University Of Texas Southwestern Medical Center

This study is testing if adding precise, high-dose radiation (SABR) to the standard drug osimertinib can better control advanced lung cancer with specific genetic changes (EGFR mutations). The goal is to target and destroy tumors that don't fully respond to the drug alone, hoping…

This study is testing if the medication semaglutide can help control blood sugar in people with type 2 diabetes who are receiving dialysis for kidney failure. Researchers will compare weekly injections of semaglutide to a placebo (dummy medicine) in 43 participants over about a y…

This study is testing a two-part treatment before surgery for women with a hard-to-treat type of breast cancer (triple-negative). Doctors first freeze the tumor (cryoablation) and then give an immunotherapy drug (pembrolizumab) to help the body's immune system fight the cancer. T…

This study is testing a focused radiation treatment called stereotactic radiosurgery for patients with six or more brain metastases (tumors that have spread to the brain). The first goal is to find the safest, most effective dose. The second goal is to measure how much the treatm…

This study is testing whether combining two existing drugs, afatinib and prednisone, can help control advanced squamous non-small cell lung cancer in people who have already tried other treatments. The goal is to see if this combination can slow the cancer's growth and extend lif…

This study aims to understand the safety and effects of switching patients with relapsing forms of multiple sclerosis (MS) from the medication natalizumab to a different pill called cladribine tablets. It will follow 40 adults for two years to see how their immune cells and disea…

This study is testing a precise, non-invasive radiation treatment for people with small, growing kidney tumors. The goal is to see if this approach can stop the tumor from growing while preserving kidney function. Participants receive a short course of radiation over a few weeks …

This study is testing whether higher, more focused radiation doses can better control brain tumors that have spread from other cancers. It involves 135 adults with up to 10 small brain tumors who haven't had previous brain radiation. Researchers want to find the highest safe dose…

This study is testing whether a new automated tool in the electronic medical record can help patients with inflammatory bowel disease (IBD) get their follow-up appointments on time. The goal is to see if better, more timely follow-up care leads to fewer hospital visits, less need…

This study is testing if a short, high-dose radiation treatment given before surgery is safe and effective for people with kidney cancer that has grown into a major vein (the IVC). The goal is to see if this approach helps control the cancer, reduces the risk of it spreading duri…

This study aims to find the highest, safest dose of targeted radiation for men with high-risk prostate cancer. It tests a precise, high-dose radiation technique on the prostate and surrounding pelvic area in 60 participants. The main goal is to see how much radiation the body can…

This study is testing if adding an experimental immunotherapy drug (APX005M) to standard radiation and chemotherapy before surgery helps shrink rectal tumors more effectively. It will involve 58 adults with locally advanced rectal cancer who have not had prior treatment. The main…

This early-stage study is testing a single, powerful dose of radiation given before surgery to women with early-stage breast cancer. The goal is to find the highest dose that is safe and effective at destroying the tumor. Researchers will carefully monitor patients for side effec…

This study is testing a new, highly focused radiation machine called the GammaPod for women with early-stage breast cancer. The goal is to see if delivering radiation in just 5 sessions can control the cancer while leading to better cosmetic outcomes than older radiation techniqu…

This study is testing whether a pill called Tofacitinib can slow down the growth of glioblastoma, a very aggressive brain cancer, when it comes back after initial treatment. It involves 17 adults with recurrent cancer who will take the pills daily in 28-day cycles. Doctors will u…

This study is testing whether adding a simple, color-changing carbon dioxide (CO2) detector to a breathing mask helps medical teams provide faster and more effective breathing support to newborns who need help right after birth. The device, called a Pedi-Cap, changes color when t…

This study aims to see if adding methadone to standard morphine pain medication better controls severe mouth pain in children aged 6-18 undergoing stem cell transplants. Researchers will compare pain levels, medication use, and recovery between children receiving the two-drug com…

This early-stage study is testing whether a new type of light therapy is safe and tolerable for people with progressive multiple sclerosis (MS). The main goal is to check for any side effects while also gathering initial information on whether the light can help reduce the severe…

This study aims to see if healthcare providers' skills in helping newborns breathe, which they practice on mannequins in a simulation lab, work the same way on real babies in the delivery room. Researchers will observe 120 respiratory therapists, comparing how well they minimize …

This study aims to understand how the brain controls actions like stopping or switching movements, which is often impaired in Parkinson's disease. Researchers will record brain activity directly from 125 Parkinson's patients during their scheduled deep brain stimulation surgery w…

This study is re-examining 90 children, now 6 years older, to understand how childhood obesity affects breathing, exercise ability, and feelings of breathlessness over time. Researchers are measuring body fat, lung function, and fitness to see if the effects of obesity get worse …

This study aims to understand the biological causes of rare, inflammatory nerve disorders like Neuromyelitis Optica and Transverse Myelitis. Researchers will follow 150 patients over time, collecting health data, questionnaires, and blood samples. The goal is to learn why treatme…

This study aims to understand how well people with short bowel syndrome can tolerate adding fiber to their liquid nutrition. Researchers will slowly introduce green beans into the diets of 60 participants and track their symptoms, weight, and changes in their gut bacteria. The go…

This study aims to understand how bone contributes to a substance called citrate in urine. Researchers will measure bone health and urine citrate in 25 people with untreated osteoporosis before and after they start standard bone medications. The goal is to gather basic knowledge …

This study aims to understand why some young people have trouble breathing and exercising after their first serious blood clot in the leg or lung. Researchers will follow 115 participants, aged 8 to 21, for a year, measuring their heart, lung, and muscle function during exercise …

This study aims to gather real-world information on a common procedure for liver cirrhosis called TIPS. It will follow 852 patients for up to 5 years after they get the shunt as part of their normal care. The goal is to create a database to answer key questions about how to best …