Central nervous system neoplasm
MONDO:0006130A benign or malignant, primary or metastatic neoplasm that affects the brain, meninges, or spinal cord. Representative examples of primary neoplasms include astrocytoma, oligodendroglioma, ependymoma, and meningioma. Representative examples of metastatic neoplasms include carcinoma and leukemia.
Also known as: CNS neoplasm, CNS tumor, CNS tumour, brain/spinal cord tumor, brain/spinal cord tumour, central nervous system neoplasm, central nervous system neoplasm (disease), central nervous system tumor
3348 clinical trials for this condition and its sub-types, 51 tagged with Central nervous system neoplasm itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Central nervous system neoplasm
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Central nervous system cancer 130 trials · 1,699 incl. sub-types
20 sub-types
- Malignant glioma 250 trials · 915 incl. sub-types Sub-types →
- Brain cancer 680 trials · 900 incl. sub-types Sub-types →
- Primary central nervous system lymphoma 92 trials · 103 incl. sub-types Sub-types →
- Central nervous system sarcoma 2 trials · 74 incl. sub-types Sub-types →
- Spinal cord cancer 21 trials · 57 incl. sub-types Sub-types →
- Central nervous system primitive neuroectodermal neoplasm 8 trials · 24 incl. sub-types Sub-types →
- Central nervous system Ewing sarcoma/peripheral primitive neuroectodermal tumor 1 trial · 22 incl. sub-types Sub-types →
- Malignant tumor of meninges 0 trials · 14 incl. sub-types Sub-types →
- Malignant adrenal gland pheochromocytoma 11 trials
- Central nervous system germinoma 2 trials · 4 incl. sub-types Sub-types →
- Central nervous system melanocytic neoplasm 1 trial · 4 incl. sub-types Sub-types →
- Central nervous system endodermal sinus tumor 0 trials · 1 incl. sub-types Sub-types →
- Choriocarcinoma of the central nervous system 0 trials Sub-types →
- Embryonal carcinoma of the central nervous system 0 trials Sub-types →
- Malignant carotid body paraganglioma 0 trials
- Malignant central nervous system mesenchymal, non-meningothelial neoplasm 0 trials Sub-types →
- Malignant jugulotympanic paraganglioma 0 trials
- Mixed germ cell tumor of central nervous system 0 trials Sub-types →
- Pheochromocytoma/paraganglioma syndrome 2 0 trials
- Pheochromocytoma/paraganglioma syndrome 5 0 trials
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Brain neoplasm 246 trials · 1,077 incl. sub-types
17 sub-types
- Brain cancer 680 trials · 900 incl. sub-types Sub-types →
- Cerebellar neoplasm 3 trials · 114 incl. sub-types Sub-types →
- Infratentorial neoplasm 6 trials · 114 incl. sub-types Sub-types →
- Brainstem neoplasm 0 trials · 101 incl. sub-types Sub-types →
- Primary brain neoplasm 87 trials · 92 incl. sub-types Sub-types →
- Hypothalamic neoplasm 3 trials · 85 incl. sub-types Sub-types →
- Pineal body neoplasm 4 trials · 22 incl. sub-types Sub-types →
- Benign neoplasm of brain 16 trials · 21 incl. sub-types Sub-types →
- Choroid plexus neoplasm 5 trials · 18 incl. sub-types Sub-types →
- Neoplasm of cerebral hemisphere 3 trials · 14 incl. sub-types Sub-types →
- Optic pathway glioma 11 trials Sub-types →
- Olfactory nerve neoplasm 0 trials · 4 incl. sub-types Sub-types →
- Cerebellopontine angle tumor 1 trial Sub-types →
- Dysembryoplastic neuroepithelial tumor 1 trial
- Childhood brain meningioma 0 trials
- Olfactory groove meningioma 0 trials
- Optic tract meningioma 0 trials Sub-types →
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Tumor of meninges 1 trial · 123 incl. sub-types
5 sub-types
- Meningioma 108 trials · 122 incl. sub-types Sub-types →
- Malignant tumor of meninges 0 trials · 14 incl. sub-types Sub-types →
- Benign neoplasm of meninges 0 trials · 5 incl. sub-types Sub-types →
- Diffuse leptomeningeal melanocytosis 0 trials
- Familial multiple meningioma 0 trials
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Central nervous system hematopoietic neoplasm 0 trials · 107 incl. sub-types
4 sub-types
- Primary central nervous system lymphoma 92 trials · 103 incl. sub-types Sub-types →
- Central nervous system leukemia 4 trials
- Intracranial cavernous angioma 0 trials
- Pituitary gland basophil adenoma 0 trials
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Spinal cord neoplasm 36 trials · 77 incl. sub-types
8 sub-types
- Spinal cord cancer 21 trials · 57 incl. sub-types Sub-types →
- Childhood spinal cord tumor 1 trial
- Benign neoplasm of spinal cord 0 trials Sub-types →
- Cervicomedullary junction neoplasm 0 trials
- Conus medullaris neoplasm 0 trials
- Neurofibroma of spinal cord 0 trials
- Spinal cord dermoid cyst 0 trials
- Spinal meningioma 0 trials
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Autonomic nervous system neoplasm 0 trials · 60 incl. sub-types
3 sub-types
- Paraganglioma 53 trials · 57 incl. sub-types Sub-types →
- Ganglioneuroma 5 trials Sub-types →
- Sympathetic neurilemmoma 0 trials
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Central nervous system organ benign neoplasm 1 trial · 57 incl. sub-types
13 sub-types
- Craniopharyngioma 29 trials Sub-types →
- Benign neoplasm of brain 16 trials · 21 incl. sub-types Sub-types →
- Benign neoplasm of meninges 0 trials · 5 incl. sub-types Sub-types →
- Central nervous system hemangioma 0 trials · 2 incl. sub-types Sub-types →
- Multinodular and vacuolating neuronal tumor 2 trials
- Diffuse leptomeningeal glioneuronal tumor 1 trial
- Polymorphous low grade neuroepithelial tumor of the young 1 trial
- Benign neoplasm of peripheral nervous system 0 trials Sub-types →
- Benign neoplasm of spinal cord 0 trials Sub-types →
- Central nervous system chondroma 0 trials
- Central nervous system leiomyoma 0 trials
- Central nervous system lipoma 0 trials Sub-types →
- Myxoid glioneuronal tumor 0 trials
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Central nervous system germ cell tumor 6 trials · 9 incl. sub-types
6 sub-types
- Central nervous system germinoma 2 trials · 4 incl. sub-types Sub-types →
- Malignant pineal area germ cell neoplasm 2 trials · 3 incl. sub-types Sub-types →
- Central nervous system nongerminomatous germ cell tumor 2 trials Sub-types →
- Childhood central nervous system germ cell tumor 0 trials · 2 incl. sub-types Sub-types →
- Adult central nervous system germ cell tumor 0 trials Sub-types →
- Mixed germ cell tumor of central nervous system 0 trials Sub-types →
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Epidural abscess 5 trials
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Optic nerve neoplasm 1 trial · 4 incl. sub-types
3 sub-types
- Optic nerve glioma 2 trials · 3 incl. sub-types Sub-types →
- Optic nerve sheath meningioma 1 trial
- Bilateral meningioma of optic nerve 0 trials
Most studied deeper sub-types
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New hope for kids with tough cancers: targeted radiation trial launches
Disease control Recruiting nowThis early-stage trial tests a radioactive drug (Lu-177 edotreotide) in children aged 2 to 17 with cancers that have a specific marker (SSTR-positive). The goal is to find the right dose and check safety. About 20 children whose cancer has returned or not responded to prior treat…
Phase 1 • Sponsor: ITM Solucin GmbH • Aim: Disease control
Last updated Sep 19, 2026 00:00 UTC
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Experimental combo targets Hard-to-Treat brain cancers
Disease control Recruiting nowThis study tests two drugs—tarlatamab and temozolomide—in adolescents and adults with high-grade brain tumors that have a specific marker called DLL3. The goal is to see if the combination is safe and can shrink tumors. About 70 participants will be enrolled across multiple cente…
Phase 1/2 • Sponsor: Centre Leon Berard • Aim: Disease control
Last updated Sep 16, 2026 00:00 UTC
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Promising combo therapy offers hope for kids with hard-to-treat brain cancers
Disease control Recruiting nowThis study tests a combination of drugs given in low, frequent doses to slow or stop the growth of recurrent brain tumors in children. The goal is to extend survival while maintaining quality of life. About 232 children with medulloblastoma, ependymoma, ATRT, or other rare CNS tu…
Phase 2 • Sponsor: Medical University of Vienna • Aim: Disease control
Last updated Sep 12, 2026 00:00 UTC
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New hope for breast cancer patients with brain tumors: drug combo trial underway
Disease control Recruiting nowThis study tests a combination of two drugs, elacestrant and abemaciclib, in people with a specific type of breast cancer (ER-positive, HER2-negative) that has spread to the brain. The goal is to see if the combination can shrink or control brain tumors. The trial involves about …
Phase 1/2 • Sponsor: Stemline Therapeutics, Inc. • Aim: Disease control
Last updated Sep 11, 2026 00:00 UTC
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New hope for kids with rare cancers: targeted drug repotrectinib enters trial
Disease control Recruiting nowThis study tests a drug called repotrectinib in children and young adults (up to age 25) with advanced solid tumors, lymphoma, or brain tumors that have specific gene changes (ALK, ROS1, or NTRK1-3). The goal is to find the safest dose and see if the drug shrinks tumors. Particip…
Phase 1/2 • Sponsor: Turning Point Therapeutics, Inc. • Aim: Disease control
Last updated Sep 06, 2026 00:00 UTC
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Killer virus turned against childhood brain cancer
Disease control Recruiting nowThis early-stage trial tests whether a specially engineered herpes virus (G207) is safe to inject directly into the brain tumors of children whose cancer has returned. Up to 24 children aged 3 to 21 will receive the virus, and some will also get a small dose of radiation to help …
Phase 1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Sep 06, 2026 00:00 UTC
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Immune cells engineered to fight brain cancer in kids
Disease control Recruiting nowThis early-phase study tests the safety of a new cell therapy called B7-H3 CAR T cells for children and young adults whose brain tumors have come back or are growing despite standard treatment. The therapy uses the patient's own immune cells, modified to target a protein (B7-H3) …
Phase 1 • Sponsor: Robbie Majzner • Aim: Disease control
Last updated Sep 05, 2026 00:00 UTC
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New drug trial offers hope for brain tumor patients
Disease control Recruiting nowThis study tests a drug called mirdametinib for people with certain brain or spinal cord tumors (gliomas). The goal is to see if it is safe and can shrink tumors or improve symptoms. About 26 adults will take part, and the drug targets tumors with specific genetic changes.
Phase 1/2 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Disease control
Last updated Sep 05, 2026 00:00 UTC
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New drug PLX038 targets aggressive brain tumors
Disease control Recruiting nowThis study tests a drug called PLX038 in adults with brain or spinal cord tumors, including those with changes in the MYC or MYCN genes. The trial has two phases: first, finding the right dose, then checking if it works. Participants receive PLX038 intravenously every three weeks…
Phase 1/2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Aug 14, 2026 00:00 UTC
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New immune drug PHST001 enters first human trials for Hard-to-Treat cancers
Disease control Recruiting nowThis early-phase trial is testing a new drug called PHST001, which helps the immune system attack cancer cells by blocking a protein called CD24. The study will first test PHST001 alone, then in combination with standard chemotherapy, in adults with advanced solid tumors (includi…
Phase 1 • Sponsor: Pheast Therapeutics • Aim: Disease control
Last updated Aug 14, 2026 00:00 UTC
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Engineered immune cells target deadly brain tumors in children
Disease control Recruiting nowThis study tests a new treatment called BCB-276 for children and young adults with diffuse intrinsic pontine glioma (DIPG), a rare and aggressive brain tumor. BCB-276 is made from a patient's own immune cells, which are modified in a lab to recognize and attack the cancer. The tr…
Phase 2 • Sponsor: BrainChild Bio, Inc • Aim: Disease control
Last updated Aug 06, 2026 00:00 UTC
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New hope for kids with deadly brain cancer? drug ONC206 enters human trials
Disease control Recruiting nowThis early-phase trial tests a new drug called ONC206 in children and young adults with diffuse midline glioma or other recurrent brain tumors. The drug aims to kill cancer cells by causing stress in them, without harming healthy cells. Researchers are looking for the safest dose…
Phase 1 • Sponsor: Sabine Mueller, MD, PhD • Aim: Disease control
Last updated Jun 27, 2026 13:07 UTC
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New hope for toddlers with rare brain tumors: targeted drug entrectinib tested
Disease control Recruiting nowThis study tests the drug entrectinib in children under 3 with certain brain tumors (NTRK or ROS1 gene fusions). The goal is to see if the drug can shrink tumors and delay the need for chemotherapy. About 52 children will take entrectinib by mouth, and doctors will monitor tumor …
Phase 2 • Sponsor: St. Jude Children's Research Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:32 UTC
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New pill shows promise in early brain tumor trial
Disease control Recruiting nowThis early-stage study tests an oral drug called ONC206 in adults with brain tumors that have come back. The main goal is to find the safest dose and check for side effects. About 102 participants will take the drug once or several times a week.
Phase 1 • Sponsor: Jazz Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC
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Double contrast MRI could sharpen brain diagnosis
Diagnosis Recruiting nowThis study tests whether using two contrast agents (gadolinium and ferumoxytol) in one MRI session can improve the detection and diagnosis of brain and central nervous system abnormalities. About 150 participants with neurological symptoms or known brain lesions will undergo imag…
Phase 2 • Sponsor: OHSU Knight Cancer Institute • Aim: Diagnosis
Last updated Sep 16, 2026 00:00 UTC
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New imaging tool helps doctors see brain tumors more clearly
Diagnosis Expanded accessThis program offers a special PET scan using a radioactive tracer called methionine to help doctors better see and manage central nervous system (brain, spine) and head/neck tumors in children and young adults. The scan provides extra information that can guide treatment decision…
Sponsor: St. Jude Children's Research Hospital • Aim: Diagnosis
Last updated Jun 27, 2026 12:23 UTC
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New brain scan could spot tumors missed by standard MRI
Diagnosis Recruiting nowThis study tests whether a special PET/MRI scan using a radioactive tracer called Ga68-DOTATATE can better detect certain brain tumors (like meningioma) and tell them apart from changes caused by past treatments. About 200 adults with these tumors will get the scan alongside stan…
Phase 4 • Sponsor: Weill Medical College of Cornell University • Aim: Diagnosis
Last updated Jun 27, 2026 07:59 UTC
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SmartMatch: could a lab test find the right drug for your brain tumor?
Knowledge-focused Recruiting nowThis study is testing a new technology called SmartMatch that analyzes tumor tissue from people with recurrent brain or spinal cord tumors. The goal is to see if SmartMatch can quickly identify which drugs might work best for each person's specific tumor. About 80 participants ag…
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Sep 17, 2026 00:00 UTC
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Brain cancer patients rate telemedicine care in new study
Knowledge-focused Recruiting nowThis study asks brain cancer patients about their experience with telemedicine compared to in-person visits. Researchers want to learn if patients feel they receive good care through virtual appointments. The goal is to improve how care is delivered to people with brain tumors.
Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Sep 16, 2026 00:00 UTC
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Scientists launch massive tumor repository to unlock cancer secrets
Knowledge-focused Recruiting nowThis study collects extra blood, urine, and tumor samples from children and adults with certain cancers to build a large tissue repository. Researchers will analyze these samples to learn more about the genetic and molecular makeup of these tumors. The goal is to support future s…
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Sep 06, 2026 00:00 UTC
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Massive childhood cancer registry launches to unlock better treatments
Knowledge-focused Recruiting nowThis study is a large registry that collects health information and leftover tumor or blood samples from up to 75,000 children and young adults with cancer. The goal is to track outcomes and gather data to help doctors find better ways to treat and care for these patients over ti…
Sponsor: Children's Oncology Group • Aim: Knowledge-focused
Last updated Aug 27, 2026 00:00 UTC
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Massive data collection launched for brain surgery patients
Knowledge-focused Recruiting nowThis study is gathering medical information and samples from up to 5,000 people with neurosurgical conditions like brain tumors, epilepsy, and Parkinson's disease. Participants receive standard care while their data is collected for future research. No new treatments are being te…
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) • Aim: Knowledge-focused
Last updated Aug 20, 2026 00:00 UTC
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Genetic blueprint of tumors may guide smarter cancer treatment
Knowledge-focused Recruiting nowThis study looks at whether detailed genetic testing of tumor tissue or blood can help doctors make better treatment decisions for people with advanced solid tumors or primary brain cancers. About 550 participants will have their tumors genetically profiled, and a smaller group w…
Sponsor: The Belgian Society of Medical Oncology • Aim: Knowledge-focused
Last updated Jul 22, 2026 00:00 UTC
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Gut bacteria linked to cancer survivor symptoms?
Knowledge-focused Recruiting nowThis study follows 600 childhood cancer survivors aged 8-18 to understand why symptoms like fatigue, pain, and depression often occur together. Researchers will use questionnaires and stool samples to see if gut bacteria and their byproducts play a role. The goal is to find bette…
Sponsor: The Children's Hospital of Zhejiang University School of Medicine • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:02 UTC
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Brain tumor clues in spinal fluid: mayo clinic launches major biomarker hunt
Knowledge-focused Recruiting nowThis study collects cerebrospinal fluid (CSF) from 400 adults with brain or spinal cord tumors to identify biomarkers—measurable signs of disease. Researchers hope these samples will help develop new strategies to diagnose, monitor, and treat brain tumors more effectively. Partic…
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Could a smartphone app replace neurologist visits for brain tumor patients?
Knowledge-focused Recruiting nowThis study is testing whether a mobile app called 'Iskhaa' can help brain tumor patients perform their own neurological exams at home. Six hundred participants will use the app to record videos of tasks like speaking and walking, which an AI will analyze. The goal is to see if th…
Sponsor: Tata Memorial Centre • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:07 UTC