The Affiliated Nanjing Drum Tower Hospital Of Nanjing University Medical School

This study tests whether colchicine, an anti-inflammatory drug, can prevent organ damage caused by inflammation after heart surgery. About 768 adults aged 50-80 having planned heart surgery will receive colchicine or a placebo. Researchers will monitor for complications like new …

This study tests a new treatment for people with advanced pancreatic cancer that has spread and stopped responding to initial chemotherapy. The treatment combines chemotherapy (nal-IRI/5-FU/LV) with an immunotherapy (PD-L1 inhibitor) and a targeted anti-angiogenic drug, with or w…

This early-phase study tests whether a woman's own modified immune cells (called NK cells) can improve fertility and pregnancy outcomes. It includes 14 women with a history of miscarriage, failed IVF, or pregnancy complications linked to abnormal uterine NK cells. The treatment i…

This study tests a new vaccine made from engineered bacteria that targets KRAS mutations in colorectal and pancreatic cancer. It is given after surgery and chemotherapy to patients at high risk of recurrence. The goal is to see if the vaccine is safe and can help prevent the canc…

This study tests whether the anti-inflammatory painkiller ketorolac can improve outcomes for 360 people undergoing emergency surgery for a severe tear in the main artery from the heart (Stanford Type A aortic dissection). Participants receive either ketorolac or a placebo before …

This study tests a drug called efsubaglutide alfa to help people who remain obese six months after weight-loss surgery. About 60 adults aged 18-55 with a BMI of 28 or higher will receive either the drug or a placebo. The main goal is to see how much weight they lose and if the dr…

This study compares robot-assisted, minimally invasive surgery to traditional open surgery for removing large blood clots in the brain caused by hemorrhagic stroke. About 198 adults with a large basal ganglia bleed will be randomly assigned to one of the two approaches. The goal …

This study looks at how well a new diabetes pill (Proline Plus Empagliflozin) works in everyday medical practice. About 3,000 adults with type 2 diabetes will take the pill, either alone or with other medicines, and doctors will check their blood sugar control after 24 weeks. The…

This study tests whether a drug called tislelizumab, combined with chemotherapy (APF), followed by surgery or radiation, can shrink or control advanced head and neck tumors. About 29 adults with stage III-IVb cancer will receive this treatment. The goal is to see if the tumors di…

This early-phase study tests a new treatment called CHT101 for people with lupus that has not responded to standard therapies. CHT101 uses specially engineered immune cells (CAR-T cells) to target and attack faulty immune cells driving the disease. The study will enroll 15 partic…

This study tests whether a special cell mixture from a woman's own fat can help thicken the uterine lining in those with infertility due to a thin lining or scarring. Ten participants will receive the treatment and be monitored for improvements in lining thickness and menstrual f…

This study tests a weekly injection called mazdutide in 420 people with type 2 diabetes who also have mild memory problems or early dementia. The goal is to see if the drug can slow down or improve thinking and memory decline over 76 weeks. Participants are randomly assigned to r…

This study looks at two intravenous pain medicines—acetaminophen and hydromorphone—to see which works better and is safer for adults with sudden, severe chest pain. About 30 people aged 18 to 64 will take part. The goal is to find the best way to ease pain quickly and help patien…

This study is testing whether a drug called aniracetamfen can safely reduce pain and help people recover faster after a major pancreatic surgery called pancreaticoduodenectomy. About 35 adults who are having this surgery will receive the drug, and researchers will track their pai…

This study looks at tiny particles called exosomes in the blood of people who have had a sudden cardiac arrest. Researchers want to see if certain molecules in these particles can help predict who is at risk. The goal is to find better ways to identify high-risk patients early an…

This study looks at how the brain and body react to different nutrients (sugar, fat, protein) in people with obesity compared to healthy-weight individuals. Sixty participants will drink a liquid meal and have brain scans and blood tests to measure changes. The goal is to underst…

This study follows 300 adults with end-stage heart failure who receive a left ventricular assist device (LVAD) as part of their standard care. Researchers will track survival, complications, and hospital readmissions for up to 5 years. They will also analyze heart tissue and bloo…