St. Joseph's Healthcare Hamilton

This study tests whether a sedative called dexmedetomidine can help critically ill patients tolerate non-invasive ventilation (a mask that helps breathing) and avoid needing a breathing tube. About 846 adults with acute respiratory failure will receive either the drug or a placeb…

This study tests whether a dye called indocyanine green (ICG) can help surgeons see the exact boundary of a lung cancer tumor during robotic surgery. The dye makes the healthy lung glow, leaving the cancerous segment dark. The surgeon then removes only that dark segment, sparing …

This study tests two digital treatment programs for people recently released from prison who have a history of substance use problems. The goal is to see if these programs are practical and helpful in preventing relapse and return to prison. About 20 participants will use the dig…

This study tests whether Multiprofen-CC cream, applied three times daily, reduces pain in adults with hand osteoarthritis. Forty-two participants will use both the active cream and a placebo for two weeks each, in random order. Researchers will measure pain, hand function, and si…

This study tests a 4-week mindfulness program designed specifically for new mothers and birthing parents with anxiety disorders. Researchers will use surveys and brain scans to see if the program helps reduce anxiety, improve emotion regulation, and increase body awareness. The t…

This study tests a new psychological therapy designed for people whose depression is linked to difficult childhood experiences. The therapy aims to improve mood, emotional control, and distressing thoughts. Researchers will also look at biological changes in the blood. The trial …

This study tests a new way to remove small lung tumors using a 3D computer model and a dye that makes the tumor glow during surgery. The goal is to help surgeons remove only the diseased part of the lung, avoiding a full lobe removal. About 32 adults with early-stage lung cancer …

This study is testing whether DNA from blood, sputum, lung fluid, and breath can be used to find genetic changes in non-small cell lung cancer. Researchers will collect samples from 210 patients before and after surgery, then follow them for 24 months to see if these tests can de…

This study creates a large, standardized platform to collect data from 900 people with mood disorders like depression and bipolar disorder. Researchers will gather clinical tests, blood samples, and brain scans to find biomarkers that can help match the right treatment to each pe…

This study explores whether a non-invasive brain stimulation technique called deep transcranial magnetic stimulation (dTMS) is safe and tolerable for older adults with mild memory or thinking problems. Thirty participants aged 60-90 will receive one of three types of dTMS coils. …

This study looks at whether certain common medications, known as QT-prolonging drugs, actually cause serious heart problems in hospitalized adults. Researchers will analyze data from over 990,000 patients to compare those who had heart events with those who did not. The goal is t…

This study looks at whether teaching college women who diet about how the body naturally controls weight can change their beliefs about weight control and improve body image and self-esteem. About 150 undergraduate dieters will take part in one of three education programs. The go…