University Of Arizona

This study tests a team of pharmacists and community health workers who work together to help African-American and Latino adults with high blood pressure take their medications as prescribed. The goal is to improve medication adherence and lower blood pressure. Participants must …

This study tests whether adding the drug tarlatamab to standard radiation is safe and effective for cancers that have a protein called DLL3. About 30 adults with cancers like melanoma, lung cancer, or glioblastoma will receive the combination. The goal is to find the best timing …

This study aims to improve treatment for obstructive sleep apnea (OSA) in people with Down syndrome by matching therapy to each person's specific cause of OSA. Researchers will compare a standard medication combination (atomoxetine and oxybutynin) with a personalized approach tha…

This study tests whether a natural brain chemical called allopregnanolone can safely slow or reverse memory loss in Alzheimer's disease. About 100 people aged 55-80 with mild to moderate Alzheimer's will receive either the drug or a placebo for several months. The main goal is to…

This study looks at whether omega-3 supplements can reduce inflammation and improve heart health in 200 healthy adults. Researchers want to see if a person's genetic makeup (specifically the FADS gene) and ancestry (African American vs. European American) affect how well omega-3s…

This study tests whether a smartphone app with reminders and education can help older adults (60+) with mild memory problems stick to their blood pressure medication routine. About 100 participants will use the app or receive standard education for 16 weeks. The goal is to see if…

This study tests a combination of two chemotherapy drugs (gemcitabine and docetaxel) given directly into the bladder for people with non-muscle invasive bladder cancer. It includes patients who have not had prior BCG therapy or whose BCG treatment failed. The goal is to see if th…

This study tests whether adding tadalafil (a drug often used for erectile dysfunction) to standard chemotherapy can help shrink stomach or gastroesophageal junction tumors before surgery. About 10 adults with resectable cancer will take tadalafil alone for two weeks, then combine…

This study tests whether a community health worker-led program can help Mexican-origin adults with fatty liver disease (MASLD) better understand their heart disease risk and adopt healthier habits. About 45 participants and their family or friends will take part. The goal is to s…

This study tests a special PET/CT scan (18F-Fluciclovine) to see if it can better detect brain metastases and tell the difference between active cancer and scar tissue from treatment. About 20 adults with known or suspected brain metastases will get the scan before and after thei…

This study tests whether telehealth tools can help more people aged 45-64 complete colorectal cancer screening. Researchers will compare screening rates before and after the intervention in 6,000 participants. The goal is to counter misinformation and make screening easier, espec…

This study tests a device worn on the wrist during sleep that applies gentle, on-and-off pressure to help relieve carpal tunnel syndrome. Researchers will compare symptom and function reports from 116 adults who use the device against standard care. The goal is to see if this sim…

This study tests whether a non-invasive brain stimulation technique called TMS can improve sleep in people with insomnia. Over 2 weeks, 144 adults will receive either real TMS to different brain areas or a sham (fake) treatment. Researchers will monitor sleep at home and in the l…

This study looks at whether patients can safely go home the same day as colon surgery. Researchers will track how many people need to come back to the hospital within 30 days. The goal is to see if same-day discharge is a good option for carefully selected patients.

This study tests if a drug called Pedmark (sodium thiosulfate) can reduce hearing loss in adults receiving cisplatin chemotherapy for cancers like testicular, head and neck, or thoracic cancer. About 25 participants will receive Pedmark alongside their standard chemo. The goal is…

This study tests a program to help Hispanics with knee osteoarthritis become more active. Participants pair up with a family member or close friend and receive live video sessions on exercise and education. The goal is to see if this approach improves symptoms and physical activi…

This study tests whether a personalized caffeine schedule helps people stay alert and think clearly during 62 hours of total sleep deprivation better than the usual caffeine recommendations. 180 healthy adults aged 18-39 will wear activity monitors and complete reaction time test…

This study tests whether a 10-day meditation app can lower anxiety and depression in firefighters. About 192 career firefighters will use pre-recorded audio sessions on their smartphones. The goal is to see if this simple, at-home tool can ease the mental strain of their demandin…

This study aims to see if a personalized sleep extension plan can help adults who regularly get 6 hours or less of sleep per night. Over 1,000 participants will use a FitBit to track their sleep and complete questionnaires on sleepiness, mental health, and thinking skills. The go…

This study tests whether a safe, noninvasive brain stimulation technique combined with online chair yoga can help manage chronic knee pain in older adults with Alzheimer's or related dementias. About 40 participants aged 60 and older, along with their caregivers, will do 14 super…

This study tests if 3D-printed ear tips are more comfortable and sound better than standard ones for people with hearing loss. Researchers will compare fit, sound quality, cost, and production time in 32 adults with hearing loss in both ears. The goal is to see if 3D printing can…

This study looks at whether watching Netflix or Disney shows in a small group for 90 minutes each week, over 6 weeks, can improve emotional awareness, anxiety, and depression. About 70 adults already receiving mental health treatment will take part. The goal is to see if shared v…

This study tests whether morning light exposure can help regulate mood, improve sleep, and reduce suicidal thoughts in military personnel. Researchers will enroll 480 service members with mild depression or more. Participants will use a light device each morning to see if it impr…

This study looks at whether a short nutrition and exercise program before cancer treatment is practical and helpful for American Indian patients. About 30 adults with any cancer type will eat walnuts and increase their walking for at least 3 weeks before starting treatment. Resea…

This study follows 250 adults undergoing pancreatic surgery to understand how the procedure impacts their quality of life over two years. Researchers will use surveys to track changes in physical, emotional, and social well-being. The goal is to help doctors and patients make bet…

This study looks at how a small area of skin reacts to simulated sunlight in 46 adults aged 40 and older. Researchers want to see if the skin of people who have had skin cancer responds differently than those who haven't. Participants will have four small skin samples taken over …

This study looks at whether being awake between 2:00 and 4:00 AM makes negative mood, poor decision-making, and suicidal thoughts worse. Adults who have had suicidal thoughts in the past six months will be tested in a lab and at home under different sleep conditions. The goal is …

This study collects and stores tumor, tissue, and blood samples from up to 10,000 cancer patients treated at the Arizona Cancer Center. The samples are kept in a secure database and used by researchers to better understand cancer. Participation is open to all cancer patients unde…

This study looks at whether doing intense exercise for two weeks before lung cancer surgery can change the tumor's surroundings and help the immune system fight better. Researchers will compare people who exercise with those who don't, and check tumor samples for changes. The goa…

This study tests whether 3D-printed ear tips for hearing aids are more comfortable and sound better than standard ones. Thirty adults with normal hearing will try both types and rate their experience. Researchers will also compare the cost and time to make each ear tip. The goal …