University Of Manchester

This trial tests a new way to do a stem cell transplant for young adults (ages 16-55) with very aggressive acute myeloid leukemia (AML) that hasn't responded to chemo or has high-risk gene changes. It uses umbilical cord blood plus extra white blood cells (granulocytes) to try to…

This small study will test whether a culturally-adapted form of cognitive-behavioural therapy (CBT) is practical, acceptable, and safe for Black Sub-Saharan African and Caribbean people who experience psychosis. Six participants will attend up to 16 therapy sessions and complete …

This study looks at whether it is possible to run a larger trial that offers bereavement counselling to parents who have lost a baby late in pregnancy or shortly after birth. About 26 parents will be randomly assigned to receive either usual hospital bereavement care or usual car…

This study looks at whether infertility or IVF treatments are linked to heart and blood vessel problems in women. Researchers will compare the health of women planning pregnancy naturally or after IVF, and those who already had a baby. The goal is to understand any connections an…

This study looks at why the heart drug mavacamten works better for some people with hypertrophic cardiomyopathy (a condition where the heart muscle thickens). Researchers will check if a person's specific gene causing HCM and their natural ability to process medications (via the …

This study tests whether a short online planning exercise can help healthcare professionals raise and respond to safety concerns at work. About 1000 healthcare workers will be randomly assigned to either do the exercise or not, and then report their actions after 1 and 6 months. …

This study tests whether making simple IF-THEN plans helps patients raise safety concerns during healthcare visits. About 10,000 adults will be randomly assigned to either form these plans online or not. Researchers will track how often participants speak up over the next year.