University Hospital Heidelberg

This phase 2 trial tests a shorter course of proton or carbon ion radiation (2-3 weeks instead of 5) given before surgery for extremity soft tissue sarcoma. The main goal is to see if this approach reduces wound healing problems after tumor removal. The study enrolls 42 adults wi…

This study compares two radiation therapies for people with 4 to 15 brain metastases from advanced cancer. One group gets stereotactic radiosurgery (SRS), a precise, short treatment in 1-2 sessions; the other gets whole-brain radiotherapy (WBRT) over 10 sessions. The goal is to s…

This study compares a new ambulatory (same-day) stroke care model to standard hospital care for patients aged 60 and older who have had a mild stroke or transient ischemic attack (TIA). Participants receive a full neurological assessment and treatment plan on the same day and the…

This phase 3 trial tests a new chemotherapy combination (CETEG) for adults with a slow-growing brain tumor called oligodendroglioma. The goal is to see if starting with chemo alone can delay or avoid radiation therapy, which can cause long-term cognitive and quality-of-life probl…

This study tests if the drug cyclosporine can reduce heart muscle damage in people with Takotsubo syndrome, also known as broken heart syndrome. About 204 adults at high risk for complications will receive either cyclosporine or a placebo shortly after diagnosis. Researchers will…

This study compares a new type of radiation therapy (MR-guided adaptive SBRT) to standard radiation for people with up to 3 liver tumors that started in another organ. The new method uses real-time MRI to better target the tumors and avoid harming nearby organs. About 90 adults w…

This study looks at people who have a brain bleed that also fills the fluid spaces inside the brain, causing dangerous pressure. Normally, doctors place a drain in the head to remove fluid. This trial adds a second drain in the lower back to see if it helps patients recover bette…

This study tests a new, faster radiation treatment using protons or carbon ions before surgery for a rare type of cancer called retroperitoneal soft tissue sarcoma. The goal is to see if this approach is safe and practical. About 64 adults whose tumors can be surgically removed w…

This study tests a precise type of radiation called proton beam therapy for women whose breast cancer has returned after a previous lumpectomy and radiation. The goal is to control the cancer while keeping side effects low. Twenty participants will receive 15 daily treatments, an…

This study tests a precise type of radiation called carbon ion re-radiotherapy for people whose head-and-neck cancer has returned or worsened after standard treatment. About 72 adults who cannot have surgery will receive this therapy to see if it causes fewer severe side effects …

This study tests how well PET/CT scans, along with other imaging, can define the exact edges of esophageal cancer before and after treatment. Researchers will compare these images to the actual tumor removed during surgery. The goal is to improve surgical planning and ensure all …

This study tests whether proton beam radiation causes fewer side effects than standard photon radiation in people with glioblastoma, an aggressive brain cancer. About 326 patients will receive either proton or photon therapy alongside standard care. The main goal is to see if pro…

This study looks at two types of radiation (proton and photon) given after prostate cancer surgery. The goal is to see if proton therapy causes fewer bowel problems and improves quality of life. About 900 men who have had their prostate removed will take part. The study also chec…

This study looks at why multiple myeloma patients fall and tests a personalized home exercise program to prevent falls. Sixty patients will do strength and balance exercises three times a week for six months, plus treadmill training. The goal is to see if the program is practical…

This study looks at whether using sedation instead of general anesthesia helps people having a specific type of stroke (vertebrobasilar) recover better after a procedure to remove a blood clot. About 128 adults with moderate to severe stroke symptoms will be enrolled. The goal is…

This study looks at how gender affects the way people with borderline personality disorder (BPD) see themselves and their relationships. Researchers will interview 15 people with BPD of different genders and use special tests to measure hidden thoughts. The goal is to better unde…

This study explores whether functional MRI can help doctors tell different types of interstitial lung disease apart and track how they change over time. About 200 adults with certain lung conditions will get MRI scans alongside standard CT scans. The goal is to see if MRI can pro…

This study looks at whether lying on your back for 5 days after a special corneal transplant (DMEK) helps the new tissue stay in place better than just 1 day. About 100 people with Fuchs corneal dystrophy will be randomly assigned to either 1 or 5 days of back-lying. Researchers …

This study looks at whether taking probiotics (with or without vitamin B12) can improve the health of the mouth's bacteria and reduce gum disease in adults with severe periodontitis. Participants will receive standard gum treatment plus either a probiotic lozenge, a probiotic wit…

This study collects information from 10,000 adults who have had hip or knee replacement surgery at Heidelberg University Hospital. Researchers will follow participants during routine check-ups to see how long the artificial joints last, how well they function, and what problems m…

This study is testing a simple blood test to monitor meningioma brain tumors after radiation therapy. Researchers will look at tiny particles in the blood to see if they can track tumor changes and predict outcomes without needing a surgical biopsy. The study involves 60 adults w…

This study is a registry that collects data from 200 adults with mediastinal lymphoma who receive proton radiotherapy. The goal is to track how well the treatment works and what side effects occur. Researchers will use this information to develop better planning guidelines for fu…