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127005 trials found · Page 5538 of 6351
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Drug aimed at fixing bone marrow after transplant falls short in early study
Disease control Stopped earlyPoor graft function (PGF) after allogeneic hematopoietic cell transplantation (allo-HCT) is a misunderstood complication associated with poor outcome and limited therapeutic options. Despite the lack of standardized diagnostic criteria, PGF is commonly defined as follows: one or …
Phase 2 • Sponsor: University Hospital, Lille • Aim: Disease control
Last updated Jun 27, 2026 07:52 UTC
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Blood filter shows promise for autoimmune patients
Disease control CompletedDocumentation of the safety and effectiveness profile of the CE-labelled immunoadsorber GLOBAFFIN® in clinical routine according to their intended use.
Sponsor: Fresenius Medical Care Deutschland GmbH • Aim: Disease control
Last updated Jun 26, 2026 14:18 UTC
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Blood test may predict heart attack risk during surgery
Knowledge-focused Recruiting nowThe team is investigating whether N-terminal pro B-type natriuretic peptide (NT-proBNP) and other cardiac markers are useful for predicting outcomes for patients undergoing vascular surgery. By measuring NT-proBNP before and after surgery, the investigators may be able to determi…
Sponsor: Norfolk and Norwich University Hospitals NHS Foundation Trust • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:05 UTC
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Experimental drug K0706 tested for lewy body dementia
Symptom relief Stopped earlyThis study evaluates the safety and tolerability of treatment with K0706 in Dementia with Lewy Bodies (DLB). The hypothesis is that K0706 will be safe and tolerable and that this drug will alter CSF and plasma biomarkers in DLB. Clinical assessments of cognitive, behavioral and …
Phase 2 • Sponsor: Georgetown University • Aim: Symptom relief
Last updated Jun 27, 2026 13:05 UTC
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New MRI scans aim to unlock secrets of lung disease and long COVID
Knowledge-focused PausedLung magnetic resonance imaging (MRI) with proton and inhaled inert gases has demonstrated a clinical ability to provide valuable structural and functional information in lung disease. Advances in lung MRI methods have led to the STH department handling clinical imaging referrals…
Sponsor: Sheffield Teaching Hospitals NHS Foundation Trust • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Bone cement safety confirmed in Real-World spine surgery study
Disease control Recruiting nowA Post-Market Clinical Follow-Up (PMCF) Study to collect clinical data on safety and performance of all TEKNIMED Spine range of products: SPINEFIX, HIGH V+, OPACITY+ and F20 bone cements and mixing and injection systems, and all their private labels. TEKNIMED bone cements are le…
Sponsor: Teknimed • Aim: Disease control
Last updated Jun 26, 2026 14:39 UTC
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Cancer drug trial stopped early: only 5 patients enrolled
Disease control Stopped earlyA non randomized, unblinded, open label phase 2 study to investigate the efficacy of pembrolizumab in patients with relapsed/refractory diffuse large B cell lymphoma (DLBCL) with PD-L1 genetic alterations
Phase 2 • Sponsor: University of Chicago • Aim: Disease control
Last updated Jun 27, 2026 09:07 UTC
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Surgeons watch their own surgeries to get better
Knowledge-focused CompletedRecent studies demonstrate the critical role of individual surgeon performance, including both the approach they take to an operation as well as their technical skill, in determining patient outcomes. Utilizing the rich data collected by the Abdominal Core Health Quality Collabor…
Sponsor: University of North Carolina, Chapel Hill • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC
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Tiny particles in blood may help detect hidden cancer spread
Knowledge-focused CompletedPeritoneal carcinomatosis (PC), a tumoral tumor of the peritoneum, is a frequent metastatic localization of colorectal cancer (CRC, 13%). Long regarded as a palliative situation, its management has progressed significantly with a curative treatment based on a complete cytoreducti…
Sponsor: Assistance Publique Hopitaux De Marseille • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC
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New study tracks neck surgery success with spacers
Knowledge-focused Recruiting nowThis is a prospective study to assess fusion rates and cervical sagittal parameters following posterior cervical arthrodesis procedures supplemented with CIS. Data will be collected from medical records for up to 730 days after surgery. Data to be collected will be demographic, p…
Sponsor: Ohio State University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC
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Could a brief nerve squeeze improve lung surgery recovery?
Knowledge-focused CompletedThis prospective clinical study aimed to evaluate the postoperative effects of temporary phrenic nerve paralysis induced by intraoperative phrenic nerve crush during lung resection surgery. The study compared postoperative pulmonary function, diaphragm activity, and clinical outc…
Sponsor: Ferdane Melike Duran • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:00 UTC
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Lung and sleep disorder study seeks clues for better diagnosis
Knowledge-focused Recruiting nowClinically, all patients with interstitial lung disease(ILD) were observed, and relevant clinical data were collected. Bronchoscopic specimens were collected according to the condition of the enrolled patients, and the rapid on site evaluation(ROSE) was evaluated, combined with t…
Sponsor: Dan Liu • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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Tiny nerve zap study probes migraine pain mystery
Knowledge-focused CompletedThe primary aim of this study is to assess the reversibility of a range of psychophysical markers of pain processing in patients with chronic migraine or cluster headache before and after ONS insertion and comparing to patients having a general anaesthetic (GA) for a non-painful …
Sponsor: Barts & The London NHS Trust • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC
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New implant method may offer better fit for lower dentures
Disease control OngoingH0: "Within the first year post-placement, four interforaminally placed, immediately loaded 2.4 mm narrow-diameter one-piece TiZr implants with miniaturized stud-type attachments show improved patient-reported outcome measures (PROMS) compared to two interforaminally placed, earl…
Sponsor: University of Bern • Aim: Disease control
Last updated Jun 27, 2026 09:05 UTC
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Scientists map nerve signals to improve gastric stimulation for stomach paralysis
Knowledge-focused OngoingThis study aims to characterize how vagus nerve compound action potentials (CNAPs) conduct along the vagus nerve in gastroparetic patients receiving GES therapy using a flexible, non-invasive multielectrode array (MEA).
Sponsor: Indiana University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC
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Can a simple pill combo soften radiation scars? new trial explores.
Symptom relief CompletedObjectives: This is a feasibility study in preparation for the main multicentre randomised trial, which is anticipated to have two arms: * Arm A: the current best standard of care \[rehabilitation exercises\] * Arm B: the current best standard of care \[rehabilitation exercises…
Phase 1 • Sponsor: University College, London • Aim: Symptom relief
Last updated Jun 27, 2026 09:09 UTC
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ICU superbug study reveals resistance patterns
Knowledge-focused CompletedIn this study, we first aimed to reveal the resistance profile of Enterobacteriales bloodstream infections at our center. We evaluated data from patients with ESBL, colistin, and carbapenem resistance and identified resistance risk factors. We then reviewed our approach to mana…
Sponsor: Ankara City Hospital Bilkent • Aim: Knowledge-focused
Last updated Jun 26, 2026 17:19 UTC
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New exercise approach may boost fitness and balance in stroke survivors
Symptom relief Stopped earlyPeople with stroke should exercise to maintain function and reduce the risk of another stroke. Different types of exercise target different components of fitness, such as aerobic, strength, and balance. Post-stroke exercise guidelines exist for each type of exercise separately (e…
Sponsor: Toronto Rehabilitation Institute • Aim: Symptom relief
Last updated Jun 26, 2026 15:24 UTC
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Hidden clues in gut tissue may predict ulcerative colitis Flare-Ups
Knowledge-focused CompletedThis retrospective study examines patients with ulcerative colitis who initiated advanced therapy for their disease. In clinical practice, patients with only mild inflammation on endoscopy (Mayo Endoscopic Subscore 1, or MES1) often do not undergo treatment optimization or therap…
Sponsor: IRCCS San Raffaele • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC
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Study probes how kids, parents, and doctors recall the moment of cancer diagnosis
Knowledge-focused OngoingPresent project aims to investigate memories related to a cancer communication diagnosis in pediatric oncology. It evaluates possible common elements and specificity between family and healthcare staff.
Sponsor: Meyer Children's Hospital IRCCS • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC