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116076 trials found · Page 5213 of 5804
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Study probes whether common osteoporosis meds harm dental implants
Knowledge-focused CompletedThis observational study aims to evaluate the relationship between the use of oral anti-resorptive agents and the success rate of dental implants in patients. Medical records from patients who received dental implants between January 2011 and December 2024 at National Taiwan Univ…
Sponsor: National Taiwan University Hospital • Aim: Knowledge-focused
Last updated Jun 26, 2026 12:52 UTC
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Brain stimulation study probes Cerebellum's role in dystonia
Knowledge-focused CompletedPurpose \- Objective : Sensorimotor adaptation allows the modification of the motor command taking into account the errors detected during execution of prior movements. It involves a large cortico-subcortical network. Isolated lesions of this network do not systematically alter …
Phase: NA • Sponsor: Institut National de la Santé Et de la Recherche Médicale, France • Aim: Knowledge-focused
Last updated Jun 26, 2026 13:28 UTC
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Tiny study looks at hepatitis c Virus's hidden protein partners
Knowledge-focused CompletedThe emergence of hepatocellular carcinoma (HCC) has prompted a search for a thorough understanding of the biology of one of its major causative agents, the hepatitis C virus (HCV). HCV particles acquire via budding and encapsidation cellular proteins. There is mounting evidence o…
Phase: NA • Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 26, 2026 13:28 UTC
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300 patients monitored to uncover early signs of blood cancer
Knowledge-focused ENROLLING_BY_INVITATIONThe proposed minimal diagnostic criteria for myelodysplastic syndromes (MDS) and potential pre-MDS conditions has been released by an international consensus group. Based on the criteria, patients with persistent cytopenia could be diagnosed with MDS, CCUS and ICUS. However, the …
Sponsor: The First Affiliated Hospital of Soochow University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC
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New registry tracks young brain tumor patients to boost research
Knowledge-focused CompletedThe Register is based on the study HIT 2000 that recruited patients until 31.12.2011. All german patients with intracranial medulloblastoma, CNS-PNET, ependymoma can be included in the register. Object of the register is to maintain the quality of diagnostic standard by using of …
Sponsor: Universitätsklinikum Hamburg-Eppendorf • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC
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Blood test for humira levels could personalize arthritis care
Knowledge-focused CompletedAdalimumab is a fully human monoclonal antibody to tumor necrosis factor-alpha (TNF-α) approved in rheumatoid arthritis (RA) refractory to disease modifying anti rheumatic drugs (DMARDs) and for the treatment of severe, active and progressive RA in adults not previously treated w…
Phase: PHASE4 • Sponsor: University Hospital, Tours • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC
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Breathing in xenon: a new MRI method to map lung function
Knowledge-focused Recruiting nowThe purpose of this study is to develop and evaluate the usefulness of MRI using 129Xe gas for regional assessment of pulmonary function. Specifically, three forms of 129Xe MRI contrast will be the investigators focus - 1) imaging of the 129Xe ventilation distribution, 2) imaging…
Phase: PHASE2 • Sponsor: Bastiaan Driehuys • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC
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Massive DC study aims to improve HIV care for 19,000 people
Knowledge-focused Recruiting nowThe goal of the DC Cohort is to establish a clinic-based city-wide longitudinal cohort that will describe clinical outcomes, and improve the quality of care for patients diagnosed with Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) or at higher risk f…
Sponsor: George Washington University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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New female condom put to the test in 500-Woman study
Disease control CompletedWHAT IS THE FEMALE CONDOM? The female condom being examined in this study is investigational (experimental) and is not yet approved by the Food and Drug Administration (FDA). The female condom is made up of a pouch that adjusts to the shape of the vagina. The female condom that w…
Phase: NA • Sponsor: Premier Research • Aim: Disease control
Last updated Jun 27, 2026 09:03 UTC
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Massive 10-Year health check: what happens when chronic diseases collide?
Knowledge-focused ENROLLING_BY_INVITATIONThe Chinese Population Health and Multimorbidity Study (CPHMS; initially named China Pulmonary Health Study, CPHS) was a large-scale epidemiological survey designed to investigate the pulmonary health of Chinese adults aged 20 years or older leveraging a multistage stratified sam…
Sponsor: China-Japan Friendship Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:11 UTC
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Scientists hunt for genetic clues behind eye inflammation
Knowledge-focused Recruiting nowIn order to improve the investigators knowledge about uveitis and the underlying mechanism of disease, the investigators propose collecting blood from patients with uveitis, isolating DNA and sequencing the DNA to identify genetic mutations or associations in these patients.
Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC
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Can we predict who will worsen? new study analyzes 2000 PE patients
Knowledge-focused OngoingThis multi-center retrospective study collected clinical, laboratory, and CT pulmonary angiography parameters with acute pulmonary embolism patients from admission to predict adverse outcomes within 30 days after admission into hospital.
Sponsor: Shengjing Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC
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Gene test could predict heart attack and stroke risk
Knowledge-focused OngoingSeveral studies have shown that the efficacy of clopidogrel for secondary prevention of major adverse cardiovascular events (MACE), including acute coronary syndrome, depends on the polymorphism of the CYP2C19 gene. However, studies with large sample sizes and long-term follow-up…
Sponsor: University of Florida • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:01 UTC
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Antibiotics for gas incontinence? small trial shows promise
Symptom relief CompletedThe objectives of this work are: 1/to estimate the frequency of a positive glucose breath test in favour of a small intestinal bacterial overgrowth in a population of patients consulting for gaz incontinence by comparison to a population of control subjects; 2/to estimate versus …
Phase: PHASE3 • Sponsor: University Hospital, Rouen • Aim: Symptom relief
Last updated Jun 27, 2026 12:33 UTC
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Plant-Based Omega-3s tested for heart health in High-Risk patients
Disease control CompletedThe overall aims of the present project are to investigate the impact of a nutritional approach based on omega-3 from vegetal origin on vascular function in hypertension associated with metabolic syndrome.
Phase: NA • Sponsor: University Hospital, Rouen • Aim: Disease control
Last updated Jun 27, 2026 12:07 UTC
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Bone-Building drug under the microscope: could speed up new osteoporosis treatments
Knowledge-focused CompletedPreviously the approach to treatment of osteoporosis has been to use medications which prevent excessive resorption of bone. More recently medications that build up new bone, i.e. anabolic treatments, have been, and are being, developed. The investigators would like to develop a …
Phase: PHASE4 • Sponsor: Sheffield Teaching Hospitals NHS Foundation Trust • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:36 UTC
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New ultrasound technique may catch diabetic heart damage early
Knowledge-focused CompletedDespite careful monitoring of patients with diabetes, it is so far difficult to predict the occurrence of cardiac events in the evolution. As shown by various studies conducted in patients with diabetes, cardiac involvement can be detected by abnormalities of diastolic or systoli…
Phase: NA • Sponsor: University Hospital, Bordeaux • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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Cleveland clinic launches asthma research to develop better tests and treatments
Knowledge-focused ENROLLING_BY_INVITATIONThe overall goal of the Asthma Inflammation Research \[AIR\] Translational Program is to create an integrated multidisciplinary team for the focused purpose of development of diagnostic and prognostic tests informative for airway inflammation, and for the design of innovative, ta…
Phase: EARLY_PHASE1 • Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:39 UTC
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Pesticides may harm egg quality, IVF study suggests
Knowledge-focused CompletedOocyte quality is a key limiting factor in female fertility which is primarily reflected in morphological features. Centrally located cytoplasm granulation (CLCG) is one type of cytoplasmic dimorphism exhibited by oocytes that could be linked to pesticide exposure with a signific…
Sponsor: Centre Hospitalier Universitaire, Amiens • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Past gum disease may impact Long-Term dental implant success
Knowledge-focused CompletedThis prospective cohort study evaluated the effect of periodontitis grading on peri-implant clinical and radiographic outcomes over a 60-month follow-up. Fifty-five partially edentulous patients were classified into three groups according to periodontal status: generalized aggres…
Sponsor: University of Campinas, Brazil • Aim: Knowledge-focused
Last updated Jun 28, 2026 00:00 UTC