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Could tailored antibiotic doses save more endocarditis patients?

NCT ID NCT04647331

Knowledge-focused Sponsor: Uppsala University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is collecting data from 150 patients with a serious heart infection called endocarditis. Researchers will measure antibiotic levels in the blood and use that information to build a computer model. The goal is to find the best dose for each patient, which could help more people survive and avoid side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
beta-lactam antibiotics (ampicillin, penicillin G, cefotaxime, cloxacillin)
What this could lead to
If successful, this could lead to personalized antibiotic dosing for endocarditis patients, potentially improving survival and reducing side effects.
What could go wrong
This is an observational study, not a treatment trial. The model needs validation and may not improve outcomes in practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2021

Expected to finish

Dec 2025

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients in Uppsala University Hospital treated for verified or suspected left or right sided endocarditis in nativ or prosthetic valve with intravenous antibiotic therapy (ampicillin, cefotaxime, cloxacillin or penicillin G).

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Verified or suspected left or right sided endocarditis in native or prosthetic valve * Intravenous antibiotic therapy with either ampicillin, penicillin G, cefotaxime or cloxacillin * Signed informed consent to participate in study Exclusion Criteria: * \<18 years of age * Ongoing dialysis

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Conditions

The condition(s) this trial relates to.

endocarditis infective endocarditis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Infective endocarditis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    3 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Karolinska University Hospital

    NOT_YET_RECRUITING

    Stockholm, Sweden

  • Sahlgrenska University Hospital

    ACTIVE_NOT_RECRUITING

    Gothenburg, Sweden

  • Skåne University Hospital

    RECRUITING

    Lund, Sweden

  • Uppsala University Hospital

    RECRUITING

    Uppsala, Sweden

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