Central sleep apnea syndrome
MONDO:0004731A broad classification of disorders which includes 6 subtypes (primary central sleep apnea, central sleep apnea due to Cheyne-Stokes breathing pattern, central sleep apnea due to medical condition not Cheyne-Stokes, central sleep apnea due to high-altitude periodic breathing, central sleep apnea due to drug or substance and primary sleep apnea of infancy) that are each characterized by interruptions in breathing while asleep. It is caused by improper signaling from the brainstem to respiratory muscles and is triggered by either hypoventilation or hyperventilation. In adults, this disorder may arise following a stroke, congestive heart failure, trauma, infection or the use of narcotic medications. It is more common in older males and may present as a co-morbid condition to obesity. Clinical signs include snoring, insomnia or hypersomnia, difficulty concentrating and fatigue. Recurrent episodes of hypoxia/hypoxemia have long-term detrimental effects on cardiovascular health.
Also known as: central sleep apnea syndrome, central sleep apnea, primary, primary central sleep apnea, secondary central sleep apnea, Apneas, central, Apneas, central sleep, Breathings, central sleep-disordered, alveolar hypoventilation, central
51 clinical trials for this condition and its sub-types.
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Broader categories
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Could a ring on your finger replace the sleep lab?
Diagnosis OngoingThis study is testing whether a wearable ring and a small body sensor can accurately diagnose sleep-disordered breathing, including sleep apnea. About 79 adults with suspected sleep apnea will wear the devices during an overnight sleep lab test. The goal is to see if the ring's r…
Phase: NA • Sponsor: Belun Technology Company Limited • Aim: Diagnosis
Last updated Jun 27, 2026 11:03 UTC
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New wearable device aims to track infant breathing pauses during sleep
Diagnosis TerminatedThis study planned to test a new wearable wireless device that wraps around a child's abdomen to monitor central sleep apnea. It would have involved 15 children aged 1 month to 5 years already undergoing standard sleep studies. The device's accuracy and comfort would have been co…
Sponsor: Sheffield Children's NHS Foundation Trust • Aim: Diagnosis
Last updated Jun 27, 2026 11:00 UTC
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Could your blanket track your sleep? smart duvet tested in sleep lab
Diagnosis OngoingThis study tests a new 'intelligent duvet' called Easy Sleep Monitoring (ESM) that uses built-in sensors to detect movement and estimate sleep. Researchers will compare its accuracy to standard sleep lab tests (video-polysomnography) in 50 people, including those with sleep disor…
Phase: NA • Sponsor: University Hospital, Clermont-Ferrand • Aim: Diagnosis
Last updated Jun 27, 2026 07:52 UTC
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New drug combo targets breathing pauses in sleep apnea
Symptom relief OngoingThis Phase 2A study tests three drugs—sivopixant, acetazolamide, and SASS-001—in 60 adults with sleep apnea that has a central component (where the brain fails to signal breathing). The goal is to see if these drugs can reduce the number of breathing pauses during sleep. Particip…
Phase: PHASE2 • Sponsor: Shionogi • Aim: Symptom relief
Last updated Jun 27, 2026 12:29 UTC
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Brain chemical dopamine linked to sleep apnea risk in new study
Knowledge-focused ENROLLING_BY_INVITATIONThis study looks at whether dopamine levels and certain genes affect the risk and severity of sleep breathing disorders like sleep apnea. Researchers will monitor 100 adults overnight and take blood samples to measure dopamine and check for genetic variations. The goal is to bett…
Sponsor: Wroclaw Medical University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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New breath test could replace painful lung scopes
Knowledge-focused ENROLLING_BY_INVITATIONThis study aims to see if a simple, non-invasive breathing test can accurately measure the acidity (pH) in the airways, which is often abnormal in lung diseases. Researchers will compare results from this breath test with standard methods in 150 healthy volunteers and people with…
Phase: PHASE2 • Sponsor: Indiana University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:03 UTC
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Could a sleep apnea machine boost heart efficiency? new study investigates
Knowledge-focused OngoingThis study looks at whether long-term use of a breathing device called adaptive servo-ventilation (ASV) can improve how the heart uses energy and how nerves work in people with heart failure and sleep apnea. Researchers will use PET scans to measure heart metabolism and nerve fun…
Phase: NA • Sponsor: Ottawa Heart Institute Research Corporation • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC