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116076 trials found · Page 5185 of 5804
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Could inflammation after stroke trigger depression?
Knowledge-focused CompletedThis study is being done to see if there is a relationship between stroke, post-stroke depression, and measures of inflammatory and/or stress compounds in the blood. Brain injury, as caused by stroke, leads to an inflammatory response in the brain which in turn can influence infl…
Sponsor: Alexander Kusnecov, Ph.D. • Aim: Knowledge-focused
Last updated Jul 18, 2026 00:00 UTC
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Could a gut hormone protect your blood vessels during low blood sugar?
Knowledge-focused OngoingLow blood sugar can negatively affect how blood vessels function, and this can lead to an increase in the risk for heart attacks, strokes and other problems related to the stiffening and blockage of blood vessels. The purpose of this study is to learn if and how glucagon-like pep…
Phase: EARLY_PHASE1 • Sponsor: University of Maryland, Baltimore • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC
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Thousands join sarcoidosis registry to map disease journey
Knowledge-focused Recruiting nowThe goal of the study is to create a longitudinal record of patient reported outcomes for people living with sarcoidosis that maintains privacy. Patients report on the following: demographics, disease symptoms, diagnostic journey, provider experience, disease treatment, and burde…
Sponsor: Foundation for Sarcoidosis Research • Aim: Knowledge-focused
Last updated Jun 26, 2026 19:17 UTC
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Desmoid tumor study: is doing nothing the best medicine?
Knowledge-focused CompletedThis is a prospective, multicenter observational study under the umbrella of the ISG (Italian Sarcoma Group) evaluating local progression-free survival at 3 years of patients affected by extra-abdominal primary fibromatosis managed with front-line conservative approach and treate…
Sponsor: Fondazione IRCCS Istituto Nazionale dei Tumori, Milano • Aim: Knowledge-focused
Last updated Jun 26, 2026 16:31 UTC
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Canola oil may tame metabolic syndrome, study hints
Disease control CompletedMetS is an early stage of CVD and is an appropriate target for dietary interventions. MetS is a clustering of risk factors (abdominal obesity, elevated serum triglycerides, low HDL-cholesterol, hypertension, elevated fasting blood glucose) accompanied by low grade chronic inflamm…
Phase: NA • Sponsor: University of Manitoba • Aim: Disease control
Last updated Jun 26, 2026 15:03 UTC
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Hypnosis eases pain and anxiety during rectal cancer procedure, study finds
Symptom relief CompletedThe goal of this study is to compare a Self-Regulation Hypnotic Intervention (SRHI) to the standard procedure (Treatment As Usual with analgesic and sedative agents) for pain and anxiety management during rectal cancer brachytherapy. Hypnotizability of patients undergoing this pr…
Phase: NA • Sponsor: Sir Mortimer B. Davis - Jewish General Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 13:01 UTC
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Brain wave test may reveal hidden thoughts in brain injury patients
Knowledge-focused CompletedThe main objective of this study is to describe differential cognitive processing of various stimuli by a population of control subjects and a population of patients with selective cognitive deficits or altered states of consciousness by using dedicated ERP paradigms and high-den…
Phase: NA • Sponsor: University Hospital, Limoges • Aim: Knowledge-focused
Last updated Jun 28, 2026 00:00 UTC
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Teens with PCOS may face hidden liver risks, study investigates
Knowledge-focused TerminatedThis project focuses on an at-risk adolescent and young adult population who may gain long-term health benefits from detection of risk factors at a young age. The primary aims of this proposal are: 1) To observe whether adolescents and young adults with Polycystic Ovary Syndrome …
Sponsor: Columbia University • Aim: Knowledge-focused
Last updated Jul 04, 2026 00:00 UTC
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Bone loss mystery in anorexia: hormones may hold the key
Knowledge-focused CompletedThe mechanism of bone loss in anorexia nervosa is complex. Marrow adipose tissue seems to play a role in the regulation of bone metabolism. Adipocytes secrete cytokines and adipokines that either stimulate or inhibit adjacent osteoblasts. This study consist to explore the relatio…
Sponsor: University Hospital, Lille • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:02 UTC
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Could overeating be like addiction? brain study explores link
Knowledge-focused CompletedThe P300 is one of the cognitive wave of the Event-Related Potential (ERP) that is used to investigate the cognitive process. The P300 component are accepted as electro-physiological markers of neuropsychiatric disorders like alcoholism or drug addiction. Recent scientific data …
Phase: NA • Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC
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Massive heart surgery study aims to uncover hidden risks
Knowledge-focused Recruiting nowIdentify factors that contribute to perioperative morbidity and mortality in patients undergoing cardiac surgery that involves cardiopulmonary bypass. Identify factors that affect perioperative morbidity and mortality in patients undergoing cardiac surgery.
Sponsor: University of California, Davis • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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New biopsy technique aims to unlock prostate Cancer's secrets
Knowledge-focused CompletedThe investigators hypothesize that this single-cell analysis can be used to evaluate prostate needle-core biopsies prospectively even in non-homogenous samples by providing profiles of proteomic and phenotypic signatures. These profiles will in turn enable better predictions of t…
Sponsor: Yale University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:05 UTC
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Immune drug rituximab tested to shrink prostate tumors before surgery
Disease control CompletedThere is now substantial evidence that B cells are recruited into prostate cancers by CXCL13 released by the tumor cells. B cells release lymphotoxin which drives malignant cell proliferation through the NFkB pathway. This is a pilot trial in 18 patients to determine whether depl…
Phase: EARLY_PHASE1 • Sponsor: Christopher Kane • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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Which cancer follow-up care model works best? large study seeks answers.
Knowledge-focused CompletedThe Evaluating Cancer Survivorship Care Models project is an innovative 3-year study that is collecting data to help understand how to best deliver follow-up care to cancer survivors. Cancer is a complex disease requiring complex treatments that can cause lasting impacts after tr…
Sponsor: George Washington University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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Scientists hunt for Muscle's secret Fat-Burning signals
Knowledge-focused OngoingThe purpose of this study is to collect data to help researchers identify factors, such as certain proteins or genetic codes, that are secreted from muscle that are associated with the beneficial effects of exercise.
Phase: NA • Sponsor: AdventHealth Translational Research Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:02 UTC
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Special drink before surgery may cut complications
Symptom relief CompletedThe purpose of this study is determine if using Impact Advanced Recovery® before and after RC surgery helps reduce surgical complications.
Phase: EARLY_PHASE1 • Sponsor: Jill Hamilton-Reeves, PhD RD LD • Aim: Symptom relief
Last updated Jun 27, 2026 12:07 UTC
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Rare genetic syndromes under the microscope: what 800 participants could reveal
Knowledge-focused Recruiting nowThe 3q29 deletion syndrome is caused by a deletion of a small part of human chromosome 3, and the duplication syndrome is caused by a duplication of this same small region. The purpose of this study is to understand the medical and behavioral consequences of these syndromes.
Sponsor: Rutgers, The State University of New Jersey • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:36 UTC
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New registry aims to unlock secrets of rare bone disease
Knowledge-focused Recruiting nowREM is a retrospective and prospective registry, finalized for care and research purposes. It is articulated in main sections - strongly related and mutually dependent on each other - corresponding to different data domains: personal information, clinical data, genetic data, gene…
Sponsor: Luca Sangiorgi • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC
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Brittle bone disease registry opens to track 5,000 patients
Knowledge-focused Recruiting nowROI is a retrospective and prospective registry, finalized for care and research purposes. It is articulated in main sections - strongly related and mutually dependent on each other - corresponding to different data domains: personal information, clinical data, genetic data, gene…
Sponsor: Luca Sangiorgi • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC
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Blood test showdown: which method spots melanoma cells better?
Knowledge-focused CompletedThe main objective of this study is to compare results for the detection of circulating melanoma cells (CMC) using CellSearch versus EPISPOT (EPithelial ImmunoSPOT) techniques between a group of patients with metastatic melanoma and a group of hospitalized control patients.
Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC