Central sleep apnea syndrome
MONDO:0004731A broad classification of disorders which includes 6 subtypes (primary central sleep apnea, central sleep apnea due to Cheyne-Stokes breathing pattern, central sleep apnea due to medical condition not Cheyne-Stokes, central sleep apnea due to high-altitude periodic breathing, central sleep apnea due to drug or substance and primary sleep apnea of infancy) that are each characterized by interruptions in breathing while asleep. It is caused by improper signaling from the brainstem to respiratory muscles and is triggered by either hypoventilation or hyperventilation. In adults, this disorder may arise following a stroke, congestive heart failure, trauma, infection or the use of narcotic medications. It is more common in older males and may present as a co-morbid condition to obesity. Clinical signs include snoring, insomnia or hypersomnia, difficulty concentrating and fatigue. Recurrent episodes of hypoxia/hypoxemia have long-term detrimental effects on cardiovascular health.
Also known as: central sleep apnea syndrome, central sleep apnea, primary, primary central sleep apnea, secondary central sleep apnea, Apneas, central, Apneas, central sleep, Breathings, central sleep-disordered, alveolar hypoventilation, central
51 clinical trials for this condition and its sub-types.
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Broader categories
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New sensor could help preterm babies breathe easier
Diagnosis Not yet recruitingExtremely preterm infants often have breathing issues that current monitors may miss. This study tests a wireless acoustic sensor placed on the baby's throat to more accurately detect pauses, shallow breaths, and irregular patterns. Researchers will compare the sensor to standard…
Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre • Aim: Diagnosis
Last updated Jun 27, 2026 12:32 UTC
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Smart mask could replace sleep lab tests for apnea patients
Diagnosis Not yet recruitingThis study tests a smart mask that uses AI to detect sleep stages and breathing-related arousals in adults with sleep apnea. About 150 participants will wear the mask during an overnight sleep study, and its results will be compared to standard lab tests. If accurate, the mask co…
Phase: NA • Sponsor: Pathway Medtech, LLC. • Aim: Diagnosis
Last updated Jun 26, 2026 18:15 UTC
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Can a narcolepsy drug fix ICU sleep problems?
Symptom relief Not yet recruitingThis study tests whether a drug called gamma-hydroxybutyrate (GHB) can help intensive care patients get better deep sleep. Sleep problems are very common in the ICU and can lead to serious issues like confusion and longer recovery. The trial will give GHB or a placebo to 24 adult…
Phase: PHASE2 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Symptom relief
Last updated Jun 27, 2026 12:36 UTC
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Can a bedtime pill fix sleep troubles in kids with anorexia?
Symptom relief Not yet recruitingThis study tests a slow-release melatonin (PedPRM) in 120 children aged 6 to 18 who have anorexia nervosa and trouble sleeping. Participants take either melatonin or a placebo for 13 weeks. The goal is to see if it safely improves total sleep time and related symptoms like anxiet…
Phase: PHASE3 • Sponsor: Assistance Publique Hopitaux De Marseille • Aim: Symptom relief
Last updated Jun 27, 2026 12:30 UTC
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Sleep therapy could be key to preventing suicide in young adults
Symptom relief Not yet recruitingThis study looks at whether adding sleep-focused treatments to standard psychiatric care can reduce suicide risk in young adults. About 90 college students with suicidal thoughts and sleep problems will be randomly assigned to one of three sleep interventions. Researchers will tr…
Phase: NA • Sponsor: University of Pittsburgh • Aim: Symptom relief
Last updated Jun 27, 2026 12:08 UTC
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Cartoons and stories soothe Kids' fear during breathing treatments
Symptom relief Not yet recruitingThis study looks at whether watching cartoons or listening to breath-synchronized interactive stories can help children aged 6-9 feel less afraid and more comfortable while using a nebulizer for breathing medication. About 96 children with respiratory conditions will be randomly …
Phase: NA • Sponsor: Mersin University • Aim: Symptom relief
Last updated Jun 27, 2026 12:04 UTC
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Cold therapy could take the ouch out of blood tests
Symptom relief Not yet recruitingThis study tests if applying cold (cryotherapy) to the wrist before a blood draw from the artery can reduce pain. It involves 258 adults with chronic respiratory diseases who need this test. The goal is to find a simple, drug-free way to make the procedure less painful.
Phase: PHASE3 • Sponsor: University Hospital, Brest • Aim: Symptom relief
Last updated Jun 27, 2026 09:04 UTC
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New pain block could spare kids opioids after tonsil surgery
Symptom relief Not yet recruitingThis study tests whether a nerve block (injecting numbing medicine near the cheekbone) can control pain after tonsillectomy in children aged 3-9, reducing the need for opioids. Sixty kids having tonsil surgery for sleep apnea will be randomly assigned to get either the nerve bloc…
Phase: NA • Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's • Aim: Symptom relief
Last updated Jun 27, 2026 08:03 UTC
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Will jaw surgery breathing problems fix themselves? new study aims to find out
Knowledge-focused Not yet recruitingThis study follows 60 adults who had jaw surgery (maxillomandibular advancement) for obstructive sleep apnea. Some develop central or mixed sleep apneas after surgery, and researchers want to see if these breathing issues get better, stay the same, or get worse over a year. Parti…
Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:35 UTC
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New study aims to crack the code on Hard-to-Treat sleep apnea in heart failure
Knowledge-focused Not yet recruitingThis study looks at why people with heart failure or those taking opioid painkillers develop central sleep apnea (pauses in breathing during sleep). Current treatments don't work well, so researchers will test combinations of breathing machines and medications in 200 Veterans. Th…
Phase: PHASE4 • Sponsor: VA Office of Research and Development • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:08 UTC