ACTH-dependent Cushing syndrome
MONDO:0020528A group of endogenous Cushing syndrome caused by abnormal production of ACTH due to pituitary adenoma or an extrapituitary tumor.
Also known as: ACTH-dependent CS, adrenocorticotropic hormone-dependent Cushing syndrome, corticotropin-dependent Cushing syndrome, pituitary-dependent Cushing's disease, ACTH hypersecretion, pituitary, adrenocorticotropic hormone, inappropriate secretion, pituitary Cushing disease, pituitary Cushing diseases
28 clinical trials for this condition and its sub-types.
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Broader categories
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New hope for rare hormone disorder: drug targets Out-of-Control cortisol
Disease control Recruiting nowThis study tests a new drug called Lu AG13909 in 18 adults with Cushing's disease, a rare condition where the body produces too much cortisol. The goal is to see if the drug can safely lower cortisol levels to normal. Participants will receive the drug through an IV or injection,…
Phase 2 • Sponsor: H. Lundbeck A/S • Aim: Disease control
Last updated Aug 23, 2026 00:00 UTC
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Could a Dual-Action pill tame the tumor behind cushing disease?
Disease control Recruiting nowThis phase 2 trial tests fimepinostat, a drug that blocks two cancer-related pathways, in adults with Cushing disease caused by a pituitary tumor. The goal is to see if the drug can lower cortisol levels to normal within four weeks. The study compares two doses and includes patie…
Phase 2 • Sponsor: University of California, Los Angeles • Aim: Disease control
Last updated Jul 19, 2026 00:00 UTC
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Could a cancer drug tame cushing disease?
Disease control Recruiting nowThis phase 2 trial tests seliciclib, an oral drug, in 13 adults with Cushing disease. The goal is to see if 4 weeks of treatment can lower high cortisol levels to normal or reduce them by at least half. Researchers will also monitor safety and check for changes in tumor size and …
Phase 2 • Sponsor: Cedars-Sinai Medical Center • Aim: Disease control
Last updated Jun 26, 2026 16:20 UTC
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Can a simple blood test catch Cushing's earlier?
Diagnosis Recruiting nowThis study aims to improve how doctors diagnose Cushing's syndrome, a condition caused by too much cortisol. Researchers will test the accuracy of the desmopressin stimulation test in 140 people aged 18-70 who have or may have Cushing's, plus healthy volunteers. Participants will…
Phase 2 • Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) • Aim: Diagnosis
Last updated Sep 02, 2026 00:00 UTC
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New PET scans could unmask hidden tumors in rare hormone disorder
Diagnosis Recruiting nowThis study compares advanced PET scans (68Ga-DOTATATE and F-DOPA) with standard imaging to locate hidden tumors causing ectopic Cushing syndrome. About 80 adults with this condition will undergo multiple scans over time. The goal is to see which scan or combination best finds the…
Phase 2 • Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) • Aim: Diagnosis
Last updated Jul 10, 2026 00:00 UTC
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New scan could pinpoint hidden brain tumors in cushing patients
Diagnosis Recruiting nowThis study tests whether a special PET scan (FET PET/CT) can better locate small pituitary tumors that cause Cushing disease. About 50 adults with confirmed Cushing disease who are scheduled for pituitary surgery will receive the scan before their operation. The goal is to see if…
Early phase 1 • Sponsor: Mayo Clinic • Aim: Diagnosis
Last updated Jun 27, 2026 14:01 UTC
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New scan could spot 'Invisible' brain tumors in Cushing's patients
Diagnosis Recruiting nowThis study tests whether a special PET scan, combined with a drug called desmopressin, can find tiny pituitary tumors that standard MRI scans miss in people with Cushing's disease. About 22 participants will receive the drug and a radioactive tracer, then undergo imaging. The goa…
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) • Aim: Diagnosis
Last updated Jun 27, 2026 12:05 UTC
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New PET scan could spot tiny brain tumors missed by MRI
Diagnosis Recruiting nowThis study is testing whether a special PET scan using [18F]FET can better locate small pituitary tumors that cause Cushing's disease. Standard MRI misses these tumors in up to 30% of cases. Researchers will compare PET results with MRI and surgical findings in 20 adults to see i…
Sponsor: Hospices Civils de Lyon • Aim: Diagnosis
Last updated Jun 27, 2026 11:00 UTC
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New PET scan aims to spot tiny brain tumors that standard MRI misses
Diagnosis Recruiting nowThis early study tests a special PET/MRI scan using a radioactive tracer called FET to find small pituitary tumors that don't show up on regular MRI. The goal is to improve detection of these hormone-producing tumors in 5 adults with confirmed biochemical disease. If the scan wor…
Phase 1 • Sponsor: Mayo Clinic • Aim: Diagnosis
Last updated Jun 27, 2026 11:00 UTC
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New ultrasound technique could help surgeons spot hidden pituitary tumors
Diagnosis Recruiting nowThis study tests a new ultrasound method to help surgeons find pituitary tumors during surgery. Researchers will compare ultrasound images with MRI scans to see if the new technique can better identify tumors in people with Cushing's disease and other pituitary tumors. About 110 …
Sponsor: Mayo Clinic • Aim: Diagnosis
Last updated Jun 27, 2026 08:10 UTC
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Headband may ease withdrawal after cushing surgery
Symptom relief Recruiting nowThis study looks at how people recover from Cushing syndrome after surgery. Researchers want to understand what affects recovery and whether using a MUSE biofeedback headband can help ease withdrawal symptoms. The study will include 700 adults who are planning to have curative su…
Sponsor: Mayo Clinic • Aim: Symptom relief
Last updated Jun 26, 2026 12:36 UTC
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Scientists hunt for genetic clues behind childhood pituitary tumors
Knowledge-focused Recruiting nowThis study aims to uncover the genetic causes of pituitary and hypothalamic tumors in children. Researchers will collect blood and tumor samples from up to 2,000 participants to analyze DNA and look for inherited patterns. The study also trains doctors and tests new MRI technique…
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) • Aim: Knowledge-focused
Last updated Sep 10, 2026 00:00 UTC
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Cured of cushing as a kid? scientists want to track your health for years
Knowledge-focused Recruiting nowThis study looks at the long-term health of people who were cured of Cushing disease before age 21. Researchers want to understand how past high cortisol levels affect the body and mind years later. Participants will complete surveys and have check-ups every 5 years. The goal is …
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) • Aim: Knowledge-focused
Last updated Sep 03, 2026 00:00 UTC
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New imaging tracer could shed light on adrenal cholesterol
Knowledge-focused Recruiting nowThis study tests a special radioactive tracer called [18F]FNP-59 to see if it can safely and clearly show cholesterol activity in the adrenal gland using PET scans. About 24 people will take part, including healthy volunteers and those with known adrenal problems. The goal is to …
Early phase 1 • Sponsor: Benjamin Viglianti • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:02 UTC
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Cushing's patients wanted for Long-Term health tracking study
Knowledge-focused Recruiting nowThis study is not testing a new treatment. Instead, it follows 300 people aged 14 and older with Cushing's syndrome to collect data on their health before and after standard treatments like surgery, medication, or radiation. The goal is to build a registry that helps doctors unde…
Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:55 UTC