University Hospital Heidelberg

This study looks at people who have a brain bleed that also fills the fluid spaces inside the brain, causing dangerous pressure. Normally, doctors place a drain in the head to remove fluid. This trial adds a second drain in the lower back to see if it helps patients recover bette…

This study tests a new, faster radiation treatment using protons or carbon ions before surgery for a rare type of cancer called retroperitoneal soft tissue sarcoma. The goal is to see if this approach is safe and practical. About 64 adults whose tumors can be surgically removed w…

This study looks at whether a precise, short radiation treatment called CyberKnife is better than standard whole-brain radiotherapy for people with 4 to 15 brain metastases from cancer. The goal is to see if CyberKnife can maintain or improve quality of life and survival while be…

This study looks at whether staying on your back for 5 days after a cornea transplant helps the new tissue stay in place better than just 1 day. About 100 adults with Fuchs corneal dystrophy will be randomly assigned to either 1 or 5 days of lying flat. Researchers will measure g…

This study tests whether a shorter course of proton or carbon ion radiation (2-3 weeks instead of the usual 5 weeks) before surgery for soft tissue sarcoma of the arms or legs is safe and causes fewer wound healing problems. About 42 adults with resectable tumors will be enrolled…

This study tests a precise type of radiation called proton beam therapy for women whose breast cancer has returned after a previous lumpectomy and radiation. The goal is to control the cancer while keeping side effects low. Twenty participants will receive 15 daily treatments, an…

This study tests if the drug cyclosporine can reduce heart muscle damage in people with Takotsubo syndrome, also known as broken heart syndrome. About 204 adults at high risk for complications will receive either cyclosporine or a placebo shortly after diagnosis. Researchers will…

This study is for adults with a type of brain tumor called oligodendroglioma. The goal is to see if a new combination of chemotherapy drugs (lomustine and temozolomide) can delay the need for radiation therapy, which can cause long-term side effects like memory and thinking probl…

This study tests a precise type of radiation called carbon ion re-radiotherapy for people whose head-and-neck cancer has returned or worsened after standard treatment. About 72 adults who cannot have surgery will receive this therapy to see if it causes fewer severe side effects …

This study tests whether a newer, more precise type of radiation (MR-guided adaptive radiotherapy) can treat liver tumors that have spread from other cancers with fewer side effects than standard radiation. About 90 adults with 1 to 3 small liver metastases will be enrolled. The …

This study tests how well PET/CT scans, along with other imaging, can define the exact edges of esophageal cancer before and after treatment. Researchers will compare these images to the actual tumor removed during surgery. The goal is to improve surgical planning and ensure all …

This study looks at why people with multiple myeloma fall and tests a home exercise program to prevent falls. About 60 adults on cancer therapy will use a training app for 24 weeks. The goal is to see if the program is easy to follow and reduces fear of falling.

This study tests whether proton beam radiation causes fewer side effects than standard photon radiation in people with glioblastoma, a serious brain cancer. About 326 adults who need radiation therapy will be randomly assigned to one of the two methods. The goal is to see if prot…

This study looks at men with prostate cancer who need radiation after their prostate is removed. It compares two types of radiation—proton therapy and standard photon therapy—to see which causes fewer bowel problems and improves quality of life. About 900 participants will be ran…

This study looks at whether using sedation instead of general anesthesia helps people having a specific type of stroke (vertebrobasilar) recover better after a procedure to remove a blood clot. About 128 adults with moderate to severe stroke symptoms will be enrolled. The goal is…

This study tests whether older adults (60+) with mild stroke or mini-stroke can be safely treated in a same-day outpatient clinic instead of being admitted to the hospital. Researchers will compare recovery, complications, and costs between the two approaches. If successful, this…

This study looks at whether taking probiotics (with or without vitamin B12) can improve the health of the mouth's bacteria and reduce gum disease in adults with severe periodontitis. Participants will receive standard gum treatment plus either a probiotic lozenge, a probiotic wit…

This study collects information from 10,000 adults who have had hip or knee replacement surgery at Heidelberg University Hospital. Researchers will follow participants during routine check-ups to see how long the artificial joints last, how well they function, and what problems m…

This study explores whether a special type of MRI can help doctors see and track lung damage in people with interstitial lung disease (ILD). Researchers will compare MRI images to standard CT scans and follow patients over time to see if the MRI can detect if the disease is getti…

This study is testing a simple blood test to monitor meningioma brain tumors after radiation therapy. Researchers will look at tiny particles in the blood to see if they can track tumor changes and predict outcomes without needing a surgical biopsy. The study involves 60 adults w…

This study looks at how gender shapes the way people with borderline personality disorder (BPD) experience relationships and see themselves. Researchers will interview 15 people of different genders with BPD and use special tests to measure hidden thoughts. The goal is to better …

This study is a registry that collects data from 200 adults with mediastinal lymphoma who receive proton radiotherapy. The goal is to track how well the treatment works and what side effects occur. Researchers will use this information to develop better planning guidelines for fu…