The University Of Hong Kong

This pilot study is testing whether a Bifidobacterium probiotic supplement can help lower blood pressure in 30 middle-aged Chinese adults with untreated hypertension. Participants will take the probiotic for 12 weeks, and researchers will monitor their blood pressure and other he…

This pilot trial is testing a digital health program called CHALAANE, which means 'walk' in Hindi and Urdu, for South Asian adults with knee osteoarthritis and obesity. The program combines a smartband, an AI-powered mobile app for tracking diet and activity, and a 12-week superv…

This trial tests whether a specific acupressure routine, performed by trained caregivers three times a week for a year, can slow cognitive decline in older adults with early or mild Alzheimer's disease. Participants will be randomly assigned to receive either the full acupressure…

This trial tests whether high-frequency repetitive transcranial magnetic stimulation (rTMS) can reduce cravings, drug use, and withdrawal symptoms in adults addicted to etomidate. Forty participants will receive either active rTMS or a sham (fake) treatment over 20 sessions in 4 …

This study tests a program called Snacktivity, which involves doing very short bursts of moderate exercise—like brisk walking for 2 to 5 minutes, several times a day—to see if it can improve thinking skills and the ability to manage daily health in people aged 60 and older with C…

This study tests whether a smart chatbot can help adults quit smoking as effectively as human support. About 1,000 smokers in Hong Kong will use a WhatsApp chatbot for 12 weeks, receiving personalized advice and encouragement. The goal is to see if the chatbot can boost quit rate…

This study tests whether swallowing capsules containing healthy donor stool can clear carbapenem-resistant Enterobacteriaceae (CRE) from the gut of hospitalized patients. CRE are superbugs that resist many antibiotics and can cause serious infections. The trial will compare the c…

This phase 2 trial tests whether adding asciminib to standard tyrosine kinase inhibitors can prevent relapse in patients with Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia or blastic phase chronic myeloid leukemia after a stem cell transplant. 45 participan…

This study tests whether taking folic acid (vitamin B9) daily for 90 days can lower the risk of death within one year for adults with acute kidney injury caused by infections. About 382 participants will either receive folic acid plus standard care or standard care alone. Researc…

This phase II trial tests whether giving pembrolizumab (an immunotherapy) plus chemotherapy before surgery, followed by maintenance pembrolizumab, can improve outcomes for people with locally recurrent nasopharyngeal carcinoma. About 53 participants will receive up to 6 cycles of…

This trial tests whether a finger-prick HbA1c test can detect type 2 diabetes better than the standard random blood glucose test in at-risk adults living in rural Dali, China. Researchers will compare detection rates and costs among 720 permanent rural residents with no known dia…

This study is testing whether a blood test that looks for genetic changes (ctDNA) can help detect lung cancer early in people who have suspicious lung nodules found on CT scans. Researchers will collect blood samples from 200 participants in Hong Kong and Vietnam at the start and…

This study will test whether low-dose CT scans can help find lung cancer early in high-risk smokers aged 50-79 in Hong Kong. About 15,000 participants will be randomly assigned to receive three rounds of CT scans or usual care. The main goal is to see if screening reduces lung ca…

This study tests whether a program of exercise, lifestyle changes, and a smart chatbot can prevent osteoporosis and sarcopenia in 8,336 adults aged 40-60. Participants are split into two groups: one gets active support with structured workouts and reminders, the other gets basic …

Researchers at the University of Hong Kong are studying whether the timing of weekly chatbot reminders changes how people engage with a digital smoking cessation service. About 350 Cantonese-speaking adults who used tobacco in the past 30 days will receive routine chatbot support…

Researchers in Hong Kong are testing whether a smartphone app with three Cantonese-speaking conversational companions can ease loneliness in adults aged 60 and older. Seventy-two participants who report at least moderate loneliness use the app for four weeks, then continue with a…

This study tests a 12-week program called EXCITE-PAC for family members caring for someone with dementia. The program combines counseling, group meetings, and phone support to help caregivers find more meaning and positivity in their role. Researchers will measure changes in care…

This trial tests whether Sleep Island, a WeChat mini-program for parents, can help preschool children sleep longer. Researchers will randomly assign 122 families to either use the app for 4 weeks or receive standard sleep education. The app tracks the child's sleep, gives persona…

This trial tests whether having family members write a digital diary during and after a loved one's ICU stay can help them cope with grief. Forty family members of ICU patients receiving life-sustaining treatment will be randomly assigned to either write a diary via WhatsApp or r…

This trial tests whether cognitive behavioural therapy for insomnia (CBT-I), with or without bright light therapy, can improve sleep and other outcomes in adolescents with ADHD who also have insomnia and a late sleep schedule. Participants aged 10-24 will receive CBT-I plus eithe…

This trial tests whether a mindfulness-centered AI chatbot can lower stress and boost mental health in Chinese men who have sex with men (MSM), a group that often faces minority stress and stigma. Participants will either use the chatbot for guided mindfulness exercises or read s…

This trial tests an 8-week eHealth program called eMindExCare that combines mindfulness practices with home-based aerobic and resistance exercises for prostate cancer patients undergoing active treatment. The study aims to see if the program is feasible and acceptable, and whethe…

This study tests whether a type of talking therapy called Cognitive Behavioral Therapy for Insomnia (CBTi) can improve sleep and reduce mental distress in young people aged 12-24 in Hong Kong who have moderate mental health concerns. Participants will attend six weekly group sess…

This pilot study tests whether a nurse-led digital cognitive behavioral therapy for insomnia (dCBT-I), delivered through a chatbot on WhatsApp, can help university students with mild to moderate anxiety or depression. Participants will complete a two-week daily sleep diary via th…

This study tests whether a combination of Chinese herbal medicines, multivitamins, and amino acid supplements can improve mood and sleep quality in adults aged 18 to 65 who have mild emotional or sleep disturbances. Participants take either the active supplements or a placebo for…

This pilot study tests a program to help construction workers in Hong Kong quit smoking. Participants will get nicotine gum, a week of nicotine replacement therapy samples, and 12 weeks of support from a chatbot via WhatsApp. The study will see if this combined approach is practi…

This study tests whether a special adhesive filled with strontium-doped bioactive glass-ceramic can reduce tooth sensitivity. 142 adults with sensitive teeth will receive a single application of either the new adhesive or a standard one. Pain levels will be checked right after an…

This study tests a 5-week digital breathing program (heart rate variability biofeedback) to see if it improves well-being in people with first episode psychosis. 80 participants will either do the breathing exercises or listen to music. The goal is to reduce symptoms like depress…

This study tests whether an AI-powered app can guide people with knee osteoarthritis through exercises at home, reducing pain and improving function as well as in-person physiotherapy. About 176 adults aged 50 and older with knee pain will be split into two groups: one receiving …

This pilot study tests a new program for young adults (25 or under) in Hong Kong who recently quit smoking. The program combines personalized counseling with an AI chatbot that sends supportive messages for 30 days. Researchers want to see if this approach is practical and accept…

This small pilot study will test whether an 8-week group mindfulness program can reduce stress, anxiety, depression, and insomnia in parents caring for children with autism or ADHD. Thirty Chinese caregivers will attend weekly sessions and complete surveys before and after the pr…

This pilot study tests whether a short, four-session cognitive behavioural therapy for insomnia (CBT-I) group, led by trained laypersons, can improve sleep quality in older adults in Hong Kong. Fifty participants aged 45 and older with mild depression and sleep problems will eith…

This study compares three sizes of small chest tubes (8, 12, and 14 French) for talc pleurodesis in patients with malignant pleural effusion—fluid buildup due to cancer. The goal is to see if the smallest tubes work as well as slightly larger ones, potentially reducing pain and c…

This study tests if acupuncture can lower pain and the need for painkillers after hemorrhoid removal. About 100 adults having surgery for severe hemorrhoids will get either real acupuncture or a sham version over 5 days. Researchers will track pain levels, medication use, and rec…

This study tests whether chewing xylitol gum for 4 weeks, along with text reminders, helps daily smokers cut down or quit. About 134 Hong Kong adults who smoke at least one cigarette daily will be split into two groups: one gets the gum and support, the other gets brief advice on…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve movement and balance in children with cerebellar ataxia, a condition that causes coordination problems. Twenty children aged 4 to 18 will receive either real or sham (fake) rTMS to see if …

Researchers at the University of Hong Kong are testing whether a generative AI patient simulation platform helps third-year nursing students feel more prepared and competent before their first acute clinical practicum. The trial enrolls 44 undergraduate nursing students who are r…

This study checks whether an Apple Watch Series 9 can accurately measure key health indicators—like oxygen levels and exercise capacity—in adults with heart conditions such as congenital heart disease, heart failure, or coronary artery disease. Participants wear the smartwatch du…

This study aims to create a risk index for postpartum depression by analyzing sleep patterns in 60 Hong Kong mothers. Participants will wear an actigraphy watch for 14 days to track sleep quality and efficiency, while also completing questionnaires about mood and anxiety. The goa…

This study aims to find early signs of diseases like heart disease, diabetes, and cancer by analyzing blood samples over time. Researchers will collect health data and blood from 15,000 adults aged 40-70 to create personalized health baselines using artificial intelligence. The g…

This study tests whether a combination of a 90-minute home visit by trained student interns and a month of daily AI-generated health messages can encourage older adults in Hong Kong to join District Health Centres. 180 adults aged 65 and older who are not yet members will be rand…

This study aims to see if a urine test for HPV is acceptable and effective for cervical cancer screening in the community. About 8,620 women aged 26-65 will provide a urine sample at home or a clinic. If the urine HPV test is positive, a follow-up DNA test will help decide who ne…

This study tests whether a nurse-led discharge program helps patients become more active in managing their own health after leaving the hospital. About 120 adults in Hong Kong who are stable enough to go home will take part. Researchers will measure changes in patient activation …

This study tests a program called ChatACP that sends daily messages and uses a chatbot to help family members of nursing home residents prepare for advance care planning—discussions about future medical and personal care. About 60 family members will use the program for 10 days a…

This study will test if a camouflaged WeChat mini-program is a feasible and acceptable way to support Chinese immigrant women in Hong Kong who have experienced intimate partner violence. About 86 women aged 18 to 45 will use the program and provide feedback. The goal is to see if…

This study will take small kidney tissue samples from 42 liver transplant patients who have hepatorenal syndrome (HRS), a condition where the kidneys stop working properly due to severe liver disease. Researchers want to see if the kidneys are actually damaged or just temporarily…