Unicancer

This study compares two drug combinations for people with advanced colorectal cancer that does not have a liver metastasis. Participants will receive either the standard treatment (FOLFIRI + bevacizumab) or an experimental combination (FOLFIRI + ivonescimab) every two weeks for u…

This study tests whether alternating two different targeted drugs (sacituzumab govitecan and trastuzumab deruxtecan) helps people with advanced HER2-low triple-negative breast cancer live longer compared to using just one drug alone. About 260 adults with metastatic or locally ad…

This study tests a new drug, prifetrastat, combined with fulvestrant for people with advanced HR+/HER2- breast cancer whose cancer has stopped responding to standard hormone therapy and CDK4/6 inhibitors. The goal is to see if this combination can control the cancer by targeting …

This study tests whether adding the drug Mitazalimab to standard chemotherapy helps people with advanced bile duct cancer live longer. About 160 adults whose cancer has spread or cannot be removed will receive either chemo alone or chemo plus Mitazalimab. Researchers will track s…

This study tests whether a simple blood test can identify people with advanced lung cancer who can be treated with immunotherapy alone, avoiding chemotherapy. About 275 participants with high PD-L1 levels and a low inflammation score (PTI=0) will receive a single immunotherapy dr…

This study tests whether giving chemotherapy directly into the liver artery (HAI) after surgery can delay cancer recurrence in people with colorectal cancer that spread to the liver. About 272 high-risk patients will receive either standard IV chemo or IV chemo plus HAI for at le…

This study tests whether a special scan (SPECT-CT) can show which side of the neck needs radiation in people with oropharyngeal cancer. Currently, both sides are treated to prevent hidden cancer spread, but this causes more side effects. The trial will include 128 patients and se…

This study looks at whether a genetic test (Prosigna®) can help decide if younger women with a common type of early breast cancer need chemotherapy. About 3380 premenopausal women will be randomly assigned to either standard treatment (always chemo plus hormone therapy) or a test…

This study aims to see if a simple blood test can find HPV-related throat and anal cancers early in men aged 50 and older. Participants will provide blood samples to check for signs of the virus and tumor DNA. If successful, this could lead to a national screening program to catc…

This study looks at whether easy-to-collect samples like blood, urine, stool, and vaginal swabs can help predict cancer in people with Lynch syndrome, a genetic condition that raises cancer risk. Currently, patients need invasive procedures like colonoscopies. The goal is to see …

This study looks at whether a simple blood test that detects tumor DNA can help doctors choose the right amount of chemotherapy for people with stage III colorectal cancer. About 2,450 participants will be split into groups based on their blood test results. Those with no detecta…

This study tests a new imaging method (antibody-based PET scan) to see if it can predict how well a targeted cancer drug (T-DXd) works in people with advanced breast cancer. The goal is to potentially replace tumor biopsies with a less invasive scan. About 30 participants already…

This study tests a new way to choose cancer treatments by quickly analyzing each patient's tumor and immune system using fresh samples. About 275 people with advanced solid tumors will have their treatment selected based on these detailed profiles, rather than just the cancer typ…