The Affiliated Nanjing Drum Tower Hospital Of Nanjing University Medical School

This 76-week study tests whether mazdutide, a weekly injection already used for diabetes, can slow memory and thinking decline in 420 adults aged 50-75 with type 2 diabetes and early dementia. Half receive the drug, half a placebo. Researchers will measure changes in thinking ski…

This study tests whether metformin, a standard diabetes medicine, can improve heart function in people who have received a mechanical heart pump (LVAD) for severe heart failure. Researchers will give metformin or a placebo to 108 patients for 12 months and check heart function, b…

This phase 2 trial tests a combination of liposomal irinotecan, fluorouracil, leucovorin, and sintilimab, followed by radiation therapy, as a first-line treatment for people with locally advanced biliary tract cancer that cannot be removed with surgery. About 31 participants will…

This phase 3 trial tests whether the anti-inflammatory drug ketorolac can improve outcomes in 360 people undergoing emergency surgery for a life-threatening aortic dissection. Participants receive either ketorolac or a placebo before and after surgery, alongside standard care. Re…

This trial tests whether electro-acupuncture, a treatment that uses fine needles with a mild electric current, can improve memory and thinking in people aged 55 to 79 who have subjective cognitive decline, a condition where people notice memory problems but standard tests still l…

This pilot study tests whether a gentle electrical stimulation of the ear (taVNS) can help overweight or obese people lose more weight when they haven't lost enough on the medication tirzepatide alone. 24 participants will receive either active ear stimulation or a sham (fake) st…

This trial tests whether an artificial intelligence system can help optimize insulin pump settings remotely for people with type 1 diabetes. The AI analyzes continuous glucose monitor and pump data to suggest personalized adjustments, which a doctor then reviews before sending to…

This trial tests whether the drug rezvilutamide, taken alone for 48 weeks after prostate removal surgery, can prevent cancer from coming back in men at high risk of recurrence. Standard treatment often includes long-term hormone therapy with significant side effects. The study ai…

This early-stage study tests a new treatment called CHT101 for people with severe lupus that hasn't improved with standard treatments. CHT101 uses specially engineered immune cells (CAR-T cells) to target and destroy certain immune cells that drive lupus. The study will enroll 15…

This pilot study tests a device that gently stimulates a nerve in the ear (taVNS) to help overweight or obese people who didn't lose much weight after 12 weeks of diet and exercise. 24 participants will get either real or sham stimulation twice daily for 12 more weeks, while cont…

This study tests whether giving a stronger antibiotic (piperacillin-tazobactam) before liver surgery can prevent surgical site infections better than the standard antibiotic (cefuroxime) in hospitals with high antibiotic resistance. About 378 adults having planned liver surgery w…

This study tests a new nanovaccine made from engineered bacteria that targets KRAS mutations in colorectal and pancreatic cancer patients who have had surgery and chemotherapy but are at high risk of their cancer coming back. The vaccine is designed to train the immune system to …

This study tests whether using a robot to help remove large blood clots in the brain (from a hemorrhagic stroke) leads to better recovery than standard surgery. About 198 adults with a large basal ganglia hemorrhage will be randomly assigned to robot-assisted or traditional surge…

This study is tracking 3000 adults with type 2 diabetes who are starting a new combination pill called Proline Plus Empagliflozin. Researchers want to see how well it controls blood sugar and if it is safe when used in everyday medical practice. The study does not change how doct…

This study is for people with advanced pancreatic cancer that has spread and is no longer helped by first-line chemotherapy. It tests a mix of drugs (nal-IRI, 5-FU, leucovorin, benmelstobart, and anlotinib) with or without focused radiation (SBRT). The goal is to see if this comb…

This study tests a drug called efsubaglutide alfa to help people who are still obese six months after weight-loss surgery lose more weight. About 60 adults aged 18 to 55 with a BMI of 28 or higher will take the drug or a placebo. The main goal is to see how much weight they lose …

This study tests whether the anti-inflammatory drug colchicine can reduce organ damage after heart surgery. About 768 adults aged 50-80 having planned heart surgery will take either colchicine or a placebo before and after their operation. Researchers will track complications lik…

This early-phase study tests whether a woman's own natural killer cells, processed in a lab and infused into her uterus, can improve uterine immune function and lead to successful pregnancy. It includes 14 women with a history of recurrent miscarriage, failed IVF, unexplained inf…

This early study tests whether cells from a woman's own belly fat can help thicken the uterine lining in those with infertility due to a thin lining or uterine scars. Ten women who have not responded to other treatments will receive an infusion of these cells into the uterus. The…

This study tests whether combining the immunotherapy drug tislelizumab with chemotherapy (paclitaxel, cisplatin, 5-FU) can shrink advanced head and neck tumors before surgery or chemoradiation. About 29 adults with stage III-IVb cancer will receive the combo for three cycles. Res…

This trial tests whether taking biopsy samples from only the side of the prostate where an MRI shows a suspicious lesion can match the standard approach of sampling both sides. Men with suspected prostate cancer and a single MRI lesion will be randomly assigned to receive either …

This study is testing a new, non-invasive liver scan called iLivTouch to see if it can accurately detect a serious liver condition called MASH in people who have both type 2 diabetes and fatty liver disease. The scan measures liver inflammation, fat, and stiffness without any nee…

This pilot study is testing whether a virtual reality (VR) cognitive training program can help protect memory and thinking skills in adults aged 45-80 with type 2 diabetes and mild cognitive impairment. Forty participants will be randomly assigned to either 16 weeks of VR-based t…

This study is testing whether a drug called aniracetamfen can safely reduce pain and help people recover faster after a major pancreatic surgery called pancreaticoduodenectomy. About 35 adults who are having this surgery will receive the drug, and researchers will track their pai…

This study tests two intravenous painkillers—acetaminophen and hydromorphone—in 30 adults with sudden, severe chest pain. Researchers will measure pain relief within 30 minutes and track safety. The goal is to find better ways to manage acute chest pain in the emergency room.

This study will use artificial intelligence to create a risk prediction model for head and neck cancers, including cancers of the throat and voice box. Researchers will collect data from 3000 participants, including their medical history, lifestyle habits, and laryngoscopy images…

This study is observing 1,000 people with liver cirrhosis who have bacterial infections and are being treated with β-lactam antibiotics. Researchers want to see how the body processes these drugs and whether personalized dosing could improve survival. The study is observational, …

This study is testing a risk prediction model for MDRGNB, a type of drug-resistant infection, in 1,000 ICU patients across multiple hospitals. Researchers will check how well the model predicts who gets infected, using data collected within 48 hours of ICU admission. The goal is …

This study looks at tiny particles called exosomes in the blood of 300 people who experienced sudden cardiac death after a heart attack. Researchers want to see if certain molecules in these particles can help predict who is at highest risk. The goal is to improve early warning a…

This study looks at how the brain reacts to different nutrients (sugar, fat, or protein) in people with obesity compared to healthy-weight individuals. Researchers will use brain scans and blood tests to see if there are differences in brain activity and metabolism after eating. …

This study follows 300 adults with end-stage heart failure who receive a left ventricular assist device (LVAD) as part of their routine care. Researchers will track survival, complications, and hospital readmissions over 3-5 years, and analyze heart tissue and blood samples to fi…