University Of Manchester

This study is building a secure database of health information from 2,500 people with hypertrophic cardiomyopathy (HCM), an inherited condition that thickens the heart muscle. Researchers will collect routine medical data like heart scans, blood tests, and genetic information ove…

This study looks at whether the medication Camzyos (mavacamten) improves blood supply to the heart muscle in people with hypertrophic obstructive cardiomyopathy (HOCM). About 75 adults already prescribed Camzyos will get a special PET scan before starting the drug and again after…

This study aims to validate a gene-based test that identifies oxygen-starved (hypoxic) tumours, which often resist standard radiotherapy. Researchers will collect tumour samples and MRI scans from 30 adults with bladder or prostate cancer undergoing radiotherapy. If successful, t…

This study looks at how tumors and healthy tissues change during a course of radiotherapy. About 250 cancer patients and 10 healthy volunteers will have special MRI scans and give blood or urine samples. The goal is to find patterns that could help doctors target tumors more prec…

This study is creating a large registry of 600 people with immune-mediated inflammatory diseases (IMIDs) like arthritis or lupus to track their heart health over time. Researchers will collect routine medical data and blood samples to see if certain heart markers can predict futu…

This study aims to find factors that may cause pregnancy loss between 20 and 28 weeks, such as sleep position, smoking, and caffeine. Researchers will compare 316 women who experienced early stillbirth with 632 women who had a healthy pregnancy. The goal is to identify changes in…

This study follows 47 adults who are scheduled for a type of knee cartilage repair called autologous chondrocyte implantation (ACI). Researchers will measure knee movement, balance, and walking ability before surgery and again 6 months after. The goal is to understand how well th…

This study looks at a special clinic called the Rainbow Clinic, designed to support families who have lost a baby during pregnancy or shortly after birth. Researchers will ask 500 pregnant women attending these clinics across the UK to fill out questionnaires about their anxiety,…

This study aims to improve an AI system called Patchs that helps GP practices decide how urgently patients need care. Researchers will analyze data from over 226,000 patients to see how accurate the AI is and whether it treats everyone fairly. The goal is to make the AI better so…

This early study tests a new graphene-based electrode for brain mapping during surgery to remove brain tumors. Ten adults with glioma will have the device used alongside standard monitoring to check its safety and how well it records brain signals. Some participants who are awake…