Anaphylaxis

This study tests a new injection called UKK-0018 for people with peanut allergies. The goal is to train the immune system to handle peanut exposure without a severe reaction. The trial involves 40 adults aged 18-55 and will first check safety, then see if it helps increase the am…

This study compares two ways of giving oral immunotherapy to children aged 6–16 with milk or egg allergy. One method uses daily increasing doses over a week ('rush'), while the other uses doses every two weeks ('conventional'). The goal is to see which is safer and more effective…

This study looks for better ways to diagnose allergies to cephalosporin antibiotics, which are commonly used but can cause serious reactions. Researchers will test 300 adults with a history of possible allergic reactions using skin tests and controlled drug challenges. The goal i…

This study tests if inhaled epinephrine can quickly ease systemic allergic reactions that happen during allergy testing or treatment. About 100 people aged 12 and older with known allergies will take part. The goal is to see how fast symptoms improve, aiming for a safer and easie…

This study looks at the safety of a nasal spray called neffy compared to a standard epinephrine shot for treating allergic reactions. It involves 600 people aged 4 and older who have an allergic reaction during a food challenge or allergy shot session. The goal is to see if the s…

This study looks at whether giving steroids along with antihistamines helps children recover faster from allergic reactions to food. About 160 children with food allergies will participate during a scheduled food challenge at the clinic. Half will receive antihistamines alone, an…

This study looks at severe allergic reactions that can happen during surgery. Researchers want to better diagnose these reactions and find out what causes them, so they can prevent future episodes. About 115 people who have had a suspected allergic reaction in the operating room …

This study aims to find the genetic causes behind certain allergic and immune system disorders. Researchers will collect blood, saliva, and tissue samples from up to 10,000 people of all ages, along with some family members. No treatments are given; the goal is simply to learn mo…

This study looks at different forms of IgE (a protein involved in allergic reactions) in healthy volunteers and people with conditions like severe allergies, chronic hives, mastocytosis, and immune deficiencies. Researchers aim to understand how these IgE variations relate to hea…