University Of Manchester

This trial is testing a new type of stem cell transplant for young adults (under 55) with a very high-risk form of acute myeloid leukemia that hasn't responded well to chemotherapy. The treatment uses stem cells from donated umbilical cord blood, but adds extra infusions of a typ…

This study aims to understand why a heart medication called mavacamten works better for some people with hypertrophic cardiomyopathy (HCM) than others. Researchers will follow 140 adults with HCM to see if the specific gene causing their condition or a gene that affects how the b…

This small pilot study is testing whether a form of talk therapy (cognitive-behavioural therapy) can be successfully adapted to be more culturally relevant for Black people of African and Caribbean heritage who experience psychosis. Six participants will receive up to 16 therapy …

This study is creating a large UK-wide registry to collect health information from people diagnosed with hypertrophic cardiomyopathy (HCM), a common inherited heart condition. By gathering data from about 2,500 participants over several years, researchers aim to better understand…

This study aims to understand how a specific heart medication (mavacamten) works in people with obstructive hypertrophic cardiomyopathy (HCM), a condition where the heart muscle thickens and obstructs blood flow. Researchers will use a specialized, non-invasive MRI scan to measur…

This study aims to understand if infertility or IVF treatments are linked to a higher risk of future heart and metabolic problems in women. Researchers will recruit 120 women in Manchester, some planning pregnancy and some who have already had a baby, to measure their heart and b…

This study is testing whether a simple online tool can help patients speak up about safety concerns during medical care. Researchers will ask 10,000 UK adults to use an 'if-then' planning tool, which links specific situations to planned actions, to see if it increases how often t…