Vanderbilt University Medical Center

This study tests whether sending patients home within 6 hours of bariatric surgery is as safe as keeping them overnight. 200 adults with obesity will be randomly assigned to same-day discharge or an overnight stay. The main goal is to see how many people need emergency care withi…

This study compares two ways to remove blood clots from the brain during a stroke. About 500 adults who have a stroke from a large blocked artery will be randomly assigned to one of two standard techniques: a cyclic 'plunger' method or a steady suction method. The goal is to see …

This study tests a drug called 2-HOBA in 12 adults with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs strains the heart. The goal is to see if the drug is safe and can improve heart function and blood vessel health. Participants must be…

This study tests a drug called 2-HOBA in 20 adults with salt-sensitive high blood pressure. The drug aims to calm overactive immune cells that may worsen blood pressure when salt is eaten. Researchers will measure blood pressure changes and blood vessel health after taking 2-HOBA…

This study tests if combining a gentle electrical brain stimulation (tDCS) with computer-based memory games can improve thinking and memory in adults over 60 with recurrent depression. Participants will be assigned to one of three groups to compare different combinations of activ…

This study looks at whether antibiotics are truly needed for mild diverticulitis. About 100 adults with left-sided diverticulitis will take either two antibiotics or a placebo daily for 10 days, along with standard pain relief and diet changes. The main goal is to see if a larger…

This study tests whether giving the numbing drug lidocaine through an IV during and after major surgery helps patients recover faster. About 2,290 adults having elective non-cardiac surgery will receive either lidocaine or a placebo. The goal is to see if lidocaine reduces hospit…

This study tests whether a special gel containing carbon dioxide (carboxytherapy paste) can reduce redness and swelling after microneedling, a cosmetic procedure for facial aging. Twenty adults will receive the gel on one side of their face and a placebo on the other, then be mon…

This study looks at whether adding Botox injections to the jaw and temple muscles can improve symptoms of facial synkinesis, a condition where facial muscles move involuntarily after nerve injury. About 50 adults who already get standard Botox for synkinesis will try both their u…

This study will test a new type of colonoscope called the Magnetic Flexible Endoscope (MFE) in 6 people with stable inflammatory bowel disease (IBD). The MFE uses a magnet at its tip, moved by an external robotic arm, to gently navigate through the colon. The goal is to see if th…

This study compares two common therapy methods for stroke patients in the hospital: having physical and occupational therapy together (co-treatment) or separately (individual treatment). About 567 adults admitted for stroke will be randomly assigned to one approach. Researchers w…

This study tests whether an electronic decision-support system can help primary care doctors and specialists better manage patients with metabolic-dysfunction associated steatotic liver disease (MASLD). The tool will prompt doctors to refer high-risk patients to liver specialists…

This study is creating a decision aid for people with a rare heart condition where a coronary artery comes from the wrong side of the aorta (R-AAOCA). The goal is to help patients and families weigh the risks of surgery versus monitoring, reduce anxiety, and feel more confident i…

This study will test a new type of eye imaging called OCT in 24 adults who have had a cornea transplant. The goal is to see if the new method can take clearer pictures of the eye to help doctors better detect eye diseases. Participants will have their eyes scanned with the new de…

This study looks at a new way to check if the bowel is healing properly after surgery. Instead of using a dye that can cause allergies, doctors will measure oxygen levels in the tissue. The goal is to see if low oxygen can predict leaks or narrowing of the bowel. About 80 adults …