Vanderbilt University Medical Center

This study tests a drug called 2-HOBA in 12 adults with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs strains the heart. The drug aims to reduce harmful molecules and improve heart function. Participants must be on stable PAH medication…

This study tests two methods doctors use to remove blood clots from the brain during a stroke. About 500 adults who have a large-vessel blockage will be randomly assigned to either a cyclic (pulsing) suction technique or a static (steady) suction technique. The goal is to see whi…

Facial synkinesis causes unwanted muscle movements after nerve injury. Standard Botox targets facial muscles, but patients often report jaw and temple injections help too. This study with 50 adults compares standard Botox alone versus standard plus jaw/temple Botox to see if the …

This study tests if combining a gentle electrical brain stimulation (tDCS) with computer-based memory games can improve thinking and memory in adults over 60 with recurrent depression. Participants will be assigned to one of three groups to compare active stimulation plus targete…

This study looks at two common ways to help people recover after a stroke: having physical and occupational therapy separately (individual treatment) or together (co-treatment). About 567 stroke patients will take part to see which method leads to better mobility and daily living…

This study looks at whether giving each patient on a ventilator a personalized oxygen target—based on their own health data—can reduce deaths compared to standard care. About 3,000 adults in the ICU will take part. The goal is to see if a tailored approach to oxygen levels improv…

This study looks at a new way to check if the bowel is healing properly after colon or rectal surgery. Instead of using a dye that can cause allergies, doctors will measure oxygen levels in the gut lining. The goal is to see if low oxygen can predict dangerous leaks or blockages.…

This early study will test a new device called the Magnetic Flexible Endoscope (MFE) in 6 adults with stable inflammatory bowel disease (IBD). The MFE uses a tiny camera and magnet at its tip, guided by an external robotic magnet, to travel through the colon. Researchers want to …

This study tests whether a supplement-like drug called 2-HOBA can lower blood pressure and reduce immune system overactivity in people with lupus. 42 adults with stable lupus and mildly high blood pressure will receive either the drug or a placebo for 4 weeks, then switch after a…