Anaphylaxis
MONDO:0100053An acute hypersensitivity reaction that occurs from exposure to an allergen. It results from the release of histamine and histamine-like substances from mast cells, and can present with breathing difficulty due to narrowed airways, dizziness and hypotension, skin rash, weak pulse, nausea and vomiting.
Also known as: anaphylactic shock, systemic anaphylaxis
31 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsSub-types
Broader categories
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HPV vaccine shows promise for girls on Immune-Suppressing drugs
⭐️ VACCINE ⭐️ CompletedThis study looked at whether the HPV vaccine works in girls aged 9 to 17 who are taking medicines that weaken their immune system, such as after an organ transplant or for diseases like lupus. The goal was to see if their bodies produce enough antibodies to protect against HPV. T…
Phase: PHASE2 • Sponsor: University Hospital, Bordeaux • Aim: ⭐️ VACCINE ⭐️
Last updated Jun 27, 2026 12:36 UTC
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Milk allergy treatment shows promise in Long-Term quality of life study
Disease control CompletedThis study followed 250 children who received oral immunotherapy (OIT) for severe milk allergy to see how well it works over time. Researchers measured how much milk participants could drink and how their quality of life improved. The goal is to understand the long-term benefits …
Phase: NA • Sponsor: Helsinki University Central Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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Fiber fix for peanut allergy? small study tests prebiotic boost to OIT
Disease control CompletedThis small pilot study tested whether adding a prebiotic fiber (a type of plant fiber found in grocery stores) to peanut oral immunotherapy could help children aged 4 to 17 with peanut allergy tolerate more peanut protein with fewer side effects. Twenty children participated, and…
Phase: PHASE1, PHASE2 • Sponsor: University of Chicago • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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Full-Dose drug testing could pinpoint surgery allergies
Diagnosis CompletedThis study tested whether giving full therapeutic doses of anaesthetics like propofol and ketamine can safely diagnose drug allergies in people who had a suspected allergic reaction during surgery. Fifty adult patients with a history of perioperative hypersensitivity underwent in…
Phase: NA • Sponsor: University Hospital, Antwerp • Aim: Diagnosis
Last updated Jun 26, 2026 15:03 UTC
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Scientists track severe allergies to uncover hidden patterns
Knowledge-focused CompletedThis completed study followed 945 people, mostly children and young adults with severe eczema or related allergic conditions, along with their relatives. Researchers observed how these diseases progress over up to a year, using tests like allergy skin pricks, blood draws, and lun…
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Jul 04, 2026 00:00 UTC
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Are allergy pens long enough? study measures thigh depth to find out
Knowledge-focused CompletedThis study looked at 107 people with severe food or insect allergies to measure the distance from skin to muscle in their thighs. The goal was to see if the needles on common epinephrine auto-injectors (like EpiPen) are long enough to deliver the medicine into the muscle, as reco…
Phase: NA • Sponsor: Centre Hospitalier Régional Metz-Thionville • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:02 UTC
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New Under-the-Tongue allergy shot could replace needles
Knowledge-focused CompletedThis study tested a new drug called l-dipivefrin (IN-001) given under the tongue as a spray or drops, compared to standard epinephrine injections, in 32 healthy adults. The goal was to see how the body absorbs the drug and its safety. It is an early-stage study to gather informat…
Phase: PHASE1 • Sponsor: Insignis Therapeutics, Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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New study aims to spot Life-Threatening allergies in the operating room
Knowledge-focused CompletedThis study looked at 145 people who had an allergic or non-allergic reaction during surgery. Researchers wanted to find out which signs, like skin changes or heart rate, could tell the difference between a true allergy and a non-allergic reaction. The goal is to help doctors trea…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:04 UTC
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French study tracks accidental nut allergy reactions in kids
Knowledge-focused CompletedThis completed study looked at 147 French children with confirmed peanut or tree nut allergies to see how often they accidentally have allergic reactions in everyday life. Researchers also recorded how severe those reactions were and what factors might increase risk. The goal is …
Sponsor: University Hospital, Lille • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC
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Scientists gather clues on mysterious immune defects
Knowledge-focused CompletedThis study collected blood, saliva, stool, urine, and skin samples from 19 people with unknown or poorly understood immune system problems. The goal was to learn how different parts of the immune system work together. No treatments or drugs were tested. Participants were followed…
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC
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New study aims to pinpoint safe observation time for kids after anaphylaxis
Knowledge-focused CompletedThis study looked back at the medical records of 67 children treated for anaphylaxis in a Turkish emergency department over 10 years. Researchers wanted to know how long kids were observed and how often a second wave of symptoms (biphasic reaction) occurred. They also looked for …
Sponsor: Aydin Adnan Menderes University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC