergology IFA
Berlin, 12203, Germany
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JSC Ausros Medicinos Centras
Kaunas, 49387, Lithuania
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JSC Inlita
Vilnius, 08406, Lithuania
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Kern Research, Inc
Bakersfield, California, 93301, United States
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Klinika Ambroziak sp. z o.o.
Warsaw, 02-953, Poland
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Klinikum Oldenburg gGmbH - Klinik f. Dermatologie u. Allergologie
Oldenburg, Lower Saxony, 26133, Germany
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LMU Klinikum - Klinik und Poliklinik für Dermatologie und Allergologie DASZ-Dermato-Allergologisches Studien Zentrum
München, Bavaria, 80337, Germany
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Little Rock Allergy & Asthma CRC
Little Rock, Arkansas, 72205, United States
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Luxderm Specjalistyczny Gabinet Dermatologiczny Prof. Doroty Krasowskiej
Lublin, 20-573, Poland
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Malopolskie Centrum Alergologii
Krakow, 31-624, Poland
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Medical Center "SYNEXUS SOFIA", EOOD
Sofia, Bulgaria
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Medical Center Iskar- EOOD Office of Clinical Allergology
Sofia, 1504, Bulgaria
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Medicome Sp. z o.o.
Oświęcim, 32600, Poland
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Medicover Integrated Clinical Services Sp. zo.o.
Torun, 87-100, Poland
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Multiprofile Clinic Consilium Medulla
Tbilisi, 0186, Georgia
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Newtown Clinical Research
Johannesburg, Gauteng, 2113, South Africa
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One of a Kind Clinical Research Center, LLC
Paradise Valley, Arizona, 85253, United States
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Outpatient Clinic for Individual Practice for Specialized Outpatient
Razgrad, 7200, Bulgaria
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Pauls Stradins Clinical University Hospital
Riga, LV-1002, Latvia
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Respiratory Medicine Research Institute of Michigan, PLC
Ypsilanti, Michigan, 48197, United States
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Sarasota Clinical Research
Sarasota, Florida, 34239, United States
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Semmelweis Egyetem, ÁOK, Bőr-, Nemikórtani és Bőronkológiai Klinika
Budapest, 1085, Hungary
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Semmelweis Egyetem, ÁOK, Bőr-, Nemikórtani és Bőronkológiai Klinika
Budapest, Hungary
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Synapta Clinical Research
Durban, KwaZulu-Natal, 4001, South Africa
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The University of Cape Town - Lung Institute
Cape Town, Mowbray, 7700, South Africa
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Treasure Valley Medical Research
Boise, Idaho, 83706, United States
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Ubuntu Clinical Research
Lenasia, Gauteng, 1827, South Africa
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Universidad de Navarra
Madrid, 28027, Spain
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Universitaetsklinikum Giessen u. Marburg GmbH
Marburg, Hesse, 35043, Germany
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University Multiprofile Hospital for Active Treatment "Prof. Dr. Stoyan Kirkovich" AD
Stara Zagora, Bulgaria
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University of Cincinnati
Cincinnati, Ohio, 45267, United States
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Universitätsklinikum Augsburg
Augsburg, Bavaria, 86179, Germany
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Universitätsklinikum Dresden
Dresden, Saxony, 01307, Germany
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Universitätsklinikum Düsseldorf - Dermatologie
Düsseldorf, North Rhine-Westphalia, 40225, Germany
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Universitätsklinikum Essen Klinikum f. Dermatologie, Venerologie u. Allergologie Hufelandstr
Essen, North Rhine-Westphalia, 45122, Germany
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Universitätsklinikum Heidelberg - Dermatologie
Heidelberg, 69120, Germany
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Universitätsklinikum Münster Klinik u. Poliklinik f. Dermatologie
Münster, North Rhine-Westphalia, 48149, Germany
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Universitätsklinikum Schleswig-Holstein - Zentrum für entzündliche Hauterkrankungen
Kiel, Schleswig-Holstein, 24105, Germany
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Uniwersytecki Szpital Kliniczny nr 1 w Lodzi
Lodz, 90-153, Poland
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Uniwersytecki Szpital Kliniczny w Opolu, Pododdział Chorób Wewnętrznych i Alergologii
Opole, 45-401, Poland
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Vahlberg & Pild Clinic
Tallinn, 10134, Estonia
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WorthWhile Clinical Trials
Benoni, Gauteng, 1500, South Africa
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Óbudai Egészségügyi Centrum
Zalaegerszeg, 8900, Hungary