State University Of New York At Buffalo

This study tests whether eating low-protein meals (10% protein instead of the usual 20%) can boost the immune system's response to immunotherapy in cancer patients. Researchers will enroll 30 adults with solid tumors that have spread. The main goal is to see if patients can stick…

This study tests a program called CVD-FIT for African American adults who struggle to afford food and are at risk for heart disease. Participants get monthly income support, weekly incentives to buy healthy food, and phone-based education on heart health. The goal is to see if th…

This study tests whether adding bicalutamide to sunitinib can safely control advanced kidney cancer that has stopped responding to standard targeted therapy. About 28 adults with this type of cancer will receive the combination. The goal is to see if the treatment shrinks tumors …

This study tests whether metformin, a common diabetes medicine, is safe and can protect the brain in people aged 55 to 75 with multiple sclerosis (MS). Participants will take metformin or a placebo for 9 months, either alone or with their usual MS treatment. The goal is to see if…

This study tests whether school-based health centers can improve asthma care for children in underserved communities. About 400 children with uncontrolled asthma will receive guideline-based checkups, daily preventive medication at school, and self-management support. The goal is…

This study checks how well a new device called TonoVera measures eye pressure compared to standard tools. It involves 300 adults with glaucoma. The goal is to see if the new device is accurate and easier to use.

This study tests whether a brief, friend-focused motivational interview can reduce the risk of alcohol-involved sexual assault. About 560 women who drink heavily and socialize together at least once a week will take part. Researchers will track changes in drinking habits and read…

This study tests whether adding continuous glucose monitoring (CGM) to the standard Diabetes Prevention Program (DPP) helps adults with prediabetes stick with healthy habits and lower their risk of developing type 2 diabetes. About 214 adults with prediabetes will receive DPP coa…

This study tests whether starting personalized aerobic exercise soon after a concussion helps active-duty military members recover faster and avoid long-term symptoms. About 168 participants will either do daily exercise plus standard care or standard care alone. The goal is to s…

This pilot study is testing whether intermittent fasting (with an optional plant-rich diet) is practical and helpful for 30 men with prostate cancer who are receiving hormone therapy (androgen deprivation therapy). The main goal is to see if patients can stick with the diet, not …

This pilot study is testing whether intermittent fasting (calorie restriction on alternate days) combined with a plant-based protein diet can help cancer patients respond better to chemotherapy. The study will enroll 30 adults with various cancers who are scheduled for chemothera…

This study tests whether toothbrushes with tapered bristles are better at removing plaque and reducing gum bleeding than regular round bristles, without causing scratches. About 70 adults with gum disease will use one of two toothbrushes at home for 4 weeks. Researchers will chec…

This study is testing whether a non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) can improve movement and thinking problems in children aged 10-15 who have had a mild traumatic brain injury (concussion). The researchers will use brain…

This study tests two different programs to help pregnant women stop using both cigarettes and e-cigarettes. Researchers will enroll 45 low-income mothers early in pregnancy and compare quitting rates between those who quit both at once, those who quit step-by-step, and those who …

This study tests a 24-week community program for adults aged 60 and older. Participants will take part in group art activities and dual-task exercise games at local YMCAs. The goal is to see if these fun, social activities can improve thinking skills and physical function. The st…

This study tests whether sniffing isopropyl alcohol (rubbing alcohol) can reduce nausea in children visiting the emergency room. About 84 kids aged 7 and older with nausea will be randomly assigned to inhale alcohol, take standard anti-nausea medicine, or receive a placebo. The g…

This study looks at whether giving the right amount of portable oxygen during exercise helps people with chronic lung diseases like ILD and COPD be more active and feel better in daily life. Researchers will compare two types of oxygen devices and no oxygen at all, each used for …

This study looks at whether a numbing shot (hematoma block) with either a tiny dose of ketamine or a nasal spray (fentanyl) can control pain as well as full sedation in children aged 3 to 17 who need a wrist fracture realigned. About 50 kids will be randomly assigned to one of th…

This study tests whether a 16-week hydration program can reduce side effects like nausea and dehydration in people starting GLP-1 medications (such as Ozempic or Wegovy). Researchers will track 30 adults aged 18-60 who recently started the drug, measuring hydration levels and sid…

This study tests whether vagus nerve stimulation (VNS) paired with rehabilitation can improve leg and walking function in people who have had an ischemic stroke. Researchers will enroll 24 adults who are already approved for VNS therapy for arm problems. The goal is to see if thi…

This study tests whether a noninvasive brain stimulation method, combined with hand exercises, can improve grasping ability in people with chronic spinal cord injury. About 54 adults with neck-level injuries will receive either real or sham stimulation during training sessions. T…

This study tests a brief, 4-session cognitive behavioral treatment (CBT) for people with urological chronic pelvic pain syndrome (UCPPS), including interstitial cystitis and chronic prostatitis. The goal is to reduce pain and improve quality of life. Researchers will enroll 240 a…

This pilot study explores whether it's possible to measure and improve sleep and body clock rhythms in critically ill children aged 3 to 6 in the pediatric ICU. Researchers will use a wrist monitor and saliva tests to track sleep, and try two simple interventions: bright light th…

This observational study follows 250 children from BIPOC and low-income families who are overweight or obese. Researchers will measure their food preferences, physical activity, and decision-making every year for three years to see how these factors relate to changes in body weig…

This study looks at how people with Parkinson's disease learn to understand speech and how that relates to their own speaking ability. Researchers will have 50 participants complete listening and speaking tasks to measure speech intensity, rate, and clarity. The goal is to find l…

This study explores why older adults often have weaker responses to the pneumococcal vaccine, which protects against pneumonia. Researchers will compare immune cells called neutrophils in 60 healthy young (21-40) and older (65+) adults before and after vaccination. The goal is to…

This study looks at how daily vapers and cigarette smokers feel when they stop using nicotine for 24 hours. Researchers will measure withdrawal symptoms like mood changes, cravings, and attention problems in 370 participants. The goal is to understand nicotine dependence better a…

This study looks at how people with schizophrenia experience nicotine withdrawal when they stop vaping or smoking for 24 hours. Researchers will compare withdrawal symptoms, mood, and thinking skills between daily vapers and daily smokers. The goal is to understand nicotine depen…

This study follows 450 cancer patients receiving immunotherapy to see how cannabis use affects their symptoms like pain, sleep, anxiety, and quality of life. Participants complete surveys and daily assessments over a year. The goal is to understand the benefits and risks of canna…

This study looks at whether patients in the ICU who need a tracheostomy can keep getting nutrition through a tube right up until surgery, instead of stopping 6 hours before. The goal is to see if this helps them get more food without increasing the risk of food getting into the l…

This study follows 600 black and white adults with solid tumor cancer who use cannabis at least weekly or not at all. Participants report pain, symptoms, and cannabis use through a smartphone app and surveys for one year. The goal is to understand how cannabis affects pain and op…

This study looks at how diet affects blood sugar control in 40 emergency medical workers who work night shifts. Participants will try a dietary program to see if it helps and if they can stick with it. The goal is to learn more about supporting the health of those who work overni…

This study tests whether a program called Military PAIRS, where Navy members work in pairs to support each other, can reduce sexual violence and risky drinking. About 132 active-duty U.S. Navy members who drink heavily will take part. They will answer questions about their experi…

This study aims to find the best work/rest schedule for soldiers in hot weather, so they can finish missions faster without overheating or getting too tired. Researchers will measure body temperature, strength, and heart rate in 24 healthy, active adults during exercise in the he…

This study looks at whether community pharmacies in under-resourced areas can help people find resources for social needs like food, housing, and transportation. About 1,600 adults will take part. The goal is to see if this help reduces hospital stays and emergency room visits ov…

This study looks at whether a teacher-led program called the Early Childhood Friendship Project can help preschoolers be less aggressive and more kind. About 600 children from diverse backgrounds will take part. Researchers will measure changes in behavior, thinking skills, and e…

This study tests a new imaging device that uses light and sound to check blood flow in foot wounds. The goal is to see if this tool can help doctors decide on better treatments. About 25 people with chronic foot ulcers will take part. This is a small early study to see if the ide…