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116076 trials found · Page 4742 of 5804
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Florida launches brain disease biobank to fuel future discoveries
Knowledge-focused OngoingThe purpose of this study is to create a state-wide biorepository and resource center for cerebrovascular diseases in Florida, which will include collecting medical history information and blood from subjects affected by cerebrovascular disease. The information and blood samples …
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:32 UTC
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Protein and exercise may stop muscle loss after bariatric surgery
Disease control Recruiting nowThe aim of this clinical trial is to investigate the effectiveness of collagen, considered a new approach to prevent muscle mass loss after bariatric surgery, and to demonstrate the relationship between this effect and exercise. The key questions it aims to answer are: Does whey…
Phase: NA • Sponsor: Medipol University • Aim: Disease control
Last updated Jun 27, 2026 08:06 UTC
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Cocoa drink may shield aging arteries from sitting slump
Symptom relief CompletedSitting time is high in older adults and has been shown to temporarily impair endothelial function and blood pressure. Flavanols, plant-derived compounds, acutely enhance endothelial function and reduce Blood pressure in older adults. The aim of this study is to investigate wheth…
Phase: NA • Sponsor: University of Birmingham • Aim: Symptom relief
Last updated Jun 27, 2026 08:01 UTC
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Does anesthesia choice affect immune cells during breast cancer surgery?
Knowledge-focused CompletedRegional anesthesia and local anesthetics have proven anti-inflammatory and antitumor effects as well as their analgesic properties. On this trial, the investigators are searching anesthetic techniques affect on the leukocyte, platelet-lymphocyte count and ratios, total amount o…
Sponsor: Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital • Aim: Knowledge-focused
Last updated Jun 26, 2026 13:38 UTC
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Old stroke data gets a modern check: do newer drugs lower risk?
Knowledge-focused OngoingThe purpose of this study is to build upon trials done over 30 years ago, which did not include statins, new antiplatelet agents, and newer antihypertensive medications. Since the landmark trials (NASCET, ECST), there have been new developments in medical stroke prevention, which…
Sponsor: University of Maryland, Baltimore • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:55 UTC
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New scanner could replace CT for kids with cystic fibrosis
Knowledge-focused CompletedThe purpose of this study is to determine the ability of electrical impedance tomography (EIT) to identify structural and functional physiological changes that occur with disease progression in cystic fibrosis patients. The investigators also aim to determine whether EIT can serv…
Sponsor: University of Colorado, Denver • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC
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New tool helps keep dementia patients safe at home
Knowledge-focused CompletedThe main objective of this study is to adapt the Canadian French version of the safety assessment scale for use in France. The Safety Assessment Scale was developped for community healthcare providers working with elderly people with dementia who are being cared for at home, to a…
Sponsor: Groupe Hospitalier de la Region de Mulhouse et Sud Alsace • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC
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Breathing problems in brittle bone disease: new study seeks answers
Knowledge-focused OngoingOsteogenesis imperfecta (OI) is a group of congenital and heritable bone disorders that currently affects at least 50,000 people in the United States. OI varies in severity from perinatally lethal to mild forms. The majority of cases is caused by a dominant mutation in type I col…
Sponsor: Baylor College of Medicine • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:09 UTC
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Water and touch: a new hope for crying babies?
Symptom relief CompletedAlthough various complementary health approaches have been examined to alleviate colic symptoms, there seems to be a limited number of studies on SPA and massage applications. For this reason, the study was planned to determine the effectiveness of nurses' baby SPA and massage pr…
Phase: NA • Sponsor: Yuzuncu Yil University • Aim: Symptom relief
Last updated Jun 27, 2026 08:05 UTC
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Can a simple pH change make dental shots Pain-Free?
Symptom relief CompletedThe purpose of this study is to evaluate the effect of pH adjustment of the solution of articaine 4% with epinephrine 1:100.00, on the efficacy of anesthesia with the usage of a local anesthesia device that is needle-free (Comfort-In), and uses pressure implementation. An additio…
Phase: NA • Sponsor: Aristotle University Of Thessaloniki • Aim: Symptom relief
Last updated Jun 27, 2026 08:08 UTC
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Heated acupuncture needles show promise for stubborn constipation
Symptom relief CompletedThis study aims to compare the effectiveness of two different acupuncture techniques for treating a specific type of chronic constipation, known in Traditional Chinese Medicine as "Yang deficiency type" chronic functional constipation. Chronic functional constipation is a common…
Phase: NA • Sponsor: The First Affiliated Hospital of Henan University of Traditional Chinese Medicine • Aim: Symptom relief
Last updated Jun 27, 2026 11:03 UTC
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Melanoma treatment patterns in japan: what Real-World data reveals
Knowledge-focused CompletedThe aim of this study was to describe the patient profile and treatment patterns of adult melanoma patients that were treated with either dabrafenib and trametinib (Dab+Tram) or encorafenib and binimetinib (Enco+Bini) between 01 January 2012 and 30 November 2021 in Japan.
Sponsor: Novartis Pharmaceuticals • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Can a smartphone app prevent kidney stones from coming back?
Knowledge-focused TerminatedWe plan to investigate whether usage of a mobile health platform for surveillance of stone formers by itself or as an adjunct to standard office-appointments will improve patient compliance and adherence to treatment guidelines and ultimately improve patient care, satisfaction, q…
Phase: NA • Sponsor: Northwestern University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:13 UTC
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Scientists investigate why tired muscles make older adults unsteady
Knowledge-focused Recruiting nowMuscle fatigue is one of the clinical symptoms in elderly people and demonstrates task dependency and muscle dependency. Muscle fatigue has been shown to negatively impact postural control, physical activity, and quality of life. However, the evidence for the influence of muscle …
Sponsor: Chang Gung Memorial Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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Can women give themselves the birth control shot after an abortion? study says maybe.
Disease control CompletedMultiple prior studies have compared self-administered Subcutaneous Depot Medroxyprogesterone Acetate(DMPA-SC) to both provider-administered DMPA-SC and Intramuscular Depot Medroxyprogesterone Acetate (DMPA-IM) and found that continuation rates for self-administered DMPA-SC are h…
Phase: PHASE4 • Sponsor: Northwestern University • Aim: Disease control
Last updated Jun 27, 2026 09:04 UTC
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Can a simple drink help blood cancer patients recover from stem cell transplants?
Disease control CompletedMalnutrition is common after haematopoietic stem cell transplantation (HSCT), and is a well-known prognostic factor for survival. HSCT-associated treatments are metabolic and digestively intolerant, hence can induce a significant reduction in oral intake. Thus weight loss, as wel…
Phase: NA • Sponsor: RenJi Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:31 UTC
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Sticky patch could replace needle biopsies for Kids' moles
Knowledge-focused ENROLLING_BY_INVITATIONA study to understand the clinical utility of noninvasive adhesive skin biopsies in pediatric patients by exploring whether DermTech Pigmented Lesion Assay (PLA) genetic risk analysis of suspicious lesions in children correlates with histopathological diagnosis.
Phase: PHASE1 • Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:36 UTC
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Resiliency program aims to boost mental health in childcare centers
Knowledge-focused CompletedThe purpose of the study is to further develop and examine the Jump Start Plus COVID Support (JS+CS) program, which encourages improved psychosocial functioning by promoting resiliency in childcare centers.
Phase: NA • Sponsor: University of Miami • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:37 UTC
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New training aims to help doctors spot domestic violence in veterans
Knowledge-focused CompletedVeterans and their families are more likely to experience forms of family violence like intimate-partner violence and child maltreatment. Evidence suggests that healthcare and social service providers (HSSPs) need more training to effectively and confidently recognize and respond…
Phase: NA • Sponsor: McMaster University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:09 UTC
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New study tests if bone punctures help jaw expansion in adults
Knowledge-focused CompletedRapid palatal expansion aims at skeletally correcting the transverse maxillary deficiency by applying forces to separate the mid-palatal suture. In adult patients, the separation of the mid-palatal suture may not be possible due to its increased interdigitation. Miniscrew-assiste…
Phase: NA • Sponsor: Alexandria University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC