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127005 trials found · Page 5009 of 6351
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Brain training without moving: new study hopes to unlock stroke recovery
Knowledge-focused Recruiting nowThis study focuses on electromyographic analysis of upper limb muscle activation in stroke survivors during Motor Imagery (MI) and Action Observation (AO) rehabilitation techniques. By measuring muscle activity in the wrist and finger flexors and extensors, the research seeks to …
Sponsor: University of Salamanca • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC
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Laser before numbing gel could mean less pain at the dentist
Symptom relief CompletedThis study tests whether using an Er,Cr:YSGG laser before applying numbing gel (lidocaine) can help reduce pain during dental procedures compared to traditional methods. Investigators want to know: Does the laser make the numbing gel work better and longer? Does it lower pain a…
Early phase 1 • Sponsor: Li Zhen Zhong • Aim: Symptom relief
Last updated Jun 27, 2026 08:00 UTC
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New study aims to cut unnecessary antibiotics in newborns
Knowledge-focused Recruiting nowIn this study, three neonatal evidence-based antibiotic stewardship strategies will be implemented in Dutch hospitals. These include the early-onset sepsis (EOS) calculator, procalcitonin (PCT)-guided therapy, and IV-to-oral switch therapy. These strategies have been proven to be…
Sponsor: Franciscus Gasthuis • Aim: Knowledge-focused
Last updated Jun 26, 2026 18:52 UTC
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ER timing could be key to saving heart attack victims
Knowledge-focused Recruiting nowThis study examines the impact of emergency department (ED) management on short-term outcomes of nontraumatic adult out-of-hospital cardiac arrest (OHCA) patients. Conducted by a research team at National Taiwan University Hospital and its affiliated hospitals, including branches…
Sponsor: National Taiwan University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC
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Could a simple headband predict brain damage after cardiac arrest?
Knowledge-focused OngoingThis study aims to optimize the treatment of out-of-hospital cardiac arrest (OHCA) by focusing on neurological outcomes through Bispectral Index (BIS) monitoring. It will evaluate the feasibility of BIS monitoring in the prehospital phase, assess the need for sedation based on BI…
Sponsor: Medical University of Graz • Aim: Knowledge-focused
Last updated Aug 14, 2026 00:00 UTC
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Dead tooth brought back to life? new pilot study shows promise
Disease control CompletedThis pilot clinical study evaluated the clinical, radiographic, and functional outcomes of autologous pulp transplantation combined with concentrated growth factor (CGF) in mature permanent teeth with pulp necrosis and periapical lesions. Treated teeth were followed for 12 months…
Sponsor: Kahramanmaras Sutcu Imam University • Aim: Disease control
Last updated Jun 27, 2026 08:08 UTC
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Blood test may replace biopsies for rare lymphoma monitoring
Knowledge-focused OngoingThe purpose of this study is to assess the feasibility of analyzing circulating tumor DNA (ctDNA) as a biomarker using the shallow whole genome sequencing (lpWGS) technique coupled with deep sequencing of a targeted panel of genes (NGS), in a population of patients with newly dia…
Sponsor: Centre Henri Becquerel • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:07 UTC
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Antibody clues after stem cell transplants could prevent rejection
Knowledge-focused CompletedDonor specific anti-HLA antibody (DSA) is closely related not only to primary graft rejection (GR) after HLA-incompatible transplantation, but also to the occurrence of primary PGF. Desensitisation therapy can reduce the level of DSA in patients and decrease the incidence of PGF …
Sponsor: Peking University People's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:08 UTC
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New ultrasound technique peers into newborn brains without radiation
Knowledge-focused Recruiting nowThe aim of our study is to investigate changes of brain perfusion and elasticity in neonates during the time that a neonate is adapting to live outside the womb and during diseases that are suspected to affect neonatal brain perfusion. We use contrast enhanced ultrasound (sulphur…
Phase 3 • Sponsor: Turku University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC
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Can metacognitive therapy help depressed workers return to work?
Knowledge-focused Recruiting nowDepression and anxiety affects levels of function across different levels like work, increasing levels of sick leave and as well as cognitive functioning. In the current study patients at risk of sick leave with depression and anxiety receive metacognitive therapy and work focus …
Sponsor: Norwegian University of Science and Technology • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:13 UTC
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Study tracks young Gymnasts' bodies to uncover injury secrets
Knowledge-focused Completedassessment of the musculoskeletal system will be performed twice a year, for three years of young gymnasts.
Sponsor: University of Haifa • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:14 UTC
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Which anesthesia is safer for frail Seniors' hearts during scopes?
Knowledge-focused Recruiting nowThis study aims to compare the effects of conscious sedation and intravenous general anesthesia on cardiovascular events in frail patients undergoing digestive endoscopy diagnosis and treatment.
Sponsor: Beijing Friendship Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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New HOLD-B score could revolutionize emergency bleeding risk assessment
Knowledge-focused CompletedUpper gastrointestinal bleeding (UGIB) remains a common and potentially life-threatening emergency condition requiring early risk stratification to guide clinical management. Although several validated scoring systems such as Rockall, Glasgow-Blatchford Score (GBS), AIMS65, H3B2,…
Sponsor: Izmir Katip Celebi University • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC
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Brain zaps reveal how dyslexic teens learn new words
Knowledge-focused CompletedThe purpose of the proposed study is to use transcranial magnetic stimulation (TMS) to evaluate a neurobiological model of spoken word learning in older youth. Specifically, it is hypothesized that: (1) inhibition of the left dorsal stream will impact subsequent learning, process…
Sponsor: Georgia State University • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC
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Simple gum and heat tricks may speed Post-Surgery recovery
Symptom relief CompletedThe passage discusses the recovery of gastrointestinal (GI) function after abdominal surgery and the potential impact on patient comfort. After surgery, small bowel activity typically returns to normal within a few hours, gastric activity within 24-48 hours, and colonic activity …
Sponsor: Istanbul Medeniyet University • Aim: Symptom relief
Last updated Jun 27, 2026 12:01 UTC
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New device beats clips for bleeding control in gallbladder surgery
Disease control CompletedThis randomized clinical trial compared titanium clips and LigaSure (a vessel sealing device) for controlling bleeding during laparoscopic gallbladder surgery. A total of 114 patients were divided into two equal groups, with one group receiving clips and the other treated using L…
Sponsor: Wah Medical college , POF hospital • Aim: Disease control
Last updated Jun 27, 2026 12:05 UTC
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Your own tooth and blood may help preserve jawbone after extraction
Disease control Completed* The aim is to evaluate post extraction hard tissue changes following ridge preservation using partially demineralized dentin block versus L-PRF block in intact socket in the esthetic zone. * The main question: In patients with un restorable tooth, Will ridge preservation using …
Sponsor: Cairo University • Aim: Disease control
Last updated Jun 27, 2026 12:38 UTC
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Antibiotics before endoscopy: do they prevent infections in liver patients?
Knowledge-focused CompletedWhether prophylactic antibiotics should be administered in the endoscopic secondary prevention of GVB or not is unclear. In this retrospective study, we are aimed to evaluate whether prophylactic antibiotics confer advantages in the endoscopic secondary prevention of cirrhotic pa…
Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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Saliva test reveals best pain relief for Open-Heart patients
Symptom relief CompletedThis study evaluated the effects of parasternal block and wound site infiltration on postoperative pain in patients undergoing median sternotomy. Patients were allocated to receive parasternal block, wound site infiltration, or standard systemic analgesia. Salivary opiorphin leve…
Sponsor: Ataturk University • Aim: Symptom relief
Last updated Jun 27, 2026 13:00 UTC
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New care bundle slashes IV complications in kids at ER
Prevention CompletedThis quasi-experimental study evaluates the effectiveness of a care bundle in preventing peripheral intravenous catheter (PIVC)-related infiltration and phlebitis in pediatric emergency department patients. The care bundle includes interventions such as nurse education, hand hygi…
Sponsor: Istanbul University - Cerrahpasa • Aim: Prevention
Last updated Jun 27, 2026 14:00 UTC