Anaphylaxis
MONDO:0100053An acute hypersensitivity reaction that occurs from exposure to an allergen. It results from the release of histamine and histamine-like substances from mast cells, and can present with breathing difficulty due to narrowed airways, dizziness and hypotension, skin rash, weak pulse, nausea and vomiting.
Also known as: anaphylactic shock, systemic anaphylaxis
31 clinical trials for this condition and its sub-types.
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Broader categories
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Peanut allergy vaccine? new peptide therapy aims to protect kids
Disease control OngoingThis phase 2 trial tests a new treatment called PVX108 for children and teens with peanut allergy. The treatment uses small pieces of peanut protein to help the immune system become less reactive. About 90 participants will receive either PVX108 or a placebo, and researchers will…
Phase: PHASE2 • Sponsor: Aravax Pty Ltd • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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Needle-free allergy rescue: nasal spray could replace EpiPen
Symptom relief ENROLLING_BY_INVITATIONThis study tests a new epinephrine nasal powder (FMXIN002) against the standard EpiPen injection in 50 healthy adults with allergies. Researchers will measure how quickly and effectively the nasal spray delivers epinephrine into the body and its effects on vital signs. The goal i…
Phase: PHASE1, PHASE2 • Sponsor: Nasus Pharma • Aim: Symptom relief
Last updated Jun 27, 2026 07:57 UTC
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Scientists dig into the mystery of unexplained allergic shock
Knowledge-focused OngoingThis study looks at people who have severe allergic reactions (anaphylaxis), especially when the cause is unknown. Researchers will do blood tests and bone marrow biopsies to find genetic or molecular clues. The goal is to understand what goes wrong in the body, not to test a new…
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Jul 04, 2026 00:00 UTC
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VR training could match High-Tech mannequins for emergency drills
Knowledge-focused OngoingThis study tests whether virtual reality (VR) can train new doctors as well as high-fidelity mannequins for handling emergencies like severe allergic reactions and low oxygen levels. 124 medical interns will be randomly assigned to either VR or mannequin training, then tested on …
Phase: NA • Sponsor: Seoul National University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:34 UTC