Uppsala University

This study compares 6 months versus 12 months of immunotherapy (nivolumab or pembrolizumab) in 1,792 people with high-risk melanoma who had surgery. The goal is to see if the shorter treatment prevents cancer from coming back just as well, while causing fewer side effects and req…

This study tests whether an oral antibiotic called pivmecillinam works as well as standard treatments for febrile urinary tract infections (UTIs) in adults. Hospitalized patients who have already responded to IV antibiotics will be randomly assigned to pivmecillinam or usual care…

This study looks at people with stage 4 pancreatic neuroendocrine tumors (a rare, slow-growing cancer) that cannot be cured. It compares two approaches: near-total tumor removal surgery plus medical treatment versus medical treatment alone. The goal is to see if surgery helps pat…

This study tests whether a vacuum-sealed dressing (negative pressure wound therapy) can reduce wound complications like infection or reopening after emergency abdominal surgery. About 720 adults with a large midline incision will be randomly assigned to get either the vacuum dres…

This study tests two methods of pain relief after open abdominal surgery in children aged 1 to 15. One method uses a nerve block (TAP-block) and the other uses a small tube placed in the wound to deliver numbing medicine. The goal is to see which approach reduces the need for str…

This study tests a new group therapy for teens aged 15-18 with autism and anxiety or depression. The therapy focuses on changing how they think about their thoughts. Researchers want to see if the treatment is practical and liked by participants, and if it helps reduce symptoms a…

This study tests whether helping people sleep better for 4 weeks before knee or hip replacement surgery can reduce pain and speed recovery afterward. About 100 adults with insomnia and osteoarthritis will receive either a brief sleep therapy (CBT-I) or sleep education before thei…

This study looks at adults with a displaced fracture of the outer collarbone. It compares non-surgical treatment (like using a sling) with surgery to see if avoiding an operation leads to similar arm and shoulder function after one year. About 96 participants will be randomly ass…

This study looks at how eating a Western-style unhealthy diet compared to a high-fiber diet changes sleep quality, heart rate, and metabolism. Researchers will monitor 24 healthy adults aged 18-32 using wearable devices and sleep tests. The goal is to understand the link between …

This study is observing how well robotic-assisted surgery places screws in the spine compared to traditional methods. Researchers will track screw accuracy, how quickly surgeons learn the robot, and whether patients need repeat surgery within two years. Up to 7,200 participants o…

This study aims to find blood markers that show if a child's brain has been injured by cancer treatment. Researchers will collect blood samples from 560 children with brain tumors before and after surgery, radiation, or chemotherapy, and compare them to healthy children. The goal…

This study aims to understand how inflammation from infections or major surgery can harm the kidneys. Researchers will measure certain proteins in urine, blood, and sputum from 100 ICU patients with sepsis, after surgery, or after poisoning. The goal is to find early markers that…

This study looks at whether measuring the water outside cells (extracellular water) can help doctors better understand fluid status in adults with sepsis who are in intensive care. Researchers will measure this water in 20 patients receiving standard care. The goal is to see if t…

This study looks at how the body processes antibiotics in 150 people with a serious heart infection called endocarditis. Researchers will measure drug levels in the blood and use that data to create a model that predicts the best dose for each patient. The goal is to make sure ev…

This study interviews 30 women who have experienced intimate partner violence and are taking part in a resilience-focused program at Uppsala University Hospital. Researchers want to learn how well the program meets each woman's needs and supports her recovery. The goal is to impr…

This study is testing a Swedish version of a short 8-question shame scale called EISS. Researchers will ask 350 adults (300 from the public and 50 from a clinic) to fill out the questionnaire along with other surveys. The goal is to see if the Swedish version works well for measu…

This study is observing 2,000 children (0-16 years old) from hospitals around the world to see how often kidney injury happens after non-heart surgery. Researchers will track kidney function with blood and urine tests to find early warning signs. The goal is to better understand …

This study aims to find out if spinal fusion surgery truly helps people with long-term low back pain. Ninety adults who have not improved with other treatments will be randomly assigned to receive either fusion surgery or a sham procedure (incision only, no fusion). Neither the p…