Unicancer

This study is testing whether adding a targeted chemotherapy infusion directly into the liver's blood supply improves the effectiveness of two immunotherapy drugs for advanced liver cancer. It will involve 196 adults in France with a high amount of liver tumor. The goal is to see…

This study is testing whether an existing cancer drug called zanidatamab can help treat several different types of advanced solid tumors that share a specific genetic alteration in the HER2 gene. The trial will enroll 105 adults with advanced endometrial, colorectal, head & neck,…

This study is testing if an immunotherapy drug called dostarlimab works better than standard chemotherapy as a first treatment for adults with certain rare, advanced cancers that have spread or cannot be surgically removed. About 120 participants will be randomly assigned to rece…

This large study is testing if a targeted pill called ribociclib can safely replace chemotherapy for certain patients with early-stage, hormone-sensitive breast cancer. It will enroll nearly 4,000 women who would typically be offered chemotherapy after surgery. The goal is to see…

This study is testing whether adding a digital health app to standard cancer care helps patients with advanced triple-negative breast cancer. About 472 patients starting their first treatment will either use the app to report symptoms and get advice or receive standard care alone…

This trial tests personalized immunotherapy treatments given before cancer surgery. It uses a rapid blood and tumor test called PORTRAIT to match each patient with the treatment most likely to work for their specific cancer. The goal is to shrink tumors, make surgery easier, and …

This study is testing a new approach for treating stage III melanoma that can be surgically removed. Researchers are injecting two immunotherapy drugs directly into the tumor before surgery, hoping this will be more effective and cause fewer body-wide side effects than standard I…

This study is testing a new strategy for monitoring people after treatment for HPV-positive throat cancer. It uses a simple blood test that looks for traces of HPV DNA to check if the cancer might be coming back. The goal is to see if this test can help doctors schedule fewer rou…

This study is for people with triple-negative breast cancer who still have cancer cells after initial chemo-immunotherapy and surgery. It tests if adding the pill capecitabine to the immunotherapy pembrolizumab after surgery is better at preventing the cancer from coming back tha…

This study is testing a different chemotherapy combination for people with advanced colorectal or stomach cancer who have a specific enzyme deficiency (DPD deficiency). This deficiency makes standard chemotherapy drugs too toxic. Researchers want to see if this new combination is…

This study is testing whether adding a new drug called ivonescimab to standard chemotherapy helps shrink tumors better in people with advanced stomach or esophageal cancer. It will enroll 88 adults whose cancer has spread or cannot be removed by surgery. The main goal is to see i…

This study is testing whether a new drug called ivonescimab works better than standard chemotherapy for people with advanced bile duct cancer whose first treatment has stopped working. It will involve 72 patients who previously took part in a related screening study. Participants…

This study is testing a combination of three drugs to treat a serious complication where HER2-positive breast cancer spreads to the fluid-filled lining around the brain and spinal cord. It aims to see if this approach can help patients live longer and improve their neurological s…

This study is testing a personalized treatment plan for early-stage triple-negative breast cancer. It aims to see if patients whose tumors have high levels of certain immune cells can safely avoid or receive less chemotherapy after surgery. The goal is to control the cancer while…

This study is testing an online program designed to help women at high risk for breast cancer lower their risk through lifestyle changes. The program includes a webinar and a personalized virtual visit to create a prevention plan. Researchers want to see if women find the program…

This study aims to collect real-world treatment and survival information from 400 patients with metastatic colorectal cancer that has a specific BRAF gene mutation. Researchers will gather medical records and biological samples during normal cancer care to better understand how t…

This study is testing whether an artificial intelligence (AI) tool can help patients and doctors make better decisions about breast cancer radiotherapy. The tool calculates a patient's personal risk of developing arm swelling (lymphedema) after treatment. Researchers will see if …

This international study aims to find better ways to predict which patients with advanced breast, lung, bladder, or stomach cancer will benefit from a newer type of targeted cancer drug called antibody-drug conjugates (ADCs). Researchers will collect blood and tumor samples from …