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127005 trials found · Page 5356 of 6351
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New community program aims to improve diabetes care for vulnerable populations
Disease control CompletedTo improve diabetes self-management outcomes, patients with type 2 diabetes (n=150 - aged 13-84) recruited from St. Vincent Clinic (SVC) and Teen Health Center Inc., Clinics will be randomized using block randomization to receive standard of care or the integrated model. Patients…
Sponsor: The University of Texas Medical Branch, Galveston • Aim: Disease control
Last updated Jun 27, 2026 08:11 UTC
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Progesterone levels key to IVF success in frozen embryo transfers
Knowledge-focused CompletedDuring an In Vitro Fertilization (IVF) attempt, several embryos are obtained but not all of them can be transferred to the uterus in the same cycle due to the risk of multiple pregnancies. Thus, it is very common for these couples to benefit from cryopreservation. Patients schedu…
Sponsor: University Hospital, Toulouse • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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One-Patient trial tests keytruda for rare ovarian cancer
Disease control CompletedThis is a study of pembrolizumab as consolidation therapy for a patient with small cell carcinoma of the ovary, hypercalcemic type (SCCOHT).
Sponsor: University Health Network, Toronto • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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Exercise may boost blood vessel function in mental health disorders
Knowledge-focused Recruiting nowThe purpose of this research study is to examine the effect of various forms of exercise training on blood vessel function in healthy individuals as well as individuals with mental health disorders (posttraumatic stress disorder (PTSD) and/or generalized anxiety disorder (GAD)).
Sponsor: Virginia Commonwealth University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC
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Vibrating away chemo pain: simple hand device tested in new study
Symptom relief Recruiting nowThe purpose of this pilot study is to determine the safety and feasibility of a daily 3-minute hand-held vibration therapy intervention to reduce the severity of CIPN in the hands. The investigators hypothesize that daily vibration therapy can reduce the severity of patient's CIP…
Sponsor: Indiana University • Aim: Symptom relief
Last updated Jun 27, 2026 12:39 UTC
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Can changing dialysis times save Patients' legs?
Knowledge-focused Completed* Peripheral Arterial Disease (PAD) is a common condition in patients with End-Stage Renal Failure (ESRF) undergoing dialysis. * Late diagnosis of PAD and hypoperfusion induced by dialysis sessions explain the high morbidity and mortality associated with this condition in hemodia…
Sponsor: University Hospital, Rouen • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:03 UTC
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Tiny additive could cut risk in abdominal pain blocks
Knowledge-focused CompletedLocoregional anesthesia techniques are now widely recommended in perioperative multimodal analgesia protocols. The transverse abdominal plane block (TAP block), which consists of the injection of a local anesthetic in the vascular-nervous plane between the internal oblique muscle…
Sponsor: Centre Hospitalier Universitaire de Nice • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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Virtual reality goggles could make IV sticks less scary for kids
Symptom relief Stopped earlyMain objective : Evaluate the effect of using a virtual reality mask during the peripheral intravenous catheter insertion in a pediatric day hospital on the pain and anxiety in children from 6 to 11 years old. Hypothesis : Using virtual reality mask during the peripheral intra…
Sponsor: University Hospital, Clermont-Ferrand • Aim: Symptom relief
Last updated Jun 27, 2026 07:58 UTC
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Ultrasound may replace CT scans for guiding cancer surgery
Knowledge-focused CompletedIn this study we aim to develop an automatic artery and bone segmentation algorithm, which is required for future clinical implementation of US registration for surgical navigation. Various registration methods will be evaluated with the data of this study to obtain most optimal …
Sponsor: The Netherlands Cancer Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC
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Brain pacemaker that adapts to you: hope for rare Parkinson's-Like disease
Disease control CompletedPatients routinely undergo deep brain stimulation (DBS) for treatment of symptoms related to neurodegenerative conditions, most commonly Parkinson's disease. In the Investigator's experience, and published evidence shows, that stimulation has effects on the autonomic nervous syst…
Sponsor: University of Oxford • Aim: Disease control
Last updated Jun 27, 2026 07:57 UTC
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Virtual reality training could make spinal taps safer for patients
Knowledge-focused CompletedLumbar punctures (LP) are frequent invasive procedures that are anxiety-provoking for both the patient and the clinicans performing the procedure. LP is performed by many practitioners, whether they are emergency physicians, neurologists, neurosurgeons, internists or rheumatologi…
Sponsor: University Hospital, Strasbourg, France • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC
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Could a menopause drug combo cut breast cancer risk?
Disease control CompletedPilot study to test feasibility of 6 months of bazedoxifene (BZA) plus conjugated estrogens (CE) to modulate breast MRI parameters.
Early phase 1 • Sponsor: Carol Fabian, MD • Aim: Disease control
Last updated Jun 27, 2026 07:55 UTC
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Hair transplant healing boost? study tests antiseptic combo
Disease control CompletedThis randomized controlled clinical trial was designed to evaluate the effectiveness of combining 10% povidone-iodine with 125 mg rifampicin for preoperative scalp antisepsis in hair transplantation procedures. The study was conducted in a private hair transplantation clinic betw…
Sponsor: Elif Asena KANTARCI • Aim: Disease control
Last updated Jun 26, 2026 14:10 UTC
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New cell therapy aims to stop transplant complications in blood cancer patients
Disease control Stopped earlyThe protocol is a phase I open label study evaluating the safety and feasibility of peri-transplant infusion of freshly expanded interferon gamma primed MSCs in adult and pediatric patients undergoing HCT for acute leukemia and myelodysplastic syndrome (MDS).
Phase 1 • Sponsor: Edwin Horwitz • Aim: Disease control
Last updated Jun 27, 2026 09:04 UTC
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Heart surgery without opioids: a safer way?
Knowledge-focused CompletedSince the 90's the concept of morphine sparing and morphine free anaesthesia (OFA) has progressively developed in non-cardiac surgery. The principle is based on the fact that in a sleeping patient a sympathetic reaction marked by hemodynamic modifications does not translate into …
Sponsor: Centre Hospitalier Universitaire Dijon • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:03 UTC
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Skip the cast? new study tests immediate wrist movement after fracture surgery
Symptom relief OngoingThe aim of this study is to analyze total lenght of the sick leace and functional outcome (PRWE) at 2 months between 2 weeks casting and immediate mobilization following volar plating for a DRF.
Sponsor: Tampere University Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 09:05 UTC
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New study to explore how tic disorders differ between men and women
Knowledge-focused Recruiting nowThe purpose of this study is to develop the adult tic disorders registry in order to characterize the relationship between tic severity and tic-related impairment in women compared to men with tic disorders.
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 26, 2026 14:22 UTC
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Swallow a magnet: new capsule could spot stomach disorders
Diagnosis CompletedThis is a feasibility study to assess the utility of magnetically controlled capsule endoscopy in the evaluation of gastroparesis and functional dyspepsia
Sponsor: University of California, Los Angeles • Aim: Diagnosis
Last updated Jun 27, 2026 12:24 UTC
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Brain study explores thinking skills in young people with psychosis
Knowledge-focused CompletedThe purpose of this study is to examine state representation in individuals aged 15-45 who have been diagnosed with a psychotic illness, as well as young adults who do not have a psychiatric diagnosis. State Representation is our ability to process information about our surroundi…
Sponsor: University of Minnesota • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC
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Massive study compares four diabetes drugs for heart safety
Knowledge-focused CompletedWe will use the target trial framework for causal inference to conduct this observational retrospective cohort study that uses claims data of adults with type 2 diabetes (T2D) included in the de-identified datasets of OptumLabs Data Warehouse (OLDW) and Medicare fee-for-service. …
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC